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Kcnk3 potassium channel, subfamily K, member 3 [ Mus musculus (house mouse) ]

Gene ID: 16527, updated on 12-May-2024

Summary

Official Symbol
Kcnk3provided by MGI
Official Full Name
potassium channel, subfamily K, member 3provided by MGI
Primary source
MGI:MGI:1100509
See related
Ensembl:ENSMUSG00000049265 AllianceGenome:MGI:1100509
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TASK; Task-1; cTBAK-1
Summary
Predicted to enable S100 protein binding activity; potassium channel activity; and protein C-terminus binding activity. Predicted to be involved in several processes, including negative regulation of cytosolic calcium ion concentration; potassium ion transmembrane transport; and stabilization of membrane potential. Predicted to act upstream of or within ion transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in early conceptus; heart; and secondary oocyte. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human KCNK3 (potassium two pore domain channel subfamily K member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 1700.1) and heart adult (RPKM 66.4) See more
Orthologs
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Genomic context

See Kcnk3 in Genome Data Viewer
Location:
5 B1; 5 16.68 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30745514..30782614)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30588170..30625270)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12752 Neighboring gene ciliary microtubule inner protein 2C Neighboring gene calcium and integrin binding family member 4 Neighboring gene predicted gene, 40272 Neighboring gene predicted gene 9899 Neighboring gene STARR-seq mESC enhancer starr_12757 Neighboring gene STARR-seq mESC enhancer starr_12759 Neighboring gene solute carrier family 35, member F6 Neighboring gene microRNA 5625 Neighboring gene STARR-positive B cell enhancer ABC_E4748 Neighboring gene centromere protein A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (6)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S100 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables open rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium ion leak channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of resting membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium channel subfamily K member 3
Names
TWIK-related acid-sensitive K(+) channel 1
acid-sensitive potassium channel protein TASK-1
cardiac two pore background K(+) channel
two pore K(+) channel KT3.1
two pore potassium channel KT3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010608.3NP_034738.1  potassium channel subfamily K member 3

    See identical proteins and their annotated locations for NP_034738.1

    Status: VALIDATED

    Source sequence(s)
    AC105298, AEKQ02160270
    Consensus CDS
    CCDS19160.1
    UniProtKB/Swiss-Prot
    O35111, O35163
    Related
    ENSMUSP00000098987.2, ENSMUST00000066295.5
    Conserved Domains (1) summary
    pfam07885
    Location:77132
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    30745514..30782614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)