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SPATA21 spermatogenesis associated 21 [ Homo sapiens (human) ]

Gene ID: 374955, updated on 5-Aug-2022

Summary

Official Symbol
SPATA21provided by HGNC
Official Full Name
spermatogenesis associated 21provided by HGNC
Primary source
HGNC:HGNC:28026
See related
Ensembl:ENSG00000187144 AllianceGenome:HGNC:28026
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
spergen2; spergen-2
Summary
Predicted to enable calcium ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 12.4), duodenum (RPKM 11.2) and 25 other tissues See more
Orthologs
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Genomic context

See SPATA21 in Genome Data Viewer
Location:
1p36.13
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (16395677..16437842, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (15837210..15879103, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (16722172..16763919, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene F-box protein 42 Neighboring gene ribosomal protein L22 pseudogene 3 Neighboring gene SUZ RNA binding domain containing 1 Neighboring gene NECAP endocytosis associated 2 Neighboring gene long intergenic non-protein coding RNA 1772 Neighboring gene CROCC pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC27074

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
spermatogenesis-associated protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353349.1NP_001340278.1  spermatogenesis-associated protein 21 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AY327405, BC150598
    Consensus CDS
    CCDS85935.1
    Related
    ENSP00000440046.1, ENST00000540400.1
    Conserved Domains (2) summary
    cd00051
    Location:203262
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl27427
    Location:56144
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  2. NM_198546.1NP_940948.1  spermatogenesis-associated protein 21 isoform 1

    See identical proteins and their annotated locations for NP_940948.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AY327405
    Consensus CDS
    CCDS172.1
    UniProtKB/Swiss-Prot
    F5GXP5, Q7Z572
    Related
    ENSP00000335612.1, ENST00000335496.5
    Conserved Domains (1) summary
    cd00051
    Location:226285
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RNA

  1. NR_148413.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK128106, AL358794, AY327405
    Related
    ENST00000466212.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    16395677..16437842 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541407.4XP_011539709.1  spermatogenesis-associated protein 21 isoform X1

    See identical proteins and their annotated locations for XP_011539709.1

    Conserved Domains (1) summary
    cd00051
    Location:452511
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. XM_047419694.1XP_047275650.1  spermatogenesis-associated protein 21 isoform X4

  3. XM_017001218.2XP_016856707.1  spermatogenesis-associated protein 21 isoform X2

  4. XM_011541417.3XP_011539719.1  spermatogenesis-associated protein 21 isoform X3

    Conserved Domains (2) summary
    PTZ00184
    Location:449496
    PTZ00184; calmodulin; Provisional
    PHA03247
    Location:159384
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. XR_946645.2 RNA Sequence

  2. XR_001737156.2 RNA Sequence

  3. XR_946646.4 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791756.1 Reference GRCh38.p14 PATCHES

    Range
    199818..241687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    15837210..15879103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)