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KLRC3 killer cell lectin like receptor C3 [ Homo sapiens (human) ]

Gene ID: 3823, updated on 12-Oct-2019

Summary

Official Symbol
KLRC3provided by HGNC
Official Full Name
killer cell lectin like receptor C3provided by HGNC
Primary source
HGNC:HGNC:6376
See related
Ensembl:ENSG00000205810 MIM:602892
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKG2E; NKG2-E
Summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 5.1), spleen (RPKM 3.6) and 8 other tissues See more
Orthologs

Genomic context

See KLRC3 in Genome Data Viewer
Location:
12p13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (10412315..10420595, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10564914..10573194, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928100 Neighboring gene KLRC4-KLRK1 readthrough Neighboring gene killer cell lectin like receptor K1 Neighboring gene killer cell lectin like receptor C4 Neighboring gene killer cell lectin like receptor C2 Neighboring gene killer cell lectin like receptor C1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: KLRC2

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular defense response TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NKG2-E type II integral membrane protein
Names
NK cell receptor E
NKG2-E-activating NK receptor
killer cell lectin-like receptor subfamily C, member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029682.1 RefSeqGene

    Range
    5001..13281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002261.2NP_002252.2  NKG2-E type II integral membrane protein isoform E

    See identical proteins and their annotated locations for NP_002252.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as NKG2-E, represents the longer transcript but encodes the shorter isoform (E).
    Source sequence(s)
    AC068775, AF461157, L14542
    Consensus CDS
    CCDS41755.1
    UniProtKB/Swiss-Prot
    Q07444
    Related
    ENSP00000379716.2, ENST00000396439.6
    Conserved Domains (1) summary
    cd03593
    Location:117224
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  2. NM_007333.2NP_031359.2  NKG2-E type II integral membrane protein isoform H

    See identical proteins and their annotated locations for NP_031359.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as NKG2-H, uses an alternate splice site and lacks an exon in the 3' coding region, compared to variant 1. The resulting protein (isoform H) contains a distinct C-terminus, compared to isoform E.
    Source sequence(s)
    AC068775, AF078550, L14542
    Consensus CDS
    CCDS31744.1
    UniProtKB/Swiss-Prot
    Q07444
    Related
    ENSP00000371328.2, ENST00000381903.2
    Conserved Domains (1) summary
    cd03593
    Location:117227
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    10412315..10420595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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