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ING2 inhibitor of growth family member 2 [ Homo sapiens (human) ]

Gene ID: 3622, updated on 7-Dec-2018

Summary

Official Symbol
ING2provided by HGNC
Official Full Name
inhibitor of growth family member 2provided by HGNC
Primary source
HGNC:HGNC:6063
See related
Ensembl:ENSG00000168556 MIM:604215
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ING1L; p33ING2
Summary
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in ovary (RPKM 10.5), adrenal (RPKM 8.4) and 25 other tissues See more
Orthologs

Genomic context

See ING2 in Genome Data Viewer
Location:
4q35.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (183505050..183512428)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (184426220..184433422)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene vesicle transport through interaction with t-SNAREs 1B pseudogene 2 Neighboring gene uncharacterized LOC389247 Neighboring gene uncharacterized LOC101929996 Neighboring gene uncharacterized LOC105377579 Neighboring gene uncharacterized LOC105377580

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • PI5P Regulates TP53 Acetylation, organism-specific biosystem (from REACTOME)
    PI5P Regulates TP53 Acetylation, organism-specific biosystemUnder conditions of cellular stress, nuclear levels of phosphatidylinositol-5-phosphate (PI5P) increase and, through interaction with ING2, result in nuclear retention/accumulation of ING2. ING2 bind...
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
  • Regulation of TP53 Activity through Acetylation, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Acetylation, organism-specific biosystemTranscriptional activity of TP53 is positively regulated by acetylation of several of its lysine residues. BRD7 binds TP53 and promotes acetylation of TP53 lysine residue K382 by acetyltransferase EP...
  • Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
    Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
male germ-line stem cell asymmetric division ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
male meiosis I ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator TAS
Traceable Author Statement
more info
PubMed 
positive regulation of histone deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cellular senescence NAS
Non-traceable Author Statement
more info
PubMed 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
regulation of response to DNA damage stimulus NAS
Non-traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
seminiferous tubule development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
CCAAT-binding factor complex IDA
Inferred from Direct Assay
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Sin3 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
inhibitor of growth protein 2
Names
ING1Lp
inhibitor of growth 1-like protein
p32

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291959.1NP_001278888.1  inhibitor of growth protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001278888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, resulting in translation initiation from an alternate start codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC107214, AK294310, BC030128
    UniProtKB/Swiss-Prot
    Q9H160
    Conserved Domains (2) summary
    cd15683
    Location:173221
    PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)
    pfam12998
    Location:1881
    ING; Inhibitor of growth proteins N-terminal histone-binding
  2. NM_001564.4NP_001555.1  inhibitor of growth protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001555.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB012853, AC107214, AK314000, BC030128
    Consensus CDS
    CCDS3833.1
    UniProtKB/Swiss-Prot
    Q9H160
    UniProtKB/TrEMBL
    B2RA15
    Related
    ENSP00000307183.3, ENST00000302327.3
    Conserved Domains (2) summary
    cd15683
    Location:213261
    PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)
    pfam12998
    Location:27121
    ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    183505050..183512428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531927.2XP_011530229.1  inhibitor of growth protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011530229.1

    Conserved Domains (2) summary
    cd15683
    Location:158206
    PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)
    pfam12998
    Location:366
    ING; Inhibitor of growth proteins N-terminal histone-binding
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