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Arf6 ADP-ribosylation factor 6 [ Mus musculus (house mouse) ]

Gene ID: 11845, updated on 18-Apr-2024

Summary

Official Symbol
Arf6provided by MGI
Official Full Name
ADP-ribosylation factor 6provided by MGI
Primary source
MGI:MGI:99435
See related
Ensembl:ENSMUSG00000044147 AllianceGenome:MGI:99435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables protein N-terminus binding activity. Involved in several processes, including negative regulation of protein localization to cell surface; positive regulation of focal adhesion disassembly; and positive regulation of keratinocyte migration. Acts upstream of or within several processes, including hepatocyte apoptotic process; liver development; and myeloid cell apoptotic process. Located in endosome and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system; and respiratory system. Orthologous to human ARF6 (ADP ribosylation factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 90.2), colon adult (RPKM 84.0) and 28 other tissues See more
Orthologs
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Genomic context

Location:
12 C2; 12 28.81 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69418924..69422754)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69372150..69375980)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E600 Neighboring gene STARR-seq mESC enhancer starr_32366 Neighboring gene STARR-positive B cell enhancer ABC_E10755 Neighboring gene 7S RNA 2 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:70523938-70524137 Neighboring gene STARR-positive B cell enhancer ABC_E8486 Neighboring gene STARR-positive B cell enhancer ABC_E11513 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:70559664-70559829 Neighboring gene RIKEN cDNA 5830428M24 gene Neighboring gene predicted gene, 40434 Neighboring gene STARR-positive B cell enhancer mm9_chr12:70576247-70576548

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102530

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity ISO
Inferred from Sequence Orthology
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding TAS
Traceable Author Statement
more info
PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables thioesterase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to nerve growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within erythrocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of epithelial cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hepatocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of postsynaptic density structure ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of keratinocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitotic cytokinetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to endosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to endosome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dendritic spine development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of presynapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of toll-like receptor 4 signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in ruffle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Flemming body ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome TAS
Traceable Author Statement
more info
PubMed 
located_in filopodium membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in ruffle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ADP-ribosylation factor 6
NP_031507.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007481.3NP_031507.1  ADP-ribosylation factor 6

    See identical proteins and their annotated locations for NP_031507.1

    Status: VALIDATED

    Source sequence(s)
    AC157822, AV587828, CJ167311
    Consensus CDS
    CCDS25952.1
    UniProtKB/Swiss-Prot
    P62331
    UniProtKB/TrEMBL
    Q3U0D7
    Related
    ENSMUSP00000055862.8, ENSMUST00000050063.9
    Conserved Domains (1) summary
    smart00177
    Location:1175
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    69418924..69422754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)