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KCNJ14 potassium inwardly rectifying channel subfamily J member 14 [ Homo sapiens (human) ]

Gene ID: 3770, updated on 18-Aug-2020

Summary

Official Symbol
KCNJ14provided by HGNC
Official Full Name
potassium inwardly rectifying channel subfamily J member 14provided by HGNC
Primary source
HGNC:HGNC:6260
See related
Ensembl:ENSG00000182324 MIM:603953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRK4; KIR2.4
Summary
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]
Expression
Broad expression in testis (RPKM 1.5), skin (RPKM 1.2) and 21 other tissues See more
Orthologs

Genomic context

See KCNJ14 in Genome Data Viewer
Location:
19q13.33
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (48455574..48466980)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48958964..48969367)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor NMDA type subunit 2D Neighboring gene Sharpr-MPRA regulatory region 12315 Neighboring gene Sharpr-MPRA regulatory region 8588 Neighboring gene glutamate rich WD repeat containing 1 Neighboring gene cytohesin 2 Neighboring gene lemur tyrosine kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Potential readthrough

Included gene: GRWD1

Homology

Clone Names

  • KIAA1942, MGC46111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cardiac conduction TAS
Traceable Author Statement
more info
 
potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
dendrite IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
voltage-gated potassium channel complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ATP-sensitive inward rectifier potassium channel 14
Names
IRK-4
inward rectifier K(+) channel Kir2.4
inwardly rectifying potassium channel KIR2.4
potassium channel, inwardly rectifying subfamily J member 14
potassium voltage-gated channel subfamily J member 14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013348.4NP_037480.1  ATP-sensitive inward rectifier potassium channel 14

    See identical proteins and their annotated locations for NP_037480.1

    Status: VALIDATED

    Source sequence(s)
    AC008403, AF081466
    Consensus CDS
    CCDS12721.1
    UniProtKB/Swiss-Prot
    Q9UNX9
    Related
    ENSP00000341479.1, ENST00000342291.3
    Conserved Domains (1) summary
    pfam01007
    Location:53378
    IRK; Inward rectifier potassium channel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    48455574..48466980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_170720.1: Suppressed sequence

    Description
    NM_170720.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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