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Ppid peptidylprolyl isomerase D (cyclophilin D) [ Mus musculus (house mouse) ]

Gene ID: 67738, updated on 9-May-2024

Summary

Official Symbol
Ppidprovided by MGI
Official Full Name
peptidylprolyl isomerase D (cyclophilin D)provided by MGI
Primary source
MGI:MGI:1914988
See related
Ensembl:ENSMUSG00000027804 AllianceGenome:MGI:1914988
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ppidl; CYP-40; 4930564J03Rik
Summary
Predicted to enable several functions, including Hsp90 protein binding activity; cyclosporin A binding activity; and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in several processes, including cellular response to UV-A; protein peptidyl-prolyl isomerization; and regulation of apoptotic process. Predicted to act upstream of or within apoptotic process and protein transport. Predicted to be located in cytosol; mitochondrion; and nuclear lumen. Predicted to be active in cytoplasm. Is expressed in embryo. Orthologous to human PPID (peptidylprolyl isomerase D). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: This gene encodes a 370 aa protein that is found in the cytoplasm. In some databases, it has been labeled incorrectly as 'cyclophilin D'. This same name has also been applied to a different protein, found in the mitochondrion, which is represented by Entrez GeneID 105675, Ppif. [09 Apr 2019]
Expression
Broad expression in CNS E11.5 (RPKM 29.1), liver E14 (RPKM 27.6) and 25 other tissues See more
Orthologs
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Genomic context

See Ppid in Genome Data Viewer
Location:
3 E3; 3 34.91 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (79498644..79511117)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (79591337..79603810)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sperm microtubule inner protein 2 Neighboring gene STARR-seq mESC enhancer starr_08000 Neighboring gene folliculin interacting protein 2 Neighboring gene STARR-seq mESC enhancer starr_08002 Neighboring gene RIKEN cDNA 4930589L23 gene Neighboring gene STARR-seq mESC enhancer starr_08006 Neighboring gene RIKEN cDNA 4930579G24 gene Neighboring gene electron transferring flavoprotein, dehydrogenase Neighboring gene relaxin/insulin-like family peptide receptor 1 Neighboring gene STARR-seq mESC enhancer starr_08007 Neighboring gene VISTA enhancer mm1650

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FK506 binding TAS
Traceable Author Statement
more info
PubMed 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclosporin A binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidyl-prolyl cis-trans isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV-A ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid droplet organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein peptidyl-prolyl isomerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase D
Names
40 kDa peptidyl-prolyl cis-trans isomerase
PPIase D
cyclophilin-40
cytoplasmic cyclophilin D
rotamase D
NP_001343255.1
NP_080628.1
XP_006502006.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356326.1NP_001343255.1  peptidyl-prolyl cis-trans isomerase D isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113945
    Conserved Domains (3) summary
    TIGR00990
    Location:98236
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:129157
    TPR; TPR repeat [structural motif]
    cl00197
    Location:1788
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
  2. NM_026352.4NP_080628.1  peptidyl-prolyl cis-trans isomerase D isoform 1

    See identical proteins and their annotated locations for NP_080628.1

    Status: VALIDATED

    Source sequence(s)
    AC113945
    Consensus CDS
    CCDS17417.1
    UniProtKB/Swiss-Prot
    Q543G1, Q9CR16
    UniProtKB/TrEMBL
    Q3UB60
    Related
    ENSMUSP00000029382.8, ENSMUST00000029382.13
    Conserved Domains (5) summary
    smart00028
    Location:277306
    TPR; Tetratricopeptide repeats
    cd01926
    Location:16182
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    sd00006
    Location:223251
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:308340
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:277338
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    79498644..79511117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501943.4XP_006502006.1  peptidyl-prolyl cis-trans isomerase D isoform X1

    See identical proteins and their annotated locations for XP_006502006.1

    Conserved Domains (3) summary
    TIGR00990
    Location:98236
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:129157
    TPR; TPR repeat [structural motif]
    cl00197
    Location:1788
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...