CXCR2 C-X-C motif chemokine receptor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CXCR2provided by HGNC
Official Full Name: C-X-C motif chemokine receptor 2provided by HGNC
Primary source: HGNC:HGNC:6027
See related: Ensembl:ENSG00000180871 MIM:146928; AllianceGenome:HGNC:6027
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD182; IL8R2; IL8RA; IL8RB; CMKAR2; WHIMS2; CDw128b
Summary: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
Expression: Biased expression in appendix (RPKM 20.0), spleen (RPKM 13.2) and 7 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q35

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (218125294..218137251)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (218610987..218622946)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (218990017..219001974)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19.
Title: Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19.
CXC- receptor 2 promotes extracellular matrix production and attenuates migration in peripapillary human scleral fibroblasts under mechanical strain.
Title: CXC- receptor 2 promotes extracellular matrix production and attenuates migration in peripapillary human scleral fibroblasts under mechanical strain.
Analysis of the concentration of CXCL8 chemokine and its CXCR1 and CXCR2 receptors in peritoneal fluid of women with endometriosis.
Title: Analysis of the concentration of CXCL8 chemokine and its CXCR1 and CXCR2 receptors in peritoneal fluid of women with endometriosis.
PDCD10 promotes the aggressive behaviors of pituitary adenomas by up-regulating CXCR2 and activating downstream AKT/ERK signaling.
Title: PDCD10 promotes the aggressive behaviors of pituitary adenomas by up-regulating CXCR2 and activating downstream AKT/ERK signaling.
Analysis of CXCL8 and its receptors CXCR1/CXCR2 at the mRNA level in neoplastic tissue, as well as in serum and peritoneal fluid in patients with ovarian cance.
Title: Analysis of CXCL8 and its receptors CXCR1/CXCR2 at the mRNA level in neoplastic tissue, as well as in serum and peritoneal fluid in patients with ovarian cance.
Neutrophil Infiltration Characterized by Upregulation of S100A8, S100A9, S100A12 and CXCR2 Is Associated With the Co-Occurrence of Crohn's Disease and Peripheral Artery Disease.
Title: Neutrophil Infiltration Characterized by Upregulation of S100A8, S100A9, S100A12 and CXCR2 Is Associated With the Co-Occurrence of Crohn's Disease and Peripheral Artery Disease.
Transient post-operative overexpression of CXCR2 on monocytes of traumatic brain injury patients drives monocyte chemotaxis toward cerebrospinal fluid and enhances monocyte-mediated immunogenic cell death of neurons in vitro.
Title: Transient post-operative overexpression of CXCR2 on monocytes of traumatic brain injury patients drives monocyte chemotaxis toward cerebrospinal fluid and enhances monocyte-mediated immunogenic cell death of neurons in vitro.
Association between IL8RB C1208T mutation and risk of cancer: A pooled analysis based on 5299 cases and 6899 controls.
Title: Association between IL8RB C1208T mutation and risk of cancer: A pooled analysis based on 5299 cases and 6899 controls.
CXCR2 signaling might have a tumor-suppressive role in patients with cholangiocarcinoma.
Title: CXCR2 signaling might have a tumor-suppressive role in patients with cholangiocarcinoma.
CXCR2 Receptor: Regulation of Expression, Signal Transduction, and Involvement in Cancer.
Title: CXCR2 Receptor: Regulation of Expression, Signal Transduction, and Involvement in Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (287)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
WHIM syndrome 2 MedGen: C5543622 OMIM: 619407 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	HIV-1 Nef induces variable levels of CXCR2 downregulation in different cell types in an ubiquitin-independent manner	PubMed
capsid	gag	CXCL8-induced upregulation of HIV-1 p24 levels and 2-LTR cycles is inhibited by CXCR1 or CXCR2 neutralization in HIV-1-infected monocytes-derived macrophages	PubMed
matrix	gag	HIV-1 MA interacts with CXCR2 in primary hepatocytes	PubMed
	gag	Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes upregulate the expression of CXCR2 receptor, which binds HIV-1 MA and its natural variant S75X, and enhances their internalization in cells	PubMed
	gag	HIV-1 MA-induced upregulation of collagen-I and alpha-SMA expression is dependent on CXCR2 via the Rho/ROCK-1 pathway	PubMed
	gag	Treatment of human stellate cells with HIV-1 MA upregulates the expression of CXCR2, syndecan-2, collagen-I, alpha-SMA, vimentin, and endothelin-1	PubMed
	gag	HIV-1 MA and SIV MA induce migration of CXCR2-expressing B cells and Jurkat cells	PubMed
	gag	Surface plasmon resonance (SPR) binding assay demonstrates that SIV MA binds CXCR2 with higher affinity than HIV-1 MA binds CXCR2	PubMed
	gag	HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires activation of the Akt-dependent ERK signaling pathway	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-35278 (e-PCR)
- UniSTS:8485

STS-L19593 (e-PCR)
- UniSTS:37178

IL8RB_163 (e-PCR)
- UniSTS:277382

RH69171 (e-PCR)
- UniSTS:15270

PMC135988P2 (e-PCR)
- UniSTS:270788

RH78907 (e-PCR)
- UniSTS:35029

IL8R-1 (e-PCR)
- UniSTS:251622

PMC155779P1 (e-PCR)
- UniSTS:271352

PMC155779P2 (e-PCR)
- UniSTS:271353

PMC155779P3 (e-PCR)
- UniSTS:271354

PMC310709P2 (e-PCR)
- UniSTS:272638

Homology

Homologs of the CXCR2 gene: The CXCR2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 115 organisms have orthologs with human gene CXCR2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables C-X-C chemokine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-8 binding	IPI Inferred from Physical Interaction more info	PubMed
enables interleukin-8 receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in acute inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular defense response	IDA Inferred from Direct Assay more info	PubMed
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in dendritic cell chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in interleukin-8-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in metanephric tubule morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in midbrain development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neutrophil apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in neutrophil activation	IDA Inferred from Direct Assay more info	PubMed
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in neutrophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular permeability	IEA Inferred from Electronic Annotation more info
involved_in receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in mast cell granule	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in secretory granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: C-X-C chemokine receptor type 2

Names: CXC-R2; CXCR-2; CXCR2 gene for IL8 receptor type B; GRO/MGSA receptor; IL-8 receptor type 2; IL-8R B; chemokine (CXC) receptor 2; high affinity interleukin-8 receptor B; interleukin 8 receptor type 2; interleukin 8 receptor, beta; interleukin-8 receptor type B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052975.1 RefSeqGene

Range

5739..16962

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001168298.2 → NP_001161770.1 C-X-C chemokine receptor type 2

See identical proteins and their annotated locations for NP_001161770.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC124768, AJ710879, DA674925

Consensus CDS

CCDS2408.1

UniProtKB/Swiss-Prot

P25025, Q9P2T7

UniProtKB/TrEMBL

Q53PC4

Conserved Domains (1) summary

cd15178
Location:49 → 325

7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001557.4 → NP_001548.1 C-X-C chemokine receptor type 2

See identical proteins and their annotated locations for NP_001548.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC124768, L19593

Consensus CDS

CCDS2408.1

UniProtKB/Swiss-Prot

P25025, Q9P2T7

UniProtKB/TrEMBL

Q53PC4

Related

ENSP00000319635.2, ENST00000318507.7

Conserved Domains (1) summary

cd15178
Location:49 → 325

7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

218125294..218137251

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047444190.1 → XP_047300146.1 C-X-C chemokine receptor type 2 isoform X1

UniProtKB/Swiss-Prot

Q9P2T7

UniProtKB/TrEMBL

Q53PC4
XM_047444189.1 → XP_047300145.1 C-X-C chemokine receptor type 2 isoform X1

UniProtKB/Swiss-Prot

Q9P2T7

UniProtKB/TrEMBL

Q53PC4
XM_047444187.1 → XP_047300143.1 C-X-C chemokine receptor type 2 isoform X1

UniProtKB/Swiss-Prot

Q9P2T7

UniProtKB/TrEMBL

Q53PC4
XM_047444191.1 → XP_047300147.1 C-X-C chemokine receptor type 2 isoform X2
XM_005246530.4 → XP_005246587.1 C-X-C chemokine receptor type 2 isoform X1

See identical proteins and their annotated locations for XP_005246587.1

UniProtKB/Swiss-Prot

P25025, Q9P2T7

UniProtKB/TrEMBL

Q53PC4

Conserved Domains (1) summary

cd15178
Location:49 → 325

7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_047444188.1 → XP_047300144.1 C-X-C chemokine receptor type 2 isoform X1

UniProtKB/Swiss-Prot

Q9P2T7

UniProtKB/TrEMBL

Q53PC4
XM_017003991.2 → XP_016859480.1 C-X-C chemokine receptor type 2 isoform X1

UniProtKB/Swiss-Prot

P25025, Q9P2T7

UniProtKB/TrEMBL

Q53PC4

Conserved Domains (1) summary

cd15178
Location:49 → 325

7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors