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Cxcr2 C-X-C motif chemokine receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 12765, updated on 10-Jun-2024

Summary

Official Symbol
Cxcr2provided by MGI
Official Full Name
C-X-C motif chemokine receptor 2provided by MGI
Primary source
MGI:MGI:105303
See related
Ensembl:ENSMUSG00000026180 AllianceGenome:MGI:105303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD128; IL8RA; Il8rb; CDw128; Cmkar2; Gpcr16; IL-8Rh; IL-8rb; mIL-8RH
Summary
Enables chemokine receptor activity. Acts upstream of or within negative regulation of apoptotic process. Predicted to be located in several cellular components, including cell surface; mast cell granule; and mitotic spindle. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; epithelium; and heart. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; acute pyelonephritis; end stage renal disease; and urinary bladder cancer. Orthologous to human CXCR2 (C-X-C motif chemokine receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 4.1), spleen adult (RPKM 3.8) and 8 other tissues See more
Orthologs
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Genomic context

See Cxcr2 in Genome Data Viewer
Location:
1 C3; 1 38.41 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74193153..74200405)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74153994..74161246)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene tensin 1 Neighboring gene VISTA enhancer mm1630 Neighboring gene predicted gene, 31637 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E9467 Neighboring gene C-X-C motif chemokine receptor 1 Neighboring gene microRNA 1928

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables C-X-C chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables chemokine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chemokine receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables interleukin-8 binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-8 receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-8 receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in acute inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular defense response ISO
Inferred from Sequence Orthology
more info
 
involved_in chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in interleukin-8-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in metanephric tubule morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neutrophil apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil activation ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mast cell granule ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
C-X-C chemokine receptor type 2
Names
CXC-R2
CXCR-2
GRO/MGSA receptor
IL-8 receptor alpha chain
IL-8R B
chemokine (C-X-C motif) receptor 2
chemokine (C-X-C) receptor 2
high affinity interleukin-8 receptor B
interleukin 8 receptor, beta
interleukin-8 receptor type B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009909.3NP_034039.1  C-X-C chemokine receptor type 2

    See identical proteins and their annotated locations for NP_034039.1

    Status: VALIDATED

    Source sequence(s)
    AC117757, CJ056061
    Consensus CDS
    CCDS15040.1
    UniProtKB/Swiss-Prot
    P35343, Q53X27
    Related
    ENSMUSP00000102512.3, ENSMUST00000106899.4
    Conserved Domains (1) summary
    cd15178
    Location:48324
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74193153..74200405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495638.5XP_006495701.1  C-X-C chemokine receptor type 2 isoform X1

    See identical proteins and their annotated locations for XP_006495701.1

    UniProtKB/Swiss-Prot
    P35343, Q53X27
    Conserved Domains (1) summary
    cd15178
    Location:48324
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors