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Impdh2 inosine monophosphate dehydrogenase 2 [ Mus musculus (house mouse) ]

Gene ID: 23918, updated on 1-Mar-2024

Summary

Official Symbol
Impdh2provided by MGI
Official Full Name
inosine monophosphate dehydrogenase 2provided by MGI
Primary source
MGI:MGI:109367
See related
Ensembl:ENSMUSG00000062867 AllianceGenome:MGI:109367
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IMPD; IMPD 2; IMPDH-II
Summary
Enables IMP dehydrogenase activity. Involved in 'de novo' XMP biosynthetic process and GMP biosynthetic process. Acts upstream of or within cellular response to interleukin-4; lymphocyte proliferation; and purine nucleotide biosynthetic process. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; heart; respiratory system; and sensory organ. Orthologous to human IMPDH2 (inosine monophosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 65.1), liver E14.5 (RPKM 58.3) and 28 other tissues See more
Orthologs
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Genomic context

See Impdh2 in Genome Data Viewer
Location:
9 F2; 9 59.5 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108437635..108442776)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108560436..108565577)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3860 Neighboring gene glutaminyl-tRNA synthetase 1 Neighboring gene glutamine-rich 1 Neighboring gene STARR-positive B cell enhancer ABC_E3861 Neighboring gene STARR-positive B cell enhancer ABC_E3862 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 3 Neighboring gene DALR anticodon binding domain containing 3 Neighboring gene microRNA 191

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables IMP dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables IMP dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables IMP dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables IMP dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
inosine-5'-monophosphate dehydrogenase 2
Names
IMP dehydrogenase 2
IMP dehydrogenase type II
inosine 5'-phosphate dehydrogenase 2
NP_001365850.1
NP_035960.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378921.1NP_001365850.1  inosine-5'-monophosphate dehydrogenase 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CT010508
    UniProtKB/TrEMBL
    Q3U9N8, Q3UPJ2
    Conserved Domains (1) summary
    PTZ00314
    Location:16534
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional
  2. NM_011830.5NP_035960.2  inosine-5'-monophosphate dehydrogenase 2 isoform 2

    See identical proteins and their annotated locations for NP_035960.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    CT010508
    Consensus CDS
    CCDS40768.1
    UniProtKB/Swiss-Prot
    P24547, Q61734, Q91Z11
    UniProtKB/TrEMBL
    Q3U9N8, Q3UAT9, Q3UPJ2
    Related
    ENSMUSP00000079888.9, ENSMUST00000081111.14
    Conserved Domains (1) summary
    PTZ00314
    Location:16510
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    108437635..108442776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)