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KCNK3 potassium two pore domain channel subfamily K member 3 [ Homo sapiens (human) ]

Gene ID: 3777, updated on 17-May-2020

Summary

Official Symbol
KCNK3provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 3provided by HGNC
Primary source
HGNC:HGNC:6278
See related
Ensembl:ENSG00000171303 MIM:603220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OAT1; PPH4; TASK; TASK1; TBAK1; K2p3.1; TASK-1
Summary
This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]
Expression
Biased expression in adrenal (RPKM 48.3), placenta (RPKM 12.8) and 5 other tissues See more
Orthologs

Genomic context

See KCNK3 in Genome Data Viewer
Location:
2p23.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (26692722..26733420)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (26915581..26954066)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene calcium and integrin binding family member 4 Neighboring gene ribosomal protein L37 pseudogene 11 Neighboring gene solute carrier family 35 member F6 Neighboring gene centromere protein A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu and TASK-1 decrease HIV-1 transcription by suppressing unintegrated HIV-1 DNA, which is inhibited by overexpression of RelA PubMed
vpu HIV-1 Vpu interacts with TASK-1, a mammalian background K(+) channel, which in turn suppresses TASK-1 current in HEK-293 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
S100 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ion channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
open rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
potassium channel activity TAS
Traceable Author Statement
more info
PubMed 
potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion leak channel activity IDA
Inferred from Direct Assay
more info
PubMed 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
brain development IEA
Inferred from Electronic Annotation
more info
 
cardiac conduction TAS
Traceable Author Statement
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to zinc ion IEA
Inferred from Electronic Annotation
more info
 
chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
cochlea development IEA
Inferred from Electronic Annotation
more info
 
ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
response to drug IEA
Inferred from Electronic Annotation
more info
 
stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
potassium channel subfamily K member 3
Names
TWIK-related acid-sensitive K(+) channel 1
TWIK-related acid-sensitive K+ 1
TWIK-related acid-sensitive K+ channel
acid-sensitive potassium channel protein TASK
acid-sensitive potassium channel protein TASK-1
cardiac potassium channel
potassium channel, two pore domain subfamily K, member 3
potassium inwardly-rectifying channel, subfamily K, member 3
two P domain potassium channel
two pore K(+) channel KT3.1
two pore potassium channel KT3.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033884.1 RefSeqGene

    Range
    5001..43486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002246.3NP_002237.1  potassium channel subfamily K member 3

    See identical proteins and their annotated locations for NP_002237.1

    Status: REVIEWED

    Source sequence(s)
    AC015977, AF065163
    Consensus CDS
    CCDS1727.1
    UniProtKB/Swiss-Prot
    O14649
    Related
    ENSP00000306275.3, ENST00000302909.4
    Conserved Domains (1) summary
    pfam07885
    Location:77132
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    26692722..26733420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264293.2XP_005264350.1  potassium channel subfamily K member 3 isoform X1

    See identical proteins and their annotated locations for XP_005264350.1

    Related
    ENSP00000483136.1, ENST00000620977.1
    Conserved Domains (2) summary
    pfam07885
    Location:57137
    Ion_trans_2; Ion channel
    cl01544
    Location:360
    Bestrophin; Bestrophin, RFP-TM, chloride channel
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