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CXCR2 C-X-C motif chemokine receptor 2 [ Homo sapiens (human) ]

Gene ID: 3579, updated on 26-Jul-2021

Summary

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Official Symbol
CXCR2provided by HGNC
Official Full Name
C-X-C motif chemokine receptor 2provided by HGNC
Primary source
HGNC:HGNC:6027
See related
Ensembl:ENSG00000180871 MIM:146928
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD182; IL8R2; IL8RA; IL8RB; CMKAR2; WHIMS2; CDw128b
Summary
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
Expression
Biased expression in appendix (RPKM 20.0), spleen (RPKM 13.2) and 7 other tissues See more
Orthologs
mouse all
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Genomic context

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See CXCR2 in Genome Data Viewer
Location:
2q35
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (218125294..218137253)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (218990017..219001974)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RUN and FYVE domain containing 4 Neighboring gene C-X-C motif chemokine receptor 2 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 3825 Neighboring gene C-X-C motif chemokine receptor 1 Neighboring gene high mobility group box 1 pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inhibition of CXCR2 plays a pivotal role in re-sensitizing ovarian cancer to cisplatin treatment. Henriques TB, et al. Aging (Albany NY), 2021 May 26. PMID 34038868, Free PMC Article
  2. The Clinical Utility of Serum CXCR-2 Assessment in Colorectal Cancer (CRC) Patients. Pączek S, et al. Anticancer Res, 2021 Mar. PMID 33788733
  3. Distinguishing Sepsis From Infection by Neutrophil Dysfunction: A Promising Role of CXCR2 Surface Level. Seree-Aphinan C, et al. Front Immunol, 2020. PMID 33424860, Free PMC Article
  4. Lung adenocarcinoma-related TNF-α-dependent inflammation upregulates MHC-II on alveolar type II cells through CXCR-2 to contribute to Treg expansion. Guo N, et al. FASEB J, 2020 Sep. PMID 33000506
  5. Structural basis of CXC chemokine receptor 2 activation and signalling. Liu K, et al. Nature, 2020 Sep. PMID 32610344

See all (373) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of CXCR2 plays a pivotal role in re-sensitizing ovarian cancer to cisplatin treatment.
    Title: Inhibition of CXCR2 plays a pivotal role in re-sensitizing ovarian cancer to cisplatin treatment.
  2. Distinguishing Sepsis From Infection by Neutrophil Dysfunction: A Promising Role of CXCR2 Surface Level.
    Title: Distinguishing Sepsis From Infection by Neutrophil Dysfunction: A Promising Role of CXCR2 Surface Level.
  3. Crosstalk between head and neck cancer cells and lymphatic endothelial cells promotes tumor metastasis via CXCL5-CXCR2 signaling.
    Title: Crosstalk between head and neck cancer cells and lymphatic endothelial cells promotes tumor metastasis via CXCL5-CXCR2 signaling.
  4. Serum cytokines and CXCR2: potential tumour markers in ovarian neoplasms.
    Title: Serum cytokines and CXCR2: potential tumour markers in ovarian neoplasms.
  5. The CXCL2/IL8/CXCR2 Pathway Is Relevant for Brain Tumor Malignancy and Endothelial Cell Function.
    Title: The CXCL2/IL8/CXCR2 Pathway Is Relevant for Brain Tumor Malignancy and Endothelial Cell Function.
  6. The Clinical Utility of Serum CXCR-2 Assessment in Colorectal Cancer (CRC) Patients.
    Title: The Clinical Utility of Serum CXCR-2 Assessment in Colorectal Cancer (CRC) Patients.
  7. Lung adenocarcinoma-related TNF-alpha-dependent inflammation upregulates MHC-II on alveolar type II cells through CXCR-2 to contribute to Treg expansion.
    Title: Lung adenocarcinoma-related TNF-α-dependent inflammation upregulates MHC-II on alveolar type II cells through CXCR-2 to contribute to Treg expansion.
  8. Specific Receptors for the Chemokines CXCR2 and CXCR4 in Pancreatic Cancer.
    Title: Specific Receptors for the Chemokines CXCR2 and CXCR4 in Pancreatic Cancer.
  9. IL-8/CXCR2 Signalling Promotes Cell Proliferation in Oesophageal Squamous Cell Carcinoma and Correlates With Poor Prognosis.
    Title: IL-8/CXCR2 Signalling Promotes Cell Proliferation in Oesophageal Squamous Cell Carcinoma and Correlates With Poor Prognosis.
  10. KLF2 regulates neutrophil migration by modulating CXCR1 and CXCR2 in asthma.
    Title: KLF2 regulates neutrophil migration by modulating CXCR1 and CXCR2 in asthma.
Submit: New GeneRIF Correction See all GeneRIFs (260)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
GeneReviews: Not available
WHIM SYNDROME 2
MedGen: CN299632 OMIM: 619407 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef induces variable levels of CXCR2 downregulation in different cell types in an ubiquitin-independent manner PubMed
capsid gag CXCL8-induced upregulation of HIV-1 p24 levels and 2-LTR cycles is inhibited by CXCR1 or CXCR2 neutralization in HIV-1-infected monocytes-derived macrophages PubMed
matrix gag HIV-1 MA interacts with CXCR2 in primary hepatocytes PubMed
gag Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes upregulate the expression of CXCR2 receptor, which binds HIV-1 MA and its natural variant S75X, and enhances their internalization in cells PubMed
gag HIV-1 MA-induced upregulation of collagen-I and alpha-SMA expression is dependent on CXCR2 via the Rho/ROCK-1 pathway PubMed
gag Treatment of human stellate cells with HIV-1 MA upregulates the expression of CXCR2, syndecan-2, collagen-I, alpha-SMA, vimentin, and endothelin-1 PubMed
gag HIV-1 MA and SIV MA induce migration of CXCR2-expressing B cells and Jurkat cells PubMed
gag Surface plasmon resonance (SPR) binding assay demonstrates that SIV MA binds CXCR2 with higher affinity than HIV-1 MA binds CXCR2 PubMed
gag HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires activation of the Akt-dependent ERK signaling pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables C-X-C chemokine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables interleukin-8 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables interleukin-8 receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in acute inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular defense response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dendritic cell chemotaxis TAS
Traceable Author Statement
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in inflammatory response TAS
Traceable Author Statement
more info
 PubMed 
involved_in interleukin-8-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in metanephric tubule morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in midbrain development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neutrophil apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in neutrophil activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor internalization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in mast cell granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in secretory granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
C-X-C chemokine receptor type 2
Names
CXC-R2
CXCR-2
CXCR2 gene for IL8 receptor type B
GRO/MGSA receptor
IL-8 receptor type 2
IL-8R B
chemokine (CXC) receptor 2
high affinity interleukin-8 receptor B
interleukin 8 receptor type 2
interleukin 8 receptor, beta
interleukin-8 receptor type B

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052975.1 RefSeqGene

    Range
    5005..16962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001168298.2 → NP_001161770.1  C-X-C chemokine receptor type 2

    See identical proteins and their annotated locations for NP_001161770.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124768, AJ710879, DA674925
    Consensus CDS
    CCDS2408.1
    UniProtKB/Swiss-Prot
    P25025
    UniProtKB/TrEMBL
    Q53PC4
    Conserved Domains (1) summary
    cd15178
    Location:49 → 325
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001557.4 → NP_001548.1  C-X-C chemokine receptor type 2

    See identical proteins and their annotated locations for NP_001548.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124768, L19593
    Consensus CDS
    CCDS2408.1
    UniProtKB/Swiss-Prot
    P25025
    UniProtKB/TrEMBL
    Q53PC4
    Related
    ENSP00000319635.2, ENST00000318507.7
    Conserved Domains (1) summary
    cd15178
    Location:49 → 325
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    218125294..218137253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003990.1 → XP_016859479.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P25025
    UniProtKB/TrEMBL
    Q53PC4
    Conserved Domains (1) summary
    cd15178
    Location:49 → 325
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_005246530.3 → XP_005246587.1  C-X-C chemokine receptor type 2 isoform X1

    See identical proteins and their annotated locations for XP_005246587.1

    UniProtKB/Swiss-Prot
    P25025
    UniProtKB/TrEMBL
    Q53PC4
    Conserved Domains (1) summary
    cd15178
    Location:49 → 325
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_017003992.1 → XP_016859481.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P25025
    UniProtKB/TrEMBL
    Q53PC4
    Conserved Domains (1) summary
    cd15178
    Location:49 → 325
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_017003991.1 → XP_016859480.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P25025
    UniProtKB/TrEMBL
    Q53PC4
    Conserved Domains (1) summary
    cd15178
    Location:49 → 325
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25025.2 GenPept UniProtKB/Swiss-Prot:P25025

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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