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Cxcr2 chemokine (C-X-C motif) receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 12765, updated on 18-Sep-2018

Summary

Official Symbol
Cxcr2provided by MGI
Official Full Name
chemokine (C-X-C motif) receptor 2provided by MGI
Primary source
MGI:MGI:105303
See related
Ensembl:ENSMUSG00000026180 Vega:OTTMUSG00000047665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD128; IL8RA; Il8rb; CDw128; Cmkar2; Gpcr16; IL-8Rh; IL-8rb; mIL-8RH
Expression
Biased expression in placenta adult (RPKM 4.1), spleen adult (RPKM 3.8) and 8 other tissues See more
Orthologs

Genomic context

See Cxcr2 in Genome Data Viewer
Location:
1 C3; 1 38.41 cM
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (74153994..74161246)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (74200568..74207820)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene tensin 1 Neighboring gene predicted gene, 31637 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene chemokine (C-X-C motif) receptor 1 Neighboring gene microRNA 1928

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-X-C chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
 
G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
chemokine receptor activity TAS
Traceable Author Statement
more info
PubMed 
interleukin-8 binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-8 receptor activity ISO
Inferred from Sequence Orthology
more info
 
interleukin-8 receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acute inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cellular defense response ISO
Inferred from Sequence Orthology
more info
 
chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemotaxis ISO
Inferred from Sequence Orthology
more info
 
chemotaxis TAS
Traceable Author Statement
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-8-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
metanephric tubule morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neutrophil apoptotic process ISO
Inferred from Sequence Orthology
more info
 
neutrophil activation ISO
Inferred from Sequence Orthology
more info
 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of leukocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
receptor internalization ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
mast cell granule ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
C-X-C chemokine receptor type 2
Names
CXC-R2
CXCR-2
GRO/MGSA receptor
IL-8 receptor alpha chain
IL-8R B
chemokine (C-X-C) receptor 2
high affinity interleukin-8 receptor B
interleukin 8 receptor, beta
interleukin-8 receptor type B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009909.3NP_034039.1  C-X-C chemokine receptor type 2

    See identical proteins and their annotated locations for NP_034039.1

    Status: VALIDATED

    Source sequence(s)
    AC117757, CJ056061
    Consensus CDS
    CCDS15040.1
    UniProtKB/Swiss-Prot
    P35343
    Related
    ENSMUSP00000102512.2, OTTMUSP00000067258, ENSMUST00000106899.3, OTTMUST00000122843
    Conserved Domains (1) summary
    pfam00001
    Location:64313
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    74153994..74161246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495638.3XP_006495701.1  C-X-C chemokine receptor type 2 isoform X1

    See identical proteins and their annotated locations for XP_006495701.1

    UniProtKB/Swiss-Prot
    P35343
    Conserved Domains (1) summary
    pfam00001
    Location:64313
    7tm_1; 7 transmembrane receptor (rhodopsin family)
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