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Itgb1 integrin beta 1 (fibronectin receptor beta) [ Mus musculus (house mouse) ]

Gene ID: 16412, updated on 28-May-2024

Summary

Official Symbol
Itgb1provided by MGI
Official Full Name
integrin beta 1 (fibronectin receptor beta)provided by MGI
Primary source
MGI:MGI:96610
See related
Ensembl:ENSMUSG00000025809 AllianceGenome:MGI:96610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD29; Fnrb; gpIIa; Gm9863; 4633401G24Rik
Summary
Enables integrin binding activity. Contributes to laminin binding activity. Involved in several processes, including basement membrane organization; cellular response to low-density lipoprotein particle stimulus; and receptor internalization. Acts upstream of or within with a negative effect on reactive gliosis and regulation of spontaneous synaptic transmission. Acts upstream of or within several processes, including cell morphogenesis involved in differentiation; regulation of ion transmembrane transport; and striated muscle cell differentiation. Located in several cellular components, including Schaffer collateral - CA1 synapse; intercalated disc; and myelin sheath abaxonal region. Part of integrin alpha7-beta1 complex. Is integral component of synaptic membrane. Colocalizes with cytoplasmic vesicle and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and limb. Used to study Hirschsprung's disease. Orthologous to human ITGB1 (integrin subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 156.5), placenta adult (RPKM 75.5) and 22 other tissues See more
Orthologs
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Genomic context

See Itgb1 in Genome Data Viewer
Location:
8 E2; 8 76.09 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (129412135..129460060)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (128685654..128733579)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 26002 Neighboring gene STARR-seq mESC enhancer starr_23105 Neighboring gene coiled-coil domain containing 7A Neighboring gene predicted gene, 26100 Neighboring gene STARR-seq mESC enhancer starr_23108 Neighboring gene STARR-positive B cell enhancer mm9_chr8:131465278-131465579 Neighboring gene predicted gene, 22545

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Targeted (27)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to C-X3-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to C-X3-C chemokine binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables collagen binding involved in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
enables collagen binding involved in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
enables fibronectin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding involved in cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to laminin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to laminin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables laminin binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in CD40 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axon extension IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in basement membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium-independent cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell projection organization ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell-matrix adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to low-density lipoprotein particle stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within dendrite morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within formation of radial glial scaffolds IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within germ cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
involved_in maintenance of postsynaptic specialization structure ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within myoblast fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of Rho protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell projection organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of glutamate uptake involved in transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in protein transport within lipid bilayer ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within_negative_effect reactive gliosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of collagen catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of inward rectifier potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within_negative_effect regulation of spontaneous synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synapse pruning IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synapse pruning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to muscle activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tissue homeostasis ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within visual learning IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cerebellar climbing fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cerebellar climbing fiber to Purkinje cell synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in glial cell projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in glycinergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in hemidesmosome ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alpha1-beta1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alpha10-beta1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alpha11-beta1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alpha2-beta1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alpha3-beta1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alpha5-beta1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alpha7-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin alpha7-beta1 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of integrin alpha9-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin alpha9-beta1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alphav-beta1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of integrin complex ISO
Inferred from Sequence Orthology
more info
 
located_in intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath abaxonal region IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with ruffle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
integrin beta-1
Names
VLA-4 subunit beta
fibronectin receptor subunit beta

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010578.2NP_034708.1  integrin beta-1 precursor

    See identical proteins and their annotated locations for NP_034708.1

    Status: VALIDATED

    Source sequence(s)
    AC156608, BC050906
    Consensus CDS
    CCDS22791.1
    UniProtKB/Swiss-Prot
    F6R105, P09055, Q3TIW5, Q3TWH6, Q60993, Q61126, Q8BTU0, Q8BVU1
    Related
    ENSMUSP00000087457.6, ENSMUST00000090006.12
    Conserved Domains (5) summary
    smart00187
    Location:34464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07974
    Location:602630
    EGF_2; EGF-like domain
    pfam07965
    Location:640727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:757795
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:466495
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    129412135..129460060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)