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Arg2 arginase type II [ Mus musculus (house mouse) ]

Gene ID: 11847, updated on 17-Jan-2023

Summary

Official Symbol
Arg2provided by MGI
Official Full Name
arginase type IIprovided by MGI
Primary source
MGI:MGI:1330806
See related
Ensembl:ENSMUSG00000021125 AllianceGenome:MGI:1330806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AII
Summary
Predicted to enable arginase activity; manganese ion binding activity; and nitric-oxide synthase binding activity. Involved in several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process; and negative regulation of cytokine production. Acts upstream of or within striated muscle contraction and ureteric bud development. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ARG2 (arginase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 66.9), small intestine adult (RPKM 62.2) and 8 other tissues See more
Orthologs
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Genomic context

See Arg2 in Genome Data Viewer
Location:
12; 12 C3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (79177562..79203075)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (79130788..79156301)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9230116L04 gene Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class H Neighboring gene ribosomal protein large PO subunit pseudogene Neighboring gene predicted gene, 40462 Neighboring gene vesicle transport through interaction with t-SNAREs 1B Neighboring gene retinol dehydrogenase 11 Neighboring gene retinol dehydrogenase 12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arginase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables arginase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in arginine catabolic process to ornithine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in arginine catabolic process to ornithine ISO
Inferred from Sequence Orthology
more info
 
involved_in arginine metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of chemokine (C-C motif) ligand 4 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of chemokine (C-C motif) ligand 5 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-13 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of macrophage inflammatory protein 1 alpha production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of striated muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type 2 immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of L-arginine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within striated muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within urea cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in ureteric bud development IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
arginase-2, mitochondrial
Names
arginase II
kidney-type arginase
non-hepatic arginase
type II arginase
NP_033835.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009705.3NP_033835.1  arginase-2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_033835.1

    Status: VALIDATED

    Source sequence(s)
    AC154585, AF032466, DV039756
    Consensus CDS
    CCDS26007.1
    UniProtKB/Swiss-Prot
    O08691
    UniProtKB/TrEMBL
    A0A8C6H8U6
    Related
    ENSMUSP00000021550.7, ENSMUST00000021550.7
    Conserved Domains (1) summary
    cd09989
    Location:26321
    Arginase; Arginase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    79177562..79203075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)