Kcnj14 potassium inwardly-rectifying channel, subfamily J, member 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnj14provided by MGI
Official Full Name: potassium inwardly-rectifying channel, subfamily J, member 14provided by MGI
Primary source: MGI:MGI:2384820
See related: Ensembl:ENSMUSG00000058743 AllianceGenome:MGI:2384820
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IRK4; Kir2.4; A930026G01Rik
Summary: Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of ion transmembrane transport. Predicted to act upstream of or within ion transport. Predicted to be located in dendrite and neuronal cell body. Predicted to be active in plasma membrane. Is expressed in several structures, including eye; jaw; limb; nervous system; and oral epithelium. Orthologous to human KCNJ14 (potassium inwardly rectifying channel subfamily J member 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 4.2), subcutaneous fat pad adult (RPKM 4.1) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 29.53 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (45465871..45474180, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45816467..45824747, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that rectifying potassium channel Kir2.4 interacts with G-protein subunit Galphao.
Title: Kir2.4 surface expression and basal current are affected by heterotrimeric G-proteins.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables inward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ATP-sensitive inward rectifier potassium channel 14

Names: IRK-4; inward rectifier K(+) channel Kir2.4; potassium channel, inwardly rectifying subfamily J member 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145963.3 → NP_666075.1 ATP-sensitive inward rectifier potassium channel 14

See identical proteins and their annotated locations for NP_666075.1

Status: VALIDATED

Source sequence(s)

AC149053

Consensus CDS

CCDS21265.1

UniProtKB/Swiss-Prot

Q8BMK3, Q8BXM0, Q8JZN3

Related

ENSMUSP00000071829.6, ENSMUST00000071937.7

Conserved Domains (2) summary

pfam01007
Location:51 → 189

IRK; Inward rectifier potassium channel

pfam17655
Location:196 → 369

IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

45465871..45474180 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152872.1 → XP_036008765.1 ATP-sensitive inward rectifier potassium channel 14 isoform X1

UniProtKB/Swiss-Prot

Q8BMK3, Q8BXM0, Q8JZN3

Conserved Domains (2) summary

pfam01007
Location:51 → 189

IRK; Inward rectifier potassium channel

pfam17655
Location:196 → 369

IRK_C; Inward rectifier potassium channel C-terminal domain