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ITGB1 integrin subunit beta 1 [ Homo sapiens (human) ]

Gene ID: 3688, updated on 25-Nov-2021

Summary

Official Symbol
ITGB1provided by HGNC
Official Full Name
integrin subunit beta 1provided by HGNC
Primary source
HGNC:HGNC:6153
See related
Ensembl:ENSG00000150093 MIM:135630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA
Summary
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 292.8), gall bladder (RPKM 214.5) and 25 other tissues See more
Orthologs
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Genomic context

See ITGB1 in Genome Data Viewer
Location:
10p11.22
Exon count:
18
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (32900318..32958230, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (33189246..33247158, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 7 Neighboring gene C1D nuclear receptor corepressor pseudogene 1 Neighboring gene uncharacterized LOC105376486 Neighboring gene small nucleolar RNA, H/ACA box 86 Neighboring gene ITGB1 divergent transcript Neighboring gene adenylate kinase 3 pseudogene 5 Neighboring gene MT-ND4L pseudogene 11 Neighboring gene RNA, 7SL, cytoplasmic 847, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env SLIT2 inhibits HIV-1 gp120-induced lymphatic hyperpermeability by blocking the interaction between Robo4 and integrin alpha5beta1 in human lymphatic endothelial cells PubMed
env HIV-1 Tat complexes with gp120 to induce entry of VLPs expressing R5- or X4-tropic Env into MDDCs, which involves alpha5beta1, alpha5beta3, and alpha5beta5 integrins PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with ITGB1; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed
Nef nef The yeast two-hybrid screen and the coimmunoprecipitation analysis identify the HIV-1 Nef interacting human protein integrin, beta 1 (ITGB1) in cells PubMed
Tat tat HIV-1 Tat-induced inhibition of IFN-gamma release is regulated by the interaction of Tat-RGD domain with alpha5beta1 and alpha5beta3 integrins in CD8+ T cells PubMed
tat Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution PubMed
tat HIV-1 Tat complexes with gp120 to induce entry of VLPs expressing R5- or X4-tropic Env into MDDCs, which involves alpha5beta1, alpha5beta3, and alpha5beta5 integrins PubMed
tat The KKR spatial domain (Lys12, Lys41, and Arg78) in HIV-1 Tat contributes to Tat-mediated cell adhesion via integrin beta 1 activation in a cell surface HSPG-dependent manner PubMed
tat Sulfated polymannuroguluronate, a novel anti-AIDS drug candidate, greatly arrests Tat-driven KDR phosphorylation and blocks the interaction between Tat and integrin beta1, thus inhibiting the phosphorylation of the kinases FAK, paxillin and MAPKs PubMed
tat HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells requires CXCR4, VEGFR1, and beta-integrins PubMed
tat HIV-1 Tat induces angiogenesis and cooperates in the development of AIDS-associated Kaposi sarcoma as a result of interactions with integrins alpha-5-beta-1 and alpha-v-beta 3 PubMed
tat The arginine-glycine-aspartic acid (RGD) sequence present at the carboxy-terminal of HIV-1 Tat mediates vascular cell and monocyte migration and invasion by binding to the alpha-5-beta-1 and alpha-v-beta-3 integrins PubMed
tat HIV-1 Tat induced monocyte invasion is inhibited by anti-beta integrin Ab or tissue inhibitor of metalloproteinase (TIMP), indicating an interaction with beta integrins and TIMP PubMed
tat IFN-gamma interacts with HIV-1 Tat to induce endothelial cells to proliferate and invade the extracellular matrix by upregulating the receptors for Tat (integrins alpha-5-beta-1 and alpha-v-beta-3), suggesting Tat and IFN-gamma play major roles in AIDS-KS PubMed
tat Interaction of HIV-1 Tat with alpha 5, beta 1, and alpha v subunits of surface integrin receptors mediates activation of CD4+ T cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of integrin, beta 1 (ITGB1, fibronectin receptor, CD29) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to C-X3-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to C-X3-C chemokine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cadherin binding HDA PubMed 
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables collagen binding involved in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables collagen binding involved in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables coreceptor activity TAS
Traceable Author Statement
more info
PubMed 
enables fibronectin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibronectin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables fibronectin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding TAS
Traceable Author Statement
more info
PubMed 
contributes_to laminin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in B cell differentiation IC
Inferred by Curator
more info
PubMed 
involved_in CD40 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in axon extension IEA
Inferred from Electronic Annotation
more info
 
involved_in basement membrane organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within calcium-independent cell-matrix adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cardiac muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell adhesion mediated by integrin ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell fate specification IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell projection organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell-cell adhesion mediated by integrin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular defense response TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to low-density lipoprotein particle stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in formation of radial glial scaffolds IEA
Inferred from Electronic Annotation
more info
 
involved_in germ cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules TAS
Traceable Author Statement
more info
PubMed 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lamellipodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in leukocyte cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukocyte tethering or rolling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mesodermal cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in myoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in myoblast fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of fibroblast migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of glutamate uptake involved in transmission of nerve impulse ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of wound healing IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within_negative_effect reactive gliosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of collagen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of inward rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within_negative_effect regulation of spontaneous synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sarcomere organization IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
involved_in visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface HDA PubMed 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane TAS
Traceable Author Statement
more info
 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in glial cell projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of synaptic membrane IEA
Inferred from Electronic Annotation
more info
 
part_of integrin alpha1-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin alpha10-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin alpha11-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin alpha2-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin alpha3-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin alpha4-beta1 complex TAS
Traceable Author Statement
more info
PubMed 
part_of integrin alpha5-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin alpha5-beta1 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of integrin alpha7-beta1 complex IEA
Inferred from Electronic Annotation
more info
 
part_of integrin alpha8-beta1 complex TAS
Traceable Author Statement
more info
PubMed 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intercalated disc IEA
Inferred from Electronic Annotation
more info
 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath abaxonal region IEA
Inferred from Electronic Annotation
more info
 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
 
located_in ruffle TAS
Traceable Author Statement
more info
PubMed 
colocalizes_with ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
integrin beta-1
Names
glycoprotein IIa
integrin VLA-4 beta subunit
integrin beta 1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
very late activation protein, beta polypeptide

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029012.1 RefSeqGene

    Range
    5136..63048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002211.4NP_002202.2  integrin beta-1 isoform 1A precursor

    See identical proteins and their annotated locations for NP_002202.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1A) represents the longest transcript and encodes the shorter isoform (1A). Both variants 1A and 1E encode the same isoform.
    Source sequence(s)
    AI261443, BM973433, BX537407, CX868374, DB063946, DB292597
    Consensus CDS
    CCDS7174.1
    UniProtKB/Swiss-Prot
    P05556
    Related
    ENSP00000303351.3, ENST00000302278.8
    Conserved Domains (5) summary
    smart00187
    Location:34464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:640727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:755795
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:466495
    I-EGF_1; Integrin beta epidermal growth factor like domain 1
    NF033759
    Location:472650
    exchanger_TraA; outer membrane exchange protein TraA
  2. NM_033668.2NP_391988.1  integrin beta-1 isoform 1D precursor

    See identical proteins and their annotated locations for NP_391988.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1D) includes an alternate exon, known as exon D, which results in a frameshift in the 3' coding region, compared to variant 1A. The resulting isoform (1D) has a distinct and longer C-terminus, compared to isoform 1A. This variant lacks full-length transcript support; its exon combination is predicted based on partial human transcript alignments, homologous transcript alignments including full-length cow mRNA BC114107.1, and data in the literature, including PMIDs 7544298, 7545396, 8567725 and 11779688, which consider this to be a functionally significant variant. This variant lacks a 5' UTR due to alternative splicing choices upstream of the CDS, and uncertainty about which alternative promoter is used.
    Source sequence(s)
    AI261443, AL365203, AL710802, BM791591, BM973433, BX537407, CX871886, DA600874
    UniProtKB/Swiss-Prot
    P05556
    Related
    ENSP00000388694.1, ENST00000423113.5
    Conserved Domains (3) summary
    pfam00362
    Location:34464
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:640727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:757796
    Integrin_b_cyt; Integrin beta cytoplasmic domain
  3. NM_133376.3NP_596867.1  integrin beta-1 isoform 1A precursor

    See identical proteins and their annotated locations for NP_596867.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1E) differs in the 5' UTR compared to variant 1A. Both variants 1A and 1E encode the same isoform (1A). There are no publicly available full-length transcripts representing this variant; it is supported by partial transcript alignments and by full-length cloning and sequencing in PMID:8444890.
    Source sequence(s)
    AI261443, AL365203, BM973433, BX537407, CX868374, DB292597
    Consensus CDS
    CCDS7174.1
    UniProtKB/Swiss-Prot
    P05556
    Related
    ENSP00000379350.2, ENST00000396033.6
    Conserved Domains (5) summary
    smart00187
    Location:34464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:640727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:755795
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:466495
    I-EGF_1; Integrin beta epidermal growth factor like domain 1
    NF033759
    Location:472650
    exchanger_TraA; outer membrane exchange protein TraA

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    32900318..32958230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033666.2: Suppressed sequence

    Description
    NM_033666.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_033667.2: Suppressed sequence

    Description
    NM_033667.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_033669.2: Suppressed sequence

    Description
    NM_033669.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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