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KIR2DL2 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2 [ Homo sapiens (human) ]

Gene ID: 3803, updated on 8-Jul-2018
Official Symbol
KIR2DL2provided by HGNC
Official Full Name
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2provided by HGNC
Primary source
HGNC:HGNC:6330
See related
MIM:604937
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKAT6; p58.2; CD158b; NKAT-6; CD158B1
Summary
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Annotation information
Annotation category: only annotated on alternate loci and patches unit in reference assembly
See KIR2DL2 in Genome Data Viewer
Location:
19q13.4
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 (ALT_REF_LOCI_35) NT_113949.2 (106541..121079, complement)
109 current GRCh38.p12 (GCF_000001405.38) 19 (ALT_REF_LOCI_10) NT_187636.1 (177968..192511, complement)
109 current GRCh38.p12 (GCF_000001405.38) 19 (ALT_REF_LOCI_12) NT_187638.1 (86166..100707, complement)
109 current GRCh38.p12 (GCF_000001405.38) 19 (ALT_REF_LOCI_14) NT_187640.1 (133429..147938, complement)
109 current GRCh38.p12 (GCF_000001405.38) 19 (ALT_REF_LOCI_16) NT_187642.1 (84686..99227, complement)
109 current GRCh38.p12 (GCF_000001405.38) 19 (ALT_REF_LOCI_18) NT_187644.1 (113612..128145, complement)
109 current GRCh38.p12 (GCF_000001405.38) 19 (ALT_REF_LOCI_20) NT_187668.1 (134349..148890, complement)
109 current GRCh38.p12 (GCF_000001405.38) 19 (ALT_REF_LOCI_22) NT_187670.1 (113704..128233, complement)
109 current GRCh38.p12 (GCF_000001405.38) 19 (ALT_REF_LOCI_27) NT_187675.1 (53236..67782)
109 current GRCh38.p12 (GCF_000001405.38) 19 (ALT_REF_LOCI_29) NT_187677.1 (45681..60217)
109 current GRCh38.p12 (GCF_000001405.38) 19 (ALT_REF_LOCI_33) NT_187686.1 (144844..159387, complement)
109 current GRCh38.p12 (GCF_000001405.38) 19 (ALT_REF_LOCI_3) NW_003571056.2 (737413..751952)
109 current GRCh38.p12 (GCF_000001405.38) 19 (ALT_REF_LOCI_8) NW_003571061.2 (480740..495279)
109 current GRCh38.p12 (GCF_000001405.38) 19 (PATCHES) NW_016107310.1 (42278..56765)
109 current GRCh38.p12 (GCF_000001405.38) 19 (PATCHES) NW_016107312.1 (108327..122858, complement)
109 current GRCh38.p12 (GCF_000001405.38) 19 (PATCHES) NW_016107314.1 (56304..70841)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NT_113949.1 (21890..36439)

NT_187636.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3

NT_187638.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains pseudogene 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3

NT_187640.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3

NT_187642.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains pseudogene 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3

NT_187644.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains pseudogene 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3

NT_187668.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3

NT_187670.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains pseudogene 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3

NT_187675.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3

NT_187677.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains pseudogene 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4

NW_003571056.2Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin-like receptor subfamily B member 3 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4

NT_187686.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3

NT_113949.2Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains pseudogene 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3

NW_003571061.2Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains pseudogene 1 Neighboring gene natural cytotoxicity triggering receptor 1

NW_016107314.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3 Neighboring gene killer cell immunoglobulin-like receptor 2DS2 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains pseudogene 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4

NW_016107312.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5 Neighboring gene killer cell immunoglobulin-like receptor 2DL5A Neighboring gene killer cell immunoglobulin-like receptor 2DS2 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3

NW_016107310.1Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin-like receptor pseudogene 2 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Amino-acid polymorphisms at positions W17 and M20 in HIV-1 Env inhibit KIR2DL2 in NK cells to recognize and bind to HIV-1-infected cells PubMed
Nef nef Amino-acid polymorphisms at positions S9 and L138 in HIV-1 Nef and Gag, respectively, inhibit KIR2DL2 in NK cells to recognize and bind to HIV-1-infected cells PubMed
Pr55(Gag) gag HIV-1 Gag peptides (Gag144-152, Gag163-171 and Gag295-304) enhance binding of KIR2DL2 to HLA-C03:04 and result in inhibition of KIR2DL2+ primary NK cells PubMed
gag HLA-C/HIV-1 Gag209-218 peptide complexes bind KIR2DL2, which results in functional inhibition of primary NK cells PubMed
gag Amino-acid polymorphisms at positions S9 and L138 in HIV-1 Nef and Gag, respectively, inhibit KIR2DL2 in NK cells to recognize and bind to HIV-1-infected cells PubMed
Vpu vpu Amino-acid polymorphisms at positions M71 and H74 in HIV-1 Vpu inhibit KIR2DL2 in NK cells to recognize and bind to HIV-1-infected cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
killer cell immunoglobulin-like receptor 2DL2
Names
CD158 antigen-like family member B1
MHC class I NK cell receptor
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
natural killer-associated transcript 6
p58 NK receptor CL-43
p58 natural killer cell receptor clone CL-43

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_005994.1 

    Range
    30696..45237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014219.2NP_055034.2  killer cell immunoglobulin-like receptor 2DL2 precursor

    See identical proteins and their annotated locations for NP_055034.2

    Status: REVIEWED

    Source sequence(s)
    AF285434, AY366242, U24075
    UniProtKB/Swiss-Prot
    P43627
    UniProtKB/TrEMBL
    Q6H2H0, Q8N742
    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_016107310.1 Reference GRCh38.p12 PATCHES

    Range
    42278..56765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_016107312.1 Reference GRCh38.p12 PATCHES

    Range
    108327..122858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_016107314.1 Reference GRCh38.p12 PATCHES

    Range
    56304..70841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_3

Genomic

  1. NW_003571056.2 Reference GRCh38.p12 ALT_REF_LOCI_3

    Range
    737413..751952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_8

Genomic

  1. NW_003571061.2 Reference GRCh38.p12 ALT_REF_LOCI_8

    Range
    480740..495279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_10

Genomic

  1. NT_187636.1 Reference GRCh38.p12 ALT_REF_LOCI_10

    Range
    177968..192511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_12

Genomic

  1. NT_187638.1 Reference GRCh38.p12 ALT_REF_LOCI_12

    Range
    86166..100707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_14

Genomic

  1. NT_187640.1 Reference GRCh38.p12 ALT_REF_LOCI_14

    Range
    133429..147938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_16

Genomic

  1. NT_187642.1 Reference GRCh38.p12 ALT_REF_LOCI_16

    Range
    84686..99227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_18

Genomic

  1. NT_187644.1 Reference GRCh38.p12 ALT_REF_LOCI_18

    Range
    113612..128145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_20

Genomic

  1. NT_187668.1 Reference GRCh38.p12 ALT_REF_LOCI_20

    Range
    134349..148890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_22

Genomic

  1. NT_187670.1 Reference GRCh38.p12 ALT_REF_LOCI_22

    Range
    113704..128233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_27

Genomic

  1. NT_187675.1 Reference GRCh38.p12 ALT_REF_LOCI_27

    Range
    53236..67782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_29

Genomic

  1. NT_187677.1 Reference GRCh38.p12 ALT_REF_LOCI_29

    Range
    45681..60217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_33

Genomic

  1. NT_187686.1 Reference GRCh38.p12 ALT_REF_LOCI_33

    Range
    144844..159387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_35

Genomic

  1. NT_113949.2 Reference GRCh38.p12 ALT_REF_LOCI_35

    Range
    106541..121079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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