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PPID peptidylprolyl isomerase D [ Homo sapiens (human) ]

Gene ID: 5481, updated on 11-Sep-2019

Summary

Official Symbol
PPIDprovided by HGNC
Official Full Name
peptidylprolyl isomerase Dprovided by HGNC
Primary source
HGNC:HGNC:9257
See related
Ensembl:ENSG00000171497 MIM:601753
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYPD; CYP-40
Summary
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]
Annotation information
Note: This gene encodes a 370 aa protein that is found in the cytoplasm. In some databases, it has been labeled incorrectly as 'cyclophilin D'. This same name has also been applied to a different protein, found in the mitochondrion, which is represented by Entrez GeneID 10105, PPIF. [13 Feb 2013]
Expression
Ubiquitous expression in testis (RPKM 15.6), duodenum (RPKM 13.0) and 25 other tissues See more
Orthologs

Genomic context

See PPID in Genome Data Viewer
Location:
4q32.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (158709127..158723396, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (159630279..159644552, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene relaxin family peptide receptor 1 Neighboring gene chromosome 4 open reading frame 46 Neighboring gene electron transfer flavoprotein dehydrogenase Neighboring gene RNA, U6 small nuclear 128, pseudogene Neighboring gene folliculin interacting protein 2 Neighboring gene chromosome 4 open reading frame 45 Neighboring gene proteasome activator subunit 2 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide perspective of genetic variation in human metabolism.
NHGRI GWA Catalog
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33096

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Hsp70 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Hsp90 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclosporin A binding IDA
Inferred from Direct Assay
more info
PubMed 
cyclosporin A binding TAS
Traceable Author Statement
more info
PubMed 
estrogen receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV-A IMP
Inferred from Mutant Phenotype
more info
PubMed 
chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
PubMed 
lipid droplet organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein peptidyl-prolyl isomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
viral release from host cell TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase D
Names
40 kDa peptidyl-prolyl cis-trans isomerase D
PPIase D
cyclophilin 40
cyclophilin D
cyclophilin-related protein
rotamase D
testicular tissue protein Li 147
NP_005029.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005038.3NP_005029.1  peptidyl-prolyl cis-trans isomerase D

    See identical proteins and their annotated locations for NP_005029.1

    Status: REVIEWED

    Source sequence(s)
    BC030707, BG699755, BU726810, L11667
    Consensus CDS
    CCDS3801.1
    UniProtKB/Swiss-Prot
    Q08752
    UniProtKB/TrEMBL
    E5KN55
    Related
    ENSP00000303754.3, ENST00000307720.4
    Conserved Domains (3) summary
    cd01926
    Location:16182
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    sd00006
    Location:224267
    TPR; TPR repeat [structural motif]
    cl26005
    Location:192362
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    158709127..158723396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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