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Cxcr2 chemokine (C-X-C motif) receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 12765, updated on 12-Sep-2021

Summary

Official Symbol
Cxcr2provided by MGI
Official Full Name
chemokine (C-X-C motif) receptor 2provided by MGI
Primary source
MGI:MGI:105303
See related
Ensembl:ENSMUSG00000026180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
I; Il; IL-; Cmka; Gpcr; CD128; IL8RA; Il8rb; CDw128; Cmkar2; Gpcr16; IL-8Rh; IL-8rb; mIL-8RH
Expression
Biased expression in placenta adult (RPKM 4.1), spleen adult (RPKM 3.8) and 8 other tissues See more
Orthologs
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Genomic context

See Cxcr2 in Genome Data Viewer
Location:
1 C3; 1 38.41 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74193153..74200405)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74153994..74161246)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (74200568..74207820)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene tensin 1 Neighboring gene VISTA enhancer mm1630 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene chemokine (C-X-C motif) receptor 1 Neighboring gene microRNA 1928

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables C-X-C chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables chemokine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chemokine receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables interleukin-8 binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-8 receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-8 receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in acute inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular defense response ISO
Inferred from Sequence Orthology
more info
 
involved_in chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in interleukin-8-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in metanephric tubule morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neutrophil apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil activation ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mast cell granule ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
C-X-C chemokine receptor type 2
Names
CXC-R2
CXCR-2
GRO/MGSA receptor
IL-8 receptor alpha chain
IL-8R B
chemokine (C-X-C) receptor 2
high affinity interleukin-8 receptor B
interleukin 8 receptor, beta
interleukin-8 receptor type B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009909.3NP_034039.1  C-X-C chemokine receptor type 2

    See identical proteins and their annotated locations for NP_034039.1

    Status: VALIDATED

    Source sequence(s)
    AC117757, CJ056061
    Consensus CDS
    CCDS15040.1
    UniProtKB/Swiss-Prot
    P35343
    Related
    ENSMUSP00000102512.3, ENSMUST00000106899.4
    Conserved Domains (1) summary
    cd15178
    Location:48324
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74193153..74200405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495638.5XP_006495701.1  C-X-C chemokine receptor type 2 isoform X1

    See identical proteins and their annotated locations for XP_006495701.1

    UniProtKB/Swiss-Prot
    P35343
    Conserved Domains (1) summary
    cd15178
    Location:48324
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
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