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Ing2 inhibitor of growth family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 69260, updated on 8-Dec-2022

Summary

Official Symbol
Ing2provided by MGI
Official Full Name
inhibitor of growth family, member 2provided by MGI
Primary source
MGI:MGI:1916510
See related
Ensembl:ENSMUSG00000063049 AllianceGenome:MGI:1916510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ing1l; Ing2b; P33ING2; 2810011M06Rik
Summary
Predicted to enable DNA binding activity; methylated histone binding activity; and phosphatidylinositol binding activity. Involved in several processes, including male gamete generation; positive regulation of histone deacetylation; and seminiferous tubule development. Acts upstream of or within negative regulation of apoptotic signaling pathway and positive regulation of transcription, DNA-templated. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of CCAAT-binding activity factor complex and Sin3 complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and immune system. Orthologous to human ING2 (inhibitor of growth family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 8.8), cortex adult (RPKM 5.3) and 28 other tissues See more
Orthologs
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Genomic context

See Ing2 in Genome Data Viewer
Location:
8; 8 B1.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (48120213..48128627, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (47667178..47675159, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 2 pseudogene Neighboring gene predicted gene 8623 Neighboring gene expressed sequence AA386476 Neighboring gene predicted gene, 31692 Neighboring gene predicted gene, 31638 Neighboring gene CDKN2A interacting protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male germ-line stem cell asymmetric division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell migration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histone deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of growth IEA
Inferred from Electronic Annotation
more info
 
involved_in seminiferous tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of CCAAT-binding factor complex ISO
Inferred from Sequence Orthology
more info
 
part_of Sin3 complex ISO
Inferred from Sequence Orthology
more info
 
part_of Sin3 complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
inhibitor of growth protein 2
Names
inhibitor of growth 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023503.3NP_075992.2  inhibitor of growth protein 2

    See identical proteins and their annotated locations for NP_075992.2

    Status: VALIDATED

    Source sequence(s)
    AC107236
    Consensus CDS
    CCDS22298.1
    UniProtKB/Swiss-Prot
    Q8BGU8, Q9ESK4
    Related
    ENSMUSP00000079226.3, ENSMUST00000080353.3
    Conserved Domains (3) summary
    COG5034
    Location:31260
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15683
    Location:214262
    PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)
    pfam12998
    Location:28122
    ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    48120213..48128627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154269.1XP_036010162.1  inhibitor of growth protein 2 isoform X1

    UniProtKB/TrEMBL
    B6ZI39
    Conserved Domains (1) summary
    cd15683
    Location:107155
    PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)
  2. XM_036154268.1XP_036010161.1  inhibitor of growth protein 2 isoform X1

    UniProtKB/TrEMBL
    B6ZI39
    Conserved Domains (1) summary
    cd15683
    Location:107155
    PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)