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PPID peptidylprolyl isomerase D [ Homo sapiens (human) ]

Gene ID: 5481, updated on 17-Jun-2024

Summary

Official Symbol
PPIDprovided by HGNC
Official Full Name
peptidylprolyl isomerase Dprovided by HGNC
Primary source
HGNC:HGNC:9257
See related
Ensembl:ENSG00000171497 MIM:601753; AllianceGenome:HGNC:9257
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYPD; CYP-40
Summary
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]
Annotation information
Note: This gene encodes a 370 aa protein that is found in the cytoplasm. In some databases, it has been labeled incorrectly as 'cyclophilin D'. This same name has also been applied to a different protein, found in the mitochondrion, which is represented by Entrez GeneID 10105, PPIF. [13 Feb 2013]
Expression
Ubiquitous expression in testis (RPKM 15.6), duodenum (RPKM 13.0) and 25 other tissues See more
Orthologs
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Genomic context

See PPID in Genome Data Viewer
Location:
4q32.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (158709127..158723396, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (162059876..162074164, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (159630279..159644548, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:159592018-159592654 Neighboring gene H3K27ac hESC enhancers GRCh37_chr4:159592655-159593291 and GRCh37_chr4:159593295-159593796 Neighboring gene chromosome 4 open reading frame 46 Neighboring gene small nucleolar RNA U3 Neighboring gene electron transfer flavoprotein dehydrogenase Neighboring gene hESC enhancers GRCh37_chr4:159643958-159644541 and GRCh37_chr4:159644542-159645126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15773 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:159690086-159690823 Neighboring gene folliculin interacting protein 2 Neighboring gene Sharpr-MPRA regulatory region 12747 Neighboring gene RNA, U6 small nuclear 128, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:159766516-159767164 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:159802306-159803286 Neighboring gene Sharpr-MPRA regulatory region 14183 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:159823055-159823920 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:159823921-159824786 Neighboring gene uncharacterized LOC124900178 Neighboring gene sperm microtubule inner protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide perspective of genetic variation in human metabolism.
EBI GWAS Catalog
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC33096

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Hsp70 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables Hsp90 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclosporin A binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cyclosporin A binding TAS
Traceable Author Statement
more info
PubMed 
enables heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear estrogen receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase D
Names
40 kDa peptidyl-prolyl cis-trans isomerase D
PPIase D
cyclophilin 40
cyclophilin D
cyclophilin-related protein
rotamase D
testicular tissue protein Li 147
NP_005029.1
XP_047271800.1
XP_054206257.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005038.3NP_005029.1  peptidyl-prolyl cis-trans isomerase D

    See identical proteins and their annotated locations for NP_005029.1

    Status: REVIEWED

    Source sequence(s)
    BC030707, BG699755, BU726810, L11667
    Consensus CDS
    CCDS3801.1
    UniProtKB/Swiss-Prot
    B2R9V2, Q08752
    UniProtKB/TrEMBL
    E5KN55, E5KN59, Q6FGM6
    Related
    ENSP00000303754.3, ENST00000307720.4
    Conserved Domains (3) summary
    cd01926
    Location:16182
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    sd00006
    Location:224267
    TPR; TPR repeat [structural motif]
    cl26005
    Location:192362
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    158709127..158723396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047415844.1XP_047271800.1  peptidyl-prolyl cis-trans isomerase D isoform X1

    UniProtKB/TrEMBL
    Q05DH6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    162059876..162074164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350282.1XP_054206257.1  peptidyl-prolyl cis-trans isomerase D isoform X1

    UniProtKB/TrEMBL
    Q05DH6