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CXCR2 C-X-C motif chemokine receptor 2 [ Homo sapiens (human) ]

Gene ID: 3579, updated on 1-Aug-2020

Summary

Official Symbol
CXCR2provided by HGNC
Official Full Name
C-X-C motif chemokine receptor 2provided by HGNC
Primary source
HGNC:HGNC:6027
See related
Ensembl:ENSG00000180871 MIM:146928
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b
Summary
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
Expression
Biased expression in appendix (RPKM 20.0), spleen (RPKM 13.2) and 7 other tissues See more
Orthologs

Genomic context

See CXCR2 in Genome Data Viewer
Location:
2q35
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (218125294..218137253)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (218990013..219001976)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tensin 1 Neighboring gene TNS1 antisense RNA 1 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene C-X-C motif chemokine receptor 2 pseudogene 1 Neighboring gene C-X-C motif chemokine receptor 1 Neighboring gene high mobility group box 1 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef induces variable levels of CXCR2 downregulation in different cell types in an ubiquitin-independent manner PubMed
capsid gag CXCL8-induced upregulation of HIV-1 p24 levels and 2-LTR cycles is inhibited by CXCR1 or CXCR2 neutralization in HIV-1-infected monocytes-derived macrophages PubMed
matrix gag HIV-1 MA interacts with CXCR2 in primary hepatocytes PubMed
gag Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes upregulate the expression of CXCR2 receptor, which binds HIV-1 MA and its natural variant S75X, and enhances their internalization in cells PubMed
gag HIV-1 MA-induced upregulation of collagen-I and alpha-SMA expression is dependent on CXCR2 via the Rho/ROCK-1 pathway PubMed
gag Treatment of human stellate cells with HIV-1 MA upregulates the expression of CXCR2, syndecan-2, collagen-I, alpha-SMA, vimentin, and endothelin-1 PubMed
gag HIV-1 MA and SIV MA induce migration of CXCR2-expressing B cells and Jurkat cells PubMed
gag Surface plasmon resonance (SPR) binding assay demonstrates that SIV MA binds CXCR2 with higher affinity than HIV-1 MA binds CXCR2 PubMed
gag HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires activation of the Akt-dependent ERK signaling pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-X-C chemokine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-8 binding IPI
Inferred from Physical Interaction
more info
PubMed 
interleukin-8 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
acute inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cellular defense response IDA
Inferred from Direct Assay
more info
PubMed 
chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
dendritic cell chemotaxis TAS
Traceable Author Statement
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
interleukin-8-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
metanephric tubule morphogenesis IEA
Inferred from Electronic Annotation
more info
 
midbrain development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neutrophil apoptotic process IEA
Inferred from Electronic Annotation
more info
 
neutrophil activation IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
 
receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
mast cell granule IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
mitotic spindle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
C-X-C chemokine receptor type 2
Names
CXC-R2
CXCR-2
CXCR2 gene for IL8 receptor type B
GRO/MGSA receptor
IL-8 receptor type 2
IL-8R B
chemokine (CXC) receptor 2
high affinity interleukin-8 receptor B
interleukin 8 receptor type 2
interleukin 8 receptor, beta
interleukin-8 receptor type B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052975.1 RefSeqGene

    Range
    5005..16962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001168298.2NP_001161770.1  C-X-C chemokine receptor type 2

    See identical proteins and their annotated locations for NP_001161770.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124768, AJ710879, DA674925
    Consensus CDS
    CCDS2408.1
    UniProtKB/Swiss-Prot
    P25025
    UniProtKB/TrEMBL
    Q53PC4
    Conserved Domains (1) summary
    cd15178
    Location:49325
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001557.4NP_001548.1  C-X-C chemokine receptor type 2

    See identical proteins and their annotated locations for NP_001548.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124768, L19593
    Consensus CDS
    CCDS2408.1
    UniProtKB/Swiss-Prot
    P25025
    UniProtKB/TrEMBL
    Q53PC4
    Related
    ENSP00000319635.2, ENST00000318507.7
    Conserved Domains (1) summary
    cd15178
    Location:49325
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    218125294..218137253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003990.1XP_016859479.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P25025
    UniProtKB/TrEMBL
    Q53PC4
    Conserved Domains (1) summary
    cd15178
    Location:49325
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_005246530.3XP_005246587.1  C-X-C chemokine receptor type 2 isoform X1

    See identical proteins and their annotated locations for XP_005246587.1

    UniProtKB/Swiss-Prot
    P25025
    UniProtKB/TrEMBL
    Q53PC4
    Conserved Domains (1) summary
    cd15178
    Location:49325
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_017003992.1XP_016859481.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P25025
    UniProtKB/TrEMBL
    Q53PC4
    Conserved Domains (1) summary
    cd15178
    Location:49325
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_017003991.1XP_016859480.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P25025
    UniProtKB/TrEMBL
    Q53PC4
    Conserved Domains (1) summary
    cd15178
    Location:49325
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
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