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ARF6 ADP ribosylation factor 6 [ Homo sapiens (human) ]

Gene ID: 382, updated on 19-Jan-2019

Summary

Official Symbol
ARF6provided by HGNC
Official Full Name
ADP ribosylation factor 6provided by HGNC
Primary source
HGNC:HGNC:659
See related
Ensembl:ENSG00000165527 MIM:600464
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 54.5), colon (RPKM 38.8) and 25 other tissues See more
Orthologs

Genomic context

See ARF6 in Genome Data Viewer
Location:
14q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (49893018..49897054)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (50359736..50363772)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378179 Neighboring gene RNA, 7SL, cytoplasmic 3 Neighboring gene RNA, 7SL, cytoplasmic 2 Neighboring gene RNA, U6 small nuclear 189, pseudogene Neighboring gene uncharacterized LOC100506446

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ADP-ribosylation factor 6 (ARF6) by siRNAs significantly enhances HIV-1 replication in human acute monocytic leukemia cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ADP-ribosylation factor 6 (ARF6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Envelope surface glycoprotein gp160, precursor env GDP-bound or GTP-bound inactive Arf6 mutants or siRNA-mediated Arf6 silencing inhibit HIV-1 envelope-induced membrane fusion, entry, and infection of T lymphocytes and permissive cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ADP-ribosylation factor 6 (ARF6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ADP-ribosylation factor 6 (ARF6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
nef ARF6(T27N) and ARF6(Q67L) mutants induce significant reversal of HLA-I A2 downregulation by HIV-1 Nef through redistributing HLA-I A2 from the perinuclear vesicles to the peripheral punctate vesicles at the plasma membrane PubMed
nef The interaction of HIV-1 Nef and phosphatidylinositol-3-kinase (PI3K) activates the expression of ADP-ribosylation factor 6 (ARF6) in human melanoma cells PubMed
nef HIV-1 Nef-mediated downregulation of MHC-I has been reported to be regulated by ARF6, however a separate report indicates the apparent Arf6 dependency of Nef-mediated MHC class I down-modulation is due to nonspecific perturbations in membrane traffic PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ADP-ribosylation factor 6 (ARF6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
gag Overexpression of an active form of Arf6 (Arf6/Q67L), which induces the formation of PI(4,5)P2-enriched endosomal structures, severely reduces HIV-1 Gag virus production by redirecting Gag to PI(4,5)P2-enriched vesicles PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564M0264

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding TAS
Traceable Author Statement
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
PubMed 
protein N-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thioesterase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to nerve growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cortical actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytic recycling IDA
Inferred from Direct Assay
more info
PubMed 
establishment of epithelial cell polarity IEA
Inferred from Electronic Annotation
more info
 
hepatocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
liver development IEA
Inferred from Electronic Annotation
more info
 
maintenance of postsynaptic density structure IEA
Inferred from Electronic Annotation
more info
 
myeloid cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dendrite development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein localization to cell surface IEA
Inferred from Electronic Annotation
more info
 
negative regulation of receptor-mediated endocytosis TAS
Traceable Author Statement
more info
PubMed 
positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of adherens junction organization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of keratinocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to endosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of Rac protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
regulation of dendritic spine development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of filopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of presynapse assembly IEA
Inferred from Electronic Annotation
more info
 
ruffle assembly IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Flemming body IDA
Inferred from Direct Assay
more info
PubMed 
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
endosome TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 
filopodium membrane IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
presynapse IEA
Inferred from Electronic Annotation
more info
 
recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome membrane TAS
Traceable Author Statement
more info
 
ruffle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor 6
NP_001654.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001663.4NP_001654.1  ADP-ribosylation factor 6

    See identical proteins and their annotated locations for NP_001654.1

    Status: REVIEWED

    Source sequence(s)
    BC008918, BC030291, BM838197, DA217686
    Consensus CDS
    CCDS9695.1
    UniProtKB/Swiss-Prot
    P62330
    Related
    ENSP00000298316.5, ENST00000298316.6
    Conserved Domains (1) summary
    smart00177
    Location:1175
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    49893018..49897054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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