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GRWD1 glutamate rich WD repeat containing 1 [ Homo sapiens (human) ]

Gene ID: 83743, updated on 3-May-2020

Summary

Official Symbol
GRWD1provided by HGNC
Official Full Name
glutamate rich WD repeat containing 1provided by HGNC
Primary source
HGNC:HGNC:21270
See related
Ensembl:ENSG00000105447 MIM:610597
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDW4; GRWD; RRB1; WDR28
Summary
This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in placenta (RPKM 6.8), appendix (RPKM 6.7) and 25 other tissues See more
Orthologs

Genomic context

See GRWD1 in Genome Data Viewer
Location:
19q13.33
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (48445983..48457022)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48949030..48957164)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12315 Neighboring gene glutamate ionotropic receptor NMDA type subunit 2D Neighboring gene Sharpr-MPRA regulatory region 8588 Neighboring gene potassium inwardly rectifying channel subfamily J member 14 Neighboring gene cytohesin 2 Neighboring gene lemur tyrosine kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: KCNJ14

Homology

Clone Names

  • KIAA1942

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA replication origin binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleosome disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glutamate-rich WD repeat-containing protein 1
Names
CUL4- and DDB1-associated WDR protein 4
WD repeat domain 28
glutamate rich WD repeat protein GRWD
regulator of ribosome biogenesis 1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046925.1 RefSeqGene

    Range
    5001..13135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_031485.4NP_113673.3  glutamate-rich WD repeat-containing protein 1

    See identical proteins and their annotated locations for NP_113673.3

    Status: REVIEWED

    Source sequence(s)
    AC008403, BC002440, DA714522
    Consensus CDS
    CCDS12720.1
    UniProtKB/Swiss-Prot
    Q9BQ67
    Related
    ENSP00000253237.4, ENST00000253237.10
    Conserved Domains (4) summary
    COG2319
    Location:197383
    WD40; WD40 repeat [General function prediction only]
    pfam12265
    Location:44111
    CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
    sd00039
    Location:218259
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:204384
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    48445983..48457022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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