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ARG2 arginase 2 [ Homo sapiens (human) ]

Gene ID: 384, updated on 12-Oct-2019

Summary

Official Symbol
ARG2provided by HGNC
Official Full Name
arginase 2provided by HGNC
Primary source
HGNC:HGNC:664
See related
Ensembl:ENSG00000081181 MIM:107830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thyroid (RPKM 94.3), prostate (RPKM 64.4) and 23 other tissues See more
Orthologs

Genomic context

See ARG2 in Genome Data Viewer
Location:
14q24.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (67619920..67651708)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (68086579..68118437)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene gephyrin Neighboring gene uncharacterized LOC105370543 Neighboring gene protein kinase C eta pseudogene Neighboring gene high mobility group box 1 pseudogene 34 Neighboring gene RNA, 5S ribosomal pseudogene 386 Neighboring gene cytochrome c oxidase subunit 7A2 pseudogene 1 Neighboring gene vesicle transport through interaction with t-SNAREs 1B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr downregulates the expression of ARG2 in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arginase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arginase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
arginine catabolic process to ornithine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of CD4-positive, alpha-beta T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of chemokine (C-C motif) ligand 4 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of chemokine (C-C motif) ligand 5 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-13 secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-17 secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of macrophage inflammatory protein 1 alpha production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tumor necrosis factor secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of type 2 immune response IEA
Inferred from Electronic Annotation
more info
 
nitric oxide biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cellular senescence IDA
Inferred from Direct Assay
more info
PubMed 
regulation of interleukin-1 beta secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of reactive oxygen species biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
striated muscle contraction IEA
Inferred from Electronic Annotation
more info
 
urea cycle IEA
Inferred from Electronic Annotation
more info
 
urea cycle TAS
Traceable Author Statement
more info
 
ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
arginase-2, mitochondrial
Names
L-arginine amidinohydrolase
L-arginine ureahydrolase
arginase II
arginase, type II
kidney arginase
kidney-type arginase
non-hepatic arginase
nonhepatic arginase
type II arginase
NP_001163.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011964.1 RefSeqGene

    Range
    5059..36847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001172.4NP_001163.1  arginase-2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001163.1

    Status: REVIEWED

    Source sequence(s)
    AL135439, BC029050
    Consensus CDS
    CCDS9785.1
    UniProtKB/Swiss-Prot
    P78540
    UniProtKB/TrEMBL
    A0A024R6A0
    Related
    ENSP00000261783.3, ENST00000261783.4
    Conserved Domains (1) summary
    cd09989
    Location:26321
    Arginase; Arginase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    67619920..67651708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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