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Zfp408 zinc finger protein 408 [ Mus musculus (house mouse) ]

Gene ID: 381410, updated on 30-Apr-2024

Summary

Official Symbol
Zfp408provided by MGI
Official Full Name
zinc finger protein 408provided by MGI
Primary source
MGI:MGI:2685857
See related
Ensembl:ENSMUSG00000075040 AllianceGenome:MGI:2685857
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1011
Summary
Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 6 and retinitis pigmentosa 72. Orthologous to human ZNF408 (zinc finger protein 408). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 13.6), ovary adult (RPKM 8.7) and 28 other tissues See more
Orthologs
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Genomic context

See Zfp408 in Genome Data Viewer
Location:
2 E1; 2 50.63 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (91473101..91480372, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91642756..91650051, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cytoskeleton associated protein 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:91475064-91475265 Neighboring gene coagulation factor II Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:91486007-91486292 Neighboring gene STARR-positive B cell enhancer ABC_E1007 Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial pseudogene Neighboring gene Rho GTPase activating protein 1 Neighboring gene STARR-seq mESC enhancer starr_05121 Neighboring gene autophagy related 13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033451.4NP_001028623.1  zinc finger protein 408 isoform 2

    See identical proteins and their annotated locations for NP_001028623.1

    Status: VALIDATED

    Source sequence(s)
    AL691489
    Consensus CDS
    CCDS16436.1
    UniProtKB/TrEMBL
    B7ZP32, Q3V1D8
    Related
    ENSMUSP00000106965.2, ENSMUST00000111333.2
    Conserved Domains (3) summary
    COG5048
    Location:158407
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:361381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl40432
    Location:372
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
  2. NM_001347175.3NP_001334104.1  zinc finger protein 408 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL691489
    Consensus CDS
    CCDS84551.1
    UniProtKB/TrEMBL
    B7ZP32, H7BX78
    Related
    ENSMUSP00000097301.4, ENSMUST00000099714.10
  3. NM_001410208.1NP_001397137.1  zinc finger protein 408 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL691489
    UniProtKB/TrEMBL
    Q3V1D8
  4. NM_001410209.1NP_001397138.1  zinc finger protein 408 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL691489
    UniProtKB/TrEMBL
    Q3V1D8
  5. NM_001410210.1NP_001397139.1  zinc finger protein 408 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL691489
  6. NM_001410211.1NP_001397140.1  zinc finger protein 408 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL691489
  7. NM_001410212.1NP_001397141.1  zinc finger protein 408 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL691489
  8. NM_001410213.1NP_001397142.1  zinc finger protein 408 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL691489
  9. NM_001410214.1NP_001397143.1  zinc finger protein 408 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL691489
  10. NM_001410215.1NP_001397144.1  zinc finger protein 408 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL691489
  11. NM_001410216.1NP_001397145.1  zinc finger protein 408 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL691489
  12. NM_001410217.1NP_001397146.1  zinc finger protein 408 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL691489
  13. NM_001410218.1NP_001397147.1  zinc finger protein 408 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL691489

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    91473101..91480372 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)