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Ppid peptidylprolyl isomerase D [ Rattus norvegicus (Norway rat) ]

Gene ID: 361967, updated on 17-Aug-2024

Summary

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Official Symbol
Ppidprovided by RGD
Official Full Name
peptidylprolyl isomerase Dprovided by RGD
Primary source
RGD:1303174
See related
EnsemblRapid:ENSRNOG00000027408 AllianceGenome:RGD:1303174
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CypD; Cyp-40
Summary
Enables cyclosporin A binding activity; enzyme binding activity; and peptidyl-prolyl cis-trans isomerase activity. Involved in several processes, including protein peptidyl-prolyl isomerization; regulation of mitochondrial membrane potential; and response to oxidative stress. Located in mitochondrion. Orthologous to human PPID (peptidylprolyl isomerase D). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: This gene encodes a 370 aa protein that is found in the cytoplasm. In some databases, it has been labeled incorrectly as 'cyclophilin D'. This same name has also been applied to a different protein, found in the mitochondrion, which is represented by GeneID 282819, Ppif. [13 Feb 2013]
Expression
Biased expression in Thymus (RPKM 324.9), Brain (RPKM 259.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q33
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (167025985..167037998)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (164727803..164740168)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (178354830..178366843)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485630 Neighboring gene sperm microtubule inner protein 2 Neighboring gene folliculin interacting protein 2 Neighboring gene electron transfer flavoprotein dehydrogenase Neighboring gene similar to human chromosome 4 open reading frame 46

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARα-cyclophilin D interaction in cardiomyocytes. Barreto-Torres G, et al. Am J Physiol Heart Circ Physiol, 2015 Apr 1. PMID 25617357, Free PMC Article
  2. Cyclophilin 40 alters UVA-induced apoptosis and mitochondrial ROS generation in keratinocytes. Jandova J, et al. Exp Cell Res, 2013 Mar 10. PMID 23220213, Free PMC Article
  3. N-methyl-4-isoleucine cyclosporine attenuates CCl -induced liver fibrosis in rats by interacting with cyclophilin B and D. Wang H, et al. J Gastroenterol Hepatol, 2011 Mar. PMID 21332552
  4. Human cyclophilin 40 is a heat shock protein that exhibits altered intracellular localization following heat shock. Mark PJ, et al. Cell Stress Chaperones, 2001 Jan. PMID 11525244, Free PMC Article
  5. Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner. Bourke CH, et al. Psychoneuroendocrinology, 2013 Jan. PMID 22647578, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In cardiomyocytes the protective effects of metformin-induced AMPK activation against oxidative stress converge on mitochondria and are mediated, at least in part, through the dissociation of PPARalpha-CypD interactions.
    Title: The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARα-cyclophilin D interaction in cardiomyocytes.
  2. Ppid expression was predicted by plasma estradiol & 34% lower in control adolescent females than males. After chronic adolescent stress, females had elevated hippocampal Ppid expression that was not seen in males.
    Title: Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner.
  3. NIM811 attenuates liver fibrosis in a CCl(4)-induced rat liver fibrosis model, which may be related to binding with cyclophilin B and D.
    Title: N-methyl-4-isoleucine cyclosporine attenuates CCl -induced liver fibrosis in rats by interacting with cyclophilin B and D.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC93768

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Hsp70 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables Hsp90 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclosporin A binding IDA
Inferred from Direct Assay
more info
  
enables cyclosporin A binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear estrogen receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to UV-A ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to UV-A ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
  
involved_in chaperone-mediated protein folding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid droplet organization ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid droplet organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
  
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase D
Names
40 kDa peptidyl-prolyl cis-trans isomerase
Cyclophilin D
PPIase D
cyclophilin-40
rotamase D
NP_001004279.1
XP_063138186.1
XP_063138187.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004279.1 → NP_001004279.1  peptidyl-prolyl cis-trans isomerase D

    See identical proteins and their annotated locations for NP_001004279.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076386
    UniProtKB/Swiss-Prot
    Q6DGG0
    UniProtKB/TrEMBL
    A0A8I6GKS0
    Related
    ENSRNOP00000093695.2, ENSRNOT00000097015.2
    Conserved Domains (3) summary
    cd01926
    Location:16 → 182
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
    TIGR00990
    Location:192 → 330
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:223 → 251
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    167025985..167037998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282116.1 → XP_063138186.1  peptidyl-prolyl cis-trans isomerase D isoform X1

    UniProtKB/TrEMBL
    A6J5S1

  2. XM_063282117.1 → XP_063138187.1  peptidyl-prolyl cis-trans isomerase D isoform X1

    UniProtKB/TrEMBL
    A6J5S1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DGG0.3 GenPept UniProtKB/Swiss-Prot:Q6DGG0

Gene LinkOut

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