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Itpka inositol 1,4,5-trisphosphate 3-kinase A [ Mus musculus (house mouse) ]

Gene ID: 228550, updated on 2-Nov-2024

Summary

Official Symbol
Itpkaprovided by MGI
Official Full Name
inositol 1,4,5-trisphosphate 3-kinase Aprovided by MGI
Primary source
MGI:MGI:1333822
See related
Ensembl:ENSMUSG00000027296 AllianceGenome:MGI:1333822
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable phosphotransferase activity, alcohol group as acceptor and small GTPase binding activity. Acts upstream of or within inositol metabolic process and regulation of synaptic plasticity. Predicted to be located in cytoskeleton and dendritic spine. Predicted to be active in several cellular components, including glutamatergic synapse; nucleus; and postsynaptic actin cytoskeleton. Orthologous to human ITPKA (inositol-trisphosphate 3-kinase A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 64.0), frontal lobe adult (RPKM 40.2) and 8 other tissues See more
Orthologs
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Genomic context

See Itpka in Genome Data Viewer
Location:
2 E5; 2 59.97 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119572818..119581734)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119742337..119751253)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RTF1, Paf1/RNA polymerase II complex component Neighboring gene STARR-positive B cell enhancer ABC_E7852 Neighboring gene STARR-seq mESC enhancer starr_05489 Neighboring gene predicted gene, 25857 Neighboring gene leukocyte tyrosine kinase Neighboring gene RNA polymerase II associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_05495

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC28924

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium/calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium/calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables inositol tetrakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inositol-1,4,5-trisphosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inositol-1,4,5-trisphosphate 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables inositol-1,4,5-trisphosphate 3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inositol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in modification of postsynaptic actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
involved_in modification of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol phosphate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
inositol-trisphosphate 3-kinase A
Names
IP3 3-kinase A
IP3-kinase A
IP3K A
insP 3-kinase A
NP_666237.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146125.2NP_666237.1  inositol-trisphosphate 3-kinase A

    See identical proteins and their annotated locations for NP_666237.1

    Status: PROVISIONAL

    Source sequence(s)
    AL844536
    Consensus CDS
    CCDS16607.1
    UniProtKB/Swiss-Prot
    A2AQ20, Q8R071
    Related
    ENSMUSP00000028758.8, ENSMUST00000028758.8
    Conserved Domains (1) summary
    pfam03770
    Location:243453
    IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    119572818..119581734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)