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Eif3e eukaryotic translation initiation factor 3, subunit E [ Mus musculus (house mouse) ]

Gene ID: 16341, updated on 12-May-2024

Summary

Official Symbol
Eif3eprovided by MGI
Official Full Name
eukaryotic translation initiation factor 3, subunit Eprovided by MGI
Primary source
MGI:MGI:99257
See related
Ensembl:ENSMUSG00000022336 AllianceGenome:MGI:99257
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Int6; 48kDa; Eif3s6; eIF3-p46; eIF3-p48
Summary
Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex. Is expressed in several structures, including genitourinary system; liver; mammary gland; spleen; and stomach. Orthologous to human EIF3E (eukaryotic translation initiation factor 3 subunit E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 59.0), placenta adult (RPKM 52.0) and 22 other tissues See more
Orthologs
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Genomic context

See Eif3e in Genome Data Viewer
Location:
15 B3.2; 15 16.73 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (43113436..43146132, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (43250040..43282736, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene R-spondin 2 Neighboring gene STARR-seq mESC enhancer starr_38549 Neighboring gene STARR-seq mESC enhancer starr_38550 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_38551 Neighboring gene STARR-seq mESC enhancer starr_38552 Neighboring gene predicted gene, 33743 Neighboring gene predicted gene 10373 Neighboring gene STARR-positive B cell enhancer mm9_chr15:43308481-43308782

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with PML body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of eukaryotic translation initiation factor 3 complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit E
Names
MMTV integration site 6
eukaryotic translation initiation factor 3, subunit 6 48kDa
mammary tumor integration site 6
mammary tumor-associated protein INT-6
viral integration site protein INT-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008388.2NP_032414.1  eukaryotic translation initiation factor 3 subunit E

    See identical proteins and their annotated locations for NP_032414.1

    Status: VALIDATED

    Source sequence(s)
    AA982184, AK161650, BY114098
    Consensus CDS
    CCDS27452.1
    UniProtKB/Swiss-Prot
    P60229
    UniProtKB/TrEMBL
    Q3UIG0, Q9CT23
    Related
    ENSMUSP00000022960.3, ENSMUST00000022960.4
    Conserved Domains (1) summary
    cd21378
    Location:3424
    eIF3E; eukaryotic translation initiation factor 3 subunit E

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    43113436..43146132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)