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ITPKA inositol-trisphosphate 3-kinase A [ Homo sapiens (human) ]

Gene ID: 3706, updated on 18-Sep-2024

Summary

Official Symbol
ITPKAprovided by HGNC
Official Full Name
inositol-trisphosphate 3-kinase Aprovided by HGNC
Primary source
HGNC:HGNC:6178
See related
Ensembl:ENSG00000137825 MIM:147521; AllianceGenome:HGNC:6178
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IP3KA; IP3-3KA
Summary
Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]
Expression
Biased expression in brain (RPKM 9.4), duodenum (RPKM 6.8) and 5 other tissues See more
Orthologs
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Genomic context

See ITPKA in Genome Data Viewer
Location:
15q15.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (41493874..41503551)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (39300037..39309713)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41786072..41795749)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RTF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene RNA, U6 small nuclear 1169, pseudogene Neighboring gene uncharacterized LOC105370790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9282 Neighboring gene Sharpr-MPRA regulatory region 6351 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41784974-41785474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41785475-41785975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6359 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6360 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41804857-41805604 Neighboring gene leukocyte receptor tyrosine kinase Neighboring gene RNA polymerase II associated protein 1 Neighboring gene MPRA-validated peak2307 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41835695-41836276

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of inositol-trisphosphate 3-kinase A (ITPKA) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium/calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables inositol tetrakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inositol-1,4,5-trisphosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dendritic spine maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in inositol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in modification of postsynaptic actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inositol-trisphosphate 3-kinase A
Names
IP3 3-kinase A
IP3K A
inositol 1,4,5-trisphosphate 3-kinase A
insP 3-kinase A
NP_002211.1
XP_047288415.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002220.3NP_002211.1  inositol-trisphosphate 3-kinase A

    See identical proteins and their annotated locations for NP_002211.1

    Status: REVIEWED

    Source sequence(s)
    AC087721, DB543073, X54938
    Consensus CDS
    CCDS10076.1
    UniProtKB/Swiss-Prot
    P23677, Q8TAN3
    Related
    ENSP00000260386.5, ENST00000260386.7
    Conserved Domains (1) summary
    pfam03770
    Location:245455
    IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    41493874..41503551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432459.1XP_047288415.1  inositol-trisphosphate 3-kinase A isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    39300037..39309713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)