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ITGB1 integrin subunit beta 1 [ Homo sapiens (human) ]

Gene ID: 3688, updated on 1-Jun-2020

Summary

Official Symbol
ITGB1provided by HGNC
Official Full Name
integrin subunit beta 1provided by HGNC
Primary source
HGNC:HGNC:6153
See related
Ensembl:ENSG00000150093 MIM:135630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA
Summary
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 292.8), gall bladder (RPKM 214.5) and 25 other tissues See more
Orthologs

Genomic context

See ITGB1 in Genome Data Viewer
Location:
10p11.22
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (32900318..32958230, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (33189246..33247293, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 7 Neighboring gene C1D nuclear receptor corepressor pseudogene 1 Neighboring gene uncharacterized LOC105376486 Neighboring gene small nucleolar RNA, H/ACA box 86 Neighboring gene ITGB1 divergent transcript Neighboring gene adenylate kinase 3 pseudogene 5 Neighboring gene MT-ND4L pseudogene 11 Neighboring gene RNA, 7SL, cytoplasmic 847, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env SLIT2 inhibits HIV-1 gp120-induced lymphatic hyperpermeability by blocking the interaction between Robo4 and integrin alpha5beta1 in human lymphatic endothelial cells PubMed
env HIV-1 Tat complexes with gp120 to induce entry of VLPs expressing R5- or X4-tropic Env into MDDCs, which involves alpha5beta1, alpha5beta3, and alpha5beta5 integrins PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with ITGB1; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed
Nef nef The yeast two-hybrid screen and the coimmunoprecipitation analysis identify the HIV-1 Nef interacting human protein integrin, beta 1 (ITGB1) in cells PubMed
Tat tat HIV-1 Tat-induced inhibition of IFN-gamma release is regulated by the interaction of Tat-RGD domain with alpha5beta1 and alpha5beta3 integrins in CD8+ T cells PubMed
tat Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution PubMed
tat HIV-1 Tat complexes with gp120 to induce entry of VLPs expressing R5- or X4-tropic Env into MDDCs, which involves alpha5beta1, alpha5beta3, and alpha5beta5 integrins PubMed
tat The KKR spatial domain (Lys12, Lys41, and Arg78) in HIV-1 Tat contributes to Tat-mediated cell adhesion via integrin beta 1 activation in a cell surface HSPG-dependent manner PubMed
tat Sulfated polymannuroguluronate, a novel anti-AIDS drug candidate, greatly arrests Tat-driven KDR phosphorylation and blocks the interaction between Tat and integrin beta1, thus inhibiting the phosphorylation of the kinases FAK, paxillin and MAPKs PubMed
tat HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells requires CXCR4, VEGFR1, and beta-integrins PubMed
tat HIV-1 Tat induces angiogenesis and cooperates in the development of AIDS-associated Kaposi sarcoma as a result of interactions with integrins alpha-5-beta-1 and alpha-v-beta 3 PubMed
tat The arginine-glycine-aspartic acid (RGD) sequence present at the carboxy-terminal of HIV-1 Tat mediates vascular cell and monocyte migration and invasion by binding to the alpha-5-beta-1 and alpha-v-beta-3 integrins PubMed
tat HIV-1 Tat induced monocyte invasion is inhibited by anti-beta integrin Ab or tissue inhibitor of metalloproteinase (TIMP), indicating an interaction with beta integrins and TIMP PubMed
tat IFN-gamma interacts with HIV-1 Tat to induce endothelial cells to proliferate and invade the extracellular matrix by upregulating the receptors for Tat (integrins alpha-5-beta-1 and alpha-v-beta-3), suggesting Tat and IFN-gamma play major roles in AIDS-KS PubMed
tat Interaction of HIV-1 Tat with alpha 5, beta 1, and alpha v subunits of surface integrin receptors mediates activation of CD4+ T cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of integrin, beta 1 (ITGB1, fibronectin receptor, CD29) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to C-X3-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to C-X3-C chemokine binding IDA
Inferred from Direct Assay
more info
PubMed 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
cadherin binding HDA PubMed 
cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
collagen binding involved in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
collagen binding involved in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
coreceptor activity TAS
Traceable Author Statement
more info
PubMed 
fibronectin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibronectin binding IDA
Inferred from Direct Assay
more info
PubMed 
fibronectin binding IPI
Inferred from Physical Interaction
more info
PubMed 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to laminin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein heterodimerization activity TAS
Traceable Author Statement
more info
PubMed 
protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell differentiation IC
Inferred by Curator
more info
PubMed 
CD40 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
axon extension IEA
Inferred from Electronic Annotation
more info
 
basement membrane organization IEA
Inferred from Electronic Annotation
more info
 
calcium-independent cell-matrix adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
cardiac muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion mediated by integrin ISS
Inferred from Sequence or Structural Similarity
more info
 
cell fate specification IEA
Inferred from Electronic Annotation
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration TAS
Traceable Author Statement
more info
PubMed 
cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell projection organization ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell adhesion mediated by integrin IEP
Inferred from Expression Pattern
more info
PubMed 
cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular defense response TAS
Traceable Author Statement
more info
PubMed 
cellular response to low-density lipoprotein particle stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
formation of radial glial scaffolds IEA
Inferred from Electronic Annotation
more info
 
germ cell migration IEA
Inferred from Electronic Annotation
more info
 
heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules TAS
Traceable Author Statement
more info
PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
lamellipodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
leukocyte cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
leukocyte tethering or rolling IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesodermal cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fibroblast migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of glutamate uptake involved in transmission of nerve impulse ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of wound healing IDA
Inferred from Direct Assay
more info
PubMed 
receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of collagen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
regulation of inward rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of spontaneous synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
sarcomere organization IEA
Inferred from Electronic Annotation
more info
 
NOT stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
cell surface HDA PubMed 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cleavage furrow IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
filopodium IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
glial cell projection ISS
Inferred from Sequence or Structural Similarity
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of synaptic membrane IEA
Inferred from Electronic Annotation
more info
 
integrin alpha1-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
integrin alpha10-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
integrin alpha11-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
integrin alpha2-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
integrin alpha3-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
integrin alpha5-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
integrin alpha7-beta1 complex IEA
Inferred from Electronic Annotation
more info
 
integrin alpha8-beta1 complex TAS
Traceable Author Statement
more info
PubMed 
integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intercalated disc IEA
Inferred from Electronic Annotation
more info
 
invadopodium membrane IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath abaxonal region IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex TAS
Traceable Author Statement
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome IEA
Inferred from Electronic Annotation
more info
 
ruffle TAS
Traceable Author Statement
more info
PubMed 
colocalizes_with ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 
ruffle membrane NAS
Non-traceable Author Statement
more info
PubMed 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
integrin beta-1
Names
glycoprotein IIa
integrin VLA-4 beta subunit
integrin beta 1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
very late activation protein, beta polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029012.1 RefSeqGene

    Range
    5136..63048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002211.4NP_002202.2  integrin beta-1 isoform 1A precursor

    See identical proteins and their annotated locations for NP_002202.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1A) represents the longest transcript and encodes the shorter isoform (1A). Both variants 1A and 1E encode the same isoform.
    Source sequence(s)
    AI261443, BM973433, BX537407, CX868374, DB063946, DB292597
    Consensus CDS
    CCDS7174.1
    UniProtKB/Swiss-Prot
    P05556
    Related
    ENSP00000303351.3, ENST00000302278.8
    Conserved Domains (3) summary
    pfam00362
    Location:34464
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:640727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:757795
    Integrin_b_cyt; Integrin beta cytoplasmic domain
  2. NM_033668.2NP_391988.1  integrin beta-1 isoform 1D precursor

    See identical proteins and their annotated locations for NP_391988.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1D) includes an alternate exon, known as exon D, which results in a frameshift in the 3' coding region, compared to variant 1A. The resulting isoform (1D) has a distinct and longer C-terminus, compared to isoform 1A. This variant lacks full-length transcript support; its exon combination is predicted based on partial human transcript alignments, homologous transcript alignments including full-length cow mRNA BC114107.1, and data in the literature, including PMIDs 7544298, 7545396, 8567725 and 11779688, which consider this to be a functionally significant variant. This variant lacks a 5' UTR due to alternative splicing choices upstream of the CDS, and uncertainty about which alternative promoter is used.
    Source sequence(s)
    AI261443, AL365203, AL710802, BM791591, BM973433, BX537407, CX871886, DA600874
    UniProtKB/Swiss-Prot
    P05556
    Related
    ENSP00000388694.1, ENST00000423113.5
    Conserved Domains (3) summary
    pfam00362
    Location:34464
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:640727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:757796
    Integrin_b_cyt; Integrin beta cytoplasmic domain
  3. NM_133376.2NP_596867.1  integrin beta-1 isoform 1A precursor

    See identical proteins and their annotated locations for NP_596867.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1E) differs in the 5' UTR compared to variant 1A. Both variants 1A and 1E encode the same isoform (1A). There are no publicly available full-length transcripts representing this variant; it is supported by partial transcript alignments and by full-length cloning and sequencing in PMID:8444890.
    Source sequence(s)
    AI261443, AL365203, BM973433, BX537407, CX868374, DB292597
    Consensus CDS
    CCDS7174.1
    UniProtKB/Swiss-Prot
    P05556
    Related
    ENSP00000379350.2, ENST00000396033.6
    Conserved Domains (3) summary
    pfam00362
    Location:34464
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:640727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:757795
    Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    32900318..32958230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033666.2: Suppressed sequence

    Description
    NM_033666.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_033667.2: Suppressed sequence

    Description
    NM_033667.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_033669.2: Suppressed sequence

    Description
    NM_033669.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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