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KLRC2 killer cell lectin like receptor C2 [ Homo sapiens (human) ]

Gene ID: 3822, updated on 9-Dec-2024

Summary

Official Symbol
KLRC2provided by HGNC
Official Full Name
killer cell lectin like receptor C2provided by HGNC
Primary source
HGNC:HGNC:6375
See related
Ensembl:ENSG00000205809 MIM:602891; AllianceGenome:HGNC:6375
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKG2C; CD159c; NKG2-C
Summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 6.7), spleen (RPKM 3.4) and 9 other tissues See more
Orthologs
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Genomic context

See KLRC2 in Genome Data Viewer
Location:
12p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10430599..10436010, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10583198..10588609, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene KLRC4-KLRK1 readthrough Neighboring gene killer cell lectin like receptor C4 Neighboring gene killer cell lectin like receptor C3 Neighboring gene killer cell lectin like receptor C1 Neighboring gene uncharacterized LOC105369657 Neighboring gene eukaryotic translation initiation factor 2 subunit gamma B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of killer cell lectin-like receptor subfamily C, member 2 (KLRC2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: KLRC3

Clone Names

  • MGC138244

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MHC class I protein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables activating MHC class Ib receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables protein antigen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
NKG2-C type II integral membrane protein
Names
CD159 antigen-like family member C
NK cell receptor C
NKG2-C-activating NK receptor
killer cell lectin-like receptor subfamily C, member 2
natural killer cell receptor G2-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002260.4NP_002251.2  NKG2-C type II integral membrane protein

    See identical proteins and their annotated locations for NP_002251.2

    Status: REVIEWED

    Source sequence(s)
    AC068775, AF260134, BC093644, X54869
    Consensus CDS
    CCDS31745.1
    UniProtKB/Swiss-Prot
    O43802, P26717, Q52M74, Q9NR42
    UniProtKB/TrEMBL
    A0A897PVC2
    Related
    ENSP00000371327.2, ENST00000381902.7
    Conserved Domains (1) summary
    cd03593
    Location:117229
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    10430599..10436010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)