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Itgam integrin alpha M [ Mus musculus (house mouse) ]

Gene ID: 16409, updated on 23-Jun-2021

Summary

Official Symbol
Itgamprovided by MGI
Official Full Name
integrin alpha Mprovided by MGI
Primary source
MGI:MGI:96607
See related
Ensembl:ENSMUSG00000030786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CR; CR3; CR3A; Ly-4; MAC1; Mac-; Cd11b; Ly-40; Mac-1; Mac-1a; CD11b/CD18; F730045J24Rik
Expression
Broad expression in liver E18 (RPKM 8.3), mammary gland adult (RPKM 7.7) and 23 other tissues See more
Orthologs
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Genomic context

See Itgam in Genome Data Viewer
Location:
7; 7 F3
Exon count:
30
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127661812..127717663)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (128062640..128118491)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (135206154..135262005)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing, X-linked 3 pseudogene Neighboring gene predicted gene, 22809 Neighboring gene predicted gene 45700 Neighboring gene integrin alpha X

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (3) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cargo receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
contributes_to cargo receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables complement component C3b binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables heparan sulfate proteoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables opsonin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables opsonin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in amyloid-beta clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in amyloid-beta clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor signaling pathway involved in cell-cell signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cellular extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to stress IC
Inferred by Curator
more info
PubMed 
involved_in complement-mediated synapse pruning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in forebrain development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukocyte adhesion to vascular endothelial cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within leukocyte migration involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within microglia development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microglial cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of dopamine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neutrophil apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hippocampal neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of mast cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of microglial cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neutrophil degranulation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oxidative stress-induced neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of prostaglandin-E synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of superoxide anion generation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of superoxide anion generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vertebrate eye-specific patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin alphaM-beta2 complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
integrin alpha-M
Names
CD11 antigen-like family member B
CD11B (p170)
CR-3 alpha chain
Mac-1 alpha
cell surface glycoprotein MAC-1 alpha subunit
cell surface glycoprotein MAC-1 subunit alpha
complement receptor type 3
leukocyte adhesion receptor MO1
macrophage antigen alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082960.1NP_001076429.1  integrin alpha-M isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC093175, AC124566
    Consensus CDS
    CCDS40149.1
    UniProtKB/TrEMBL
    G5E8F1
    Related
    ENSMUSP00000068468.9, ENSMUST00000064821.14
    Conserved Domains (4) summary
    smart00191
    Location:517558
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11311143
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:6151034
    Integrin_alpha2; Integrin alpha
  2. NM_008401.2NP_032427.2  integrin alpha-M isoform 2 precursor

    See identical proteins and their annotated locations for NP_032427.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AC093175, AC124566
    Consensus CDS
    CCDS21889.1
    UniProtKB/TrEMBL
    E9Q604
    Related
    ENSMUSP00000101849.5, ENSMUST00000106242.10
    Conserved Domains (4) summary
    smart00191
    Location:516557
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11301142
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:6141033
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    127661812..127717663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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