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ITGAM integrin subunit alpha M [ Homo sapiens (human) ]

Gene ID: 3684, updated on 4-Oct-2020

Summary

Official Symbol
ITGAMprovided by HGNC
Official Full Name
integrin subunit alpha Mprovided by HGNC
Primary source
HGNC:HGNC:6149
See related
Ensembl:ENSG00000169896 MIM:120980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
Summary
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Expression
Biased expression in bone marrow (RPKM 72.3), appendix (RPKM 14.6) and 6 other tissues See more
Orthologs

Genomic context

See ITGAM in Genome Data Viewer
Location:
16p11.2
Exon count:
31
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (31259975..31332877)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31271288..31344213)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene PYCARD antisense RNA 1 Neighboring gene PYD and CARD domain containing Neighboring gene tripartite motif containing 72 Neighboring gene pyrin domain containing 1 Neighboring gene integrin subunit alpha X pseudogene Neighboring gene integrin subunit alpha X Neighboring gene integrin subunit alpha D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
GeneReviews: Not available
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
GeneReviews: Not available
Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.
GeneReviews: Not available
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
GeneReviews: Not available
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
GeneReviews: Not available
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
GeneReviews: Not available
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Anti-CD18 monoclonal antibodies completely block cell fusion between HIV-1 infected U-937 cells and MT-4 T cells, indicating participation of CD18, or of the protein complex CD11a-c/CD18, in addition to CD4, in the infection and cytopathic effect of HIV-1 PubMed
Nef nef HIV-1 Nef interacts with complement receptor 3 (CR3) in a manner that allows CR3 redistribution toward bacterial-induced pseudopods in macrophages PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of integrin, alpha M (ITGAM, CR3A) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
matrix gag HIV-1 MA co-localizes with beta2 integrin, alphaM and alphaX integrins in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117044

Gene Ontology Provided by GOA

Function Evidence Code Pubs
amyloid-beta binding IC
Inferred by Curator
more info
 
cargo receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to cargo receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
complement component C3b binding ISS
Inferred from Sequence or Structural Similarity
more info
 
heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
integrin binding NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
amyloid-beta clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway involved in cell-cell signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell adhesion via plasma-membrane adhesion molecules NAS
Non-traceable Author Statement
more info
PubMed 
complement-mediated synapse pruning ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
ectodermal cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
forebrain development ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
microglial cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of dopamine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
phagocytosis, engulfment ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of hippocampal neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of microglial cell mediated cytotoxicity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neutrophil degranulation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of prostaglandin-E synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein targeting to membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of superoxide anion generation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of superoxide anion generation ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor-mediated endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
toll-like receptor 4 signaling pathway TAS
Traceable Author Statement
more info
 
vertebrate eye-specific patterning ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell surface HDA PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integrin alphaM-beta2 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
integrin complex TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
plasma membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
specific granule membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
integrin alpha-M
Names
CD11 antigen-like family member B
CR-3 alpha chain
antigen CD11b (p170)
cell surface glycoprotein MAC-1 subunit alpha
complement component 3 receptor 3 subunit
integrin, alpha M (complement component 3 receptor 3 subunit)
leukocyte adhesion receptor MO1
macrophage antigen alpha polypeptide
neutrophil adherence receptor alpha-M subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011719.1 RefSeqGene

    Range
    5009..77911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1333

mRNA and Protein(s)

  1. NM_000632.4NP_000623.2  integrin alpha-M isoform 2 precursor

    See identical proteins and their annotated locations for NP_000623.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks one internal amino acid, compared to isoform 1.
    Source sequence(s)
    AA436312, AC093520, AK057856, BC096348
    Consensus CDS
    CCDS45470.1
    UniProtKB/Swiss-Prot
    P11215
    Related
    ENSP00000441691.3, ENST00000544665.9
    Conserved Domains (4) summary
    smart00191
    Location:516562
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11291143
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:614978
    Integrin_alpha2; Integrin alpha
  2. NM_001145808.2NP_001139280.1  integrin alpha-M isoform 1 precursor

    See identical proteins and their annotated locations for NP_001139280.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC093520, BC096348, BM194233, J03925
    Consensus CDS
    CCDS54004.1
    UniProtKB/Swiss-Prot
    P11215
    Related
    ENSP00000496959.1, ENST00000648685.1
    Conserved Domains (4) summary
    smart00191
    Location:517563
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11301144
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:615979
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    31259975..31332877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023216.1XP_016878705.1  integrin alpha-M isoform X2

  2. XM_011545851.2XP_011544153.1  integrin alpha-M isoform X3

    Conserved Domains (2) summary
    smart00191
    Location:517563
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
  3. XM_006721045.1XP_006721108.1  integrin alpha-M isoform X4

    Conserved Domains (2) summary
    smart00191
    Location:516562
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
  4. XM_011545850.2XP_011544152.1  integrin alpha-M isoform X1

    Conserved Domains (4) summary
    smart00191
    Location:455501
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:87262
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:10681082
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:553917
    Integrin_alpha2; Integrin alpha

RNA

  1. XR_950796.1 RNA Sequence

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