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CG12769 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35770, updated on 18-Sep-2024

Summary

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Official Symbol
CG12769provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033252
Locus tag
Dmel_CG12769
See related
AllianceGenome:FB:FBgn0033252
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG12769
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in organism. Orthologous to human IKZF2 (IKAROS family zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
44A4-44A4; 2-58 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8052080..8065554, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3939585..3953059, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43724 Neighboring gene optix Neighboring gene uncharacterized protein Neighboring gene lingerer

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in C9ORF72-ALS/FTD. Lopez-Gonzalez R, et al. Proc Natl Acad Sci U S A, 2019 May 7. PMID 31019093, Free PMC Article
  2. optix functions as a link between the retinal determination network and the dpp pathway to control morphogenetic furrow progression in Drosophila. Li Y, et al. Dev Biol, 2013 Sep 1. PMID 23792115, Free PMC Article
  3. Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover. Mastushita-Sakai T, et al. Proc Natl Acad Sci U S A, 2010 Jun 29. PMID 20547833, Free PMC Article
  4. Identification of genes that influence gurken expression. Geng C, et al. Fly (Austin), 2007 Sep-Oct. PMID 18836312
  5. A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila. Port F, et al. Elife, 2020 Feb 13. PMID 32053108, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG12769-PA
CG12769-PB
CG12769-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8052080..8065554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165585.2 → NP_724641.1  uncharacterized protein Dmel_CG12769, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724641.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z792, F3YDG2
    Related
    FBpp0087903
    Conserved Domains (3) summary
    sd00017
    Location:183 → 203
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:651 → 678
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:195 → 218
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001299252.1 → NP_001286181.1  uncharacterized protein Dmel_CG12769, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286181.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFS0, F3YDG2
    Conserved Domains (3) summary
    sd00017
    Location:183 → 203
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:662 → 689
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:195 → 218
    zf-H2C2_2; Zinc-finger double domain

  3. NM_136503.3 → NP_610347.3  uncharacterized protein Dmel_CG12769, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610347.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z791, Q8SZH3
    Related
    FBpp0087904
    Conserved Domains (3) summary
    sd00017
    Location:187 → 207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:655 → 682
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:199 → 222
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LFS0 A0A0B4LFS0
A1Z791 A1Z791
A1Z792 A1Z792
Q8SZH3 Q8SZH3

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