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EIF3E eukaryotic translation initiation factor 3 subunit E [ Homo sapiens (human) ]

Gene ID: 3646, updated on 1-Jun-2020

Summary

Official Symbol
EIF3Eprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Eprovided by HGNC
Primary source
HGNC:HGNC:3277
See related
Ensembl:ENSG00000104408 MIM:602210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT6; EIF3S6; EIF3-P48; eIF3-p46
Expression
Ubiquitous expression in ovary (RPKM 226.7), lymph node (RPKM 138.2) and 25 other tissues See more
Orthologs

Genomic context

See EIF3E in Genome Data Viewer
Location:
8q23.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (108201216..108248734, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (109213972..109260959, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene R-spondin 2 Neighboring gene nuclear receptor binding factor 2 pseudogene 4 Neighboring gene aurora kinase B pseudogene 1 Neighboring gene uncharacterized LOC105375704 Neighboring gene ribosomal protein S17 pseudogene 14 Neighboring gene ER membrane protein complex subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.
NHGRI GWA Catalog
Wnt signaling and Dupuytren's disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 3 subunit E protein (EIF3E), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 3 subunit E protein (EIF3E), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 3 subunit E protein (EIF3E), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit E (EIF3E) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 3 subunit E protein (EIF3E), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit E (EIF3E) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
 
negative regulation of translational initiation NAS
Non-traceable Author Statement
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mRNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
positive regulation of translation IPI
Inferred from Physical Interaction
more info
PubMed 
regulation of translational initiation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translational initiation IC
Inferred by Curator
more info
PubMed 
translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
colocalizes_with PML body IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with chromatin NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 
eukaryotic translation initiation factor 3 complex NAS
Non-traceable Author Statement
more info
PubMed 
eukaryotic translation initiation factor 3 complex, eIF3e IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nucleoplasm NAS
Non-traceable Author Statement
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit E
Names
eIF-3 p48
eukaryotic translation initiation factor 3 subunit 6
eukaryotic translation initiation factor 3 subunit E isoform 2 transcript
eukaryotic translation initiation factor 3, subunit 6 (48kD)
eukaryotic translation initiation factor 3, subunit 6 48kDa
mammary tumor-associated protein INT6
murine mammary tumor integration site 6 (oncogene homolog)
viral integration site protein INT-6 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001568.3NP_001559.1  eukaryotic translation initiation factor 3 subunit E

    See identical proteins and their annotated locations for NP_001559.1

    Status: VALIDATED

    Source sequence(s)
    AP001331, U62962
    Consensus CDS
    CCDS6308.1
    UniProtKB/Swiss-Prot
    P60228
    Related
    ENSP00000220849.5, ENST00000220849.10
    Conserved Domains (2) summary
    pfam01399
    Location:290394
    PCI; PCI domain
    pfam09440
    Location:5137
    eIF3_N; eIF3 subunit 6 N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    108201216..108248734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013398.2XP_016868887.2  eukaryotic translation initiation factor 3 subunit E isoform X1

    Conserved Domains (2) summary
    pfam01399
    Location:290394
    PCI; PCI domain
    pfam09440
    Location:5137
    eIF3_N; eIF3 subunit 6 N terminal domain
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