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KIF22 kinesin family member 22 [ Homo sapiens (human) ]

Gene ID: 3835, updated on 6-Jan-2019

Summary

Official Symbol
KIF22provided by HGNC
Official Full Name
kinesin family member 22provided by HGNC
Primary source
HGNC:HGNC:6391
See related
Ensembl:ENSG00000079616 MIM:603213
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KID; OBP; KNSL4; OBP-1; OBP-2; SEMDJL2; A-328A3.2
Summary
The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Broad expression in bone marrow (RPKM 24.9), testis (RPKM 13.3) and 24 other tissues See more
Orthologs

Genomic context

See KIF22 in Genome Data Viewer
Location:
16p11.2
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (29790713..29805543)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29801383..29816706)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene zymogen granule protein 16 Neighboring gene uncharacterized LOC105371167 Neighboring gene uncharacterized LOC107984837 Neighboring gene uncharacterized LOC112268170 Neighboring gene MYC associated zinc finger protein Neighboring gene proline rich transmembrane protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Spondyloepimetaphyseal dysplasia with multiple dislocations
MedGen: C1863732 OMIM: 603546 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Seventy-five genetic loci influencing the human red blood cell.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev KID is hypothesized to be a human breast cancer variant of Rev/Rex effector binding protein (REBP), a nuclear protein that binds HIV-1 Rev, co-localizes with Rev in the nucleoplasm and nuclear periphery of cells, and enhances Rev-dependent mRNA expression PubMed
Vpr vpr HIV-1 Vpr upregulates KIF22 in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Kinesins, organism-specific biosystem (from REACTOME)
    Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
  • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
    MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based movement TAS
Traceable Author Statement
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
mitotic metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromatin IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinetochore TAS
Traceable Author Statement
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF22
Names
kinesin-like DNA-binding protein pseudogene
kinesin-like protein 4
oriP binding protein
origin of plasmid DNA replication-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032055.1 RefSeqGene

    Range
    5001..19673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256269.1NP_001243198.1  kinesin-like protein KIF22 isoform 2

    See identical proteins and their annotated locations for NP_001243198.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus than isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK223431, AK316389, BC028155, DC370294
    Consensus CDS
    CCDS58444.1
    UniProtKB/Swiss-Prot
    Q14807
    UniProtKB/TrEMBL
    A0A024R632
    Conserved Domains (3) summary
    smart00129
    Location:2307
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01376
    Location:1298
    KISc_KID_like; Kinesin motor domain, KIF22/Kid-like subgroup
    pfam12836
    Location:528578
    HHH_3; Helix-hairpin-helix motif
  2. NM_001256270.1NP_001243199.1  kinesin-like protein KIF22 isoform 2

    See identical proteins and their annotated locations for NP_001243199.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus than isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC009133, AK223431, AK316050, BC004352, BC028155
    Consensus CDS
    CCDS58444.1
    UniProtKB/Swiss-Prot
    Q14807
    UniProtKB/TrEMBL
    A0A024R632, B7Z9T5
    Related
    ENSP00000454957.1, ENST00000561482.5
    Conserved Domains (3) summary
    smart00129
    Location:2307
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01376
    Location:1298
    KISc_KID_like; Kinesin motor domain, KIF22/Kid-like subgroup
    pfam12836
    Location:528578
    HHH_3; Helix-hairpin-helix motif
  3. NM_007317.2NP_015556.1  kinesin-like protein KIF22 isoform 1

    See identical proteins and their annotated locations for NP_015556.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK223431, BC028155, DC370294
    Consensus CDS
    CCDS10653.1
    UniProtKB/Swiss-Prot
    Q14807
    Related
    ENSP00000160827.4, ENST00000160827.8
    Conserved Domains (2) summary
    cd01376
    Location:43366
    KISc_KID_like; Kinesin motor domain, KIF22/Kid-like subgroup
    cl28530
    Location:596646
    ComEA; DNA uptake protein ComE and related DNA-binding proteins [Replication, recombination and repair]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    29790713..29805543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450270.1XP_024306038.1  kinesin-like protein KIF22 isoform X1

    Conserved Domains (2) summary
    cd01376
    Location:43366
    KISc_KID_like; Kinesin motor domain, KIF22/Kid-like subgroup
    cl28530
    Location:596632
    ComEA; DNA uptake protein ComE and related DNA-binding proteins [Replication, recombination and repair]

RNA

  1. XR_243280.4 RNA Sequence

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