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IMPDH2 inosine monophosphate dehydrogenase 2 [ Homo sapiens (human) ]

Gene ID: 3615, updated on 3-May-2020

Summary

Official Symbol
IMPDH2provided by HGNC
Official Full Name
inosine monophosphate dehydrogenase 2provided by HGNC
Primary source
HGNC:HGNC:6053
See related
Ensembl:ENSG00000178035 MIM:146691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMPD2; IMPDH-II
Summary
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 136.8), skin (RPKM 49.4) and 25 other tissues See more
Orthologs

Genomic context

See IMPDH2 in Genome Data Viewer
Location:
3p21.31
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (49024325..49029750, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49061758..49066875, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene DALR anticodon binding domain containing 3 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 3 Neighboring gene microRNA 425 Neighboring gene microRNA 191 Neighboring gene glutamine rich 1 Neighboring gene RNA, 7SL, cytoplasmic 182, pseudogene Neighboring gene glutaminyl-tRNA synthetase 1 Neighboring gene microRNA 6890

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with IMPDH2 PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of IMP (inosine 5'-monophosphate) dehydrogenase 2 (IMPDH2) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
IMP dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
GMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
GTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to interleukin-4 IEA
Inferred from Electronic Annotation
more info
 
circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
lymphocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
purine ribonucleoside monophosphate biosynthetic process TAS
Traceable Author Statement
more info
 
retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
peroxisomal membrane HDA PubMed 
secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
inosine-5'-monophosphate dehydrogenase 2
Names
IMP (inosine 5'-monophosphate) dehydrogenase 2
IMP (inosine monophosphate) dehydrogenase 2
IMP oxireductase 2
IMPD 2
IMPDH 2
epididymis secretory sperm binding protein
inosine 5' phosphate dehydrogenase 2
inosine monophosphate dehydrogenase type II
NP_000875.2
XP_006713191.1
XP_016861838.1
XP_016861839.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012091.1 RefSeqGene

    Range
    5045..10118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000884.3NP_000875.2  inosine-5'-monophosphate dehydrogenase 2

    See identical proteins and their annotated locations for NP_000875.2

    Status: REVIEWED

    Source sequence(s)
    AC137630, BC009236, J04208
    Consensus CDS
    CCDS2786.1
    UniProtKB/Swiss-Prot
    P12268
    Related
    ENSP00000321584.4, ENST00000326739.9
    Conserved Domains (1) summary
    PTZ00314
    Location:16510
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    49024325..49029750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713128.3XP_006713191.1  inosine-5'-monophosphate dehydrogenase 2 isoform X1

    See identical proteins and their annotated locations for XP_006713191.1

    Conserved Domains (3) summary
    cd00381
    Location:99574
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
    cd04602
    Location:185300
    CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
    PTZ00314
    Location:86604
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional
  2. XM_017006350.1XP_016861839.1  inosine-5'-monophosphate dehydrogenase 2 isoform X3

    Conserved Domains (3) summary
    smart00116
    Location:229276
    CBS; Domain in cystathionine beta-synthase and other proteins
    cd00381
    Location:99525
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
    PTZ00314
    Location:86555
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional
  3. XM_017006349.1XP_016861838.1  inosine-5'-monophosphate dehydrogenase 2 isoform X2

    Conserved Domains (3) summary
    smart00116
    Location:229276
    CBS; Domain in cystathionine beta-synthase and other proteins
    cd00381
    Location:99549
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
    PTZ00314
    Location:86579
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional
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