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IL2RB interleukin 2 receptor subunit beta [ Homo sapiens (human) ]

Gene ID: 3560, updated on 27-Jun-2020

Summary

Official Symbol
IL2RBprovided by HGNC
Official Full Name
interleukin 2 receptor subunit betaprovided by HGNC
Primary source
HGNC:HGNC:6009
See related
Ensembl:ENSG00000100385 MIM:146710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD122; IMD63; IL15RB; P70-75
Summary
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. [provided by RefSeq, Sep 2016]
Expression
Broad expression in spleen (RPKM 33.2), lymph node (RPKM 19.6) and 14 other tissues See more
Orthologs

Genomic context

See IL2RB in Genome Data Viewer
Location:
22q12.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (37125838..37175118, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (37521878..37552414, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 214 Neighboring gene potassium channel tetramerization domain containing 17 Neighboring gene transmembrane serine protease 6 Neighboring gene IL2RB promoter Neighboring gene IL2RB LTR promoter Neighboring gene C1q and TNF related 6 Neighboring gene somatostatin receptor 3 Neighboring gene ribosomal protein L39 pseudogene 41

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
IMMUNODEFICIENCY 63 WITH LYMPHOPROLIFERATION AND AUTOIMMUNITY
MedGen: C5193126 OMIM: 618495 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
A large-scale, consortium-based genomewide association study of asthma.
NHGRI GWA Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
NHGRI GWA Catalog
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
NHGRI GWA Catalog
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of interleukin 2 receptor, beta (IL2RB) in human B cells PubMed
env The inhibition of IL-2R expression and proliferation induced by the interaction of CD4 with HIV-1 envelope glycoprotein gp120 is correlated with the inhibition of expression and activation of Janus kinase JAK3 PubMed
env HIV-1 gp120 exerts a dose-dependent reduction of IL-2 mRNA expression, IL-2 production, and surface IL-2 receptor expression in CD4+ lymphocytes PubMed
Pr55(Gag) gag MVA-gag induces a significant release of cytokines such as IL-2R, IL-6, IL-8, TNF-alpha, IFN-gamma, MCP-1, MIP-1alpha, MIP-1beta, and RANTES by the infected monocyte-derived dendritic cells in comparison with uninfected cells PubMed
Tat tat HIV-1 Tat downregulates IL-2R in Jurkat and H9 T-cell lines, an effect that may contribute to the immunosuppressive effects of HIV-1 Tat PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-15 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-2 binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-2 binding ISS
Inferred from Sequence or Structural Similarity
more info
 
interleukin-2 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-2 receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to interleukin-2 receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-15-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-15-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-2-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-2-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endosome TAS
Traceable Author Statement
more info
 
external side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
interleukin-2 receptor complex TAS
Traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-2 receptor subunit beta
Names
CD122 antigen
IL-2 receptor subunit beta
IL-2R subunit beta
IL-2RB
high affinity IL-2 receptor beta subunit
high affinity IL-2 receptor subunit beta
interleukin 15 receptor, beta
interleukin 2 receptor, beta
interleukin-15 receptor subunit beta
p75

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000878.5NP_000869.1  interleukin-2 receptor subunit beta precursor

    See identical proteins and their annotated locations for NP_000869.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AA834613, AK312860, AL022314
    Consensus CDS
    CCDS13942.1
    UniProtKB/Swiss-Prot
    P14784
    Related
    ENSP00000216223.5, ENST00000216223.10
    Conserved Domains (2) summary
    smart00060
    Location:134216
    FN3; Fibronectin type 3 domain
    cl26386
    Location:386531
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  2. NM_001346222.1NP_001333151.1  interleukin-2 receptor subunit beta precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, compared to variant 1. This variant represents use of an upstream long terminal repeat (LTR) promoter and exon sequence, and results in placental-specific expression. Variants 1, 2 and 3 encode the same protein. (PMID: 21865161)
    Source sequence(s)
    AA834613, AL022314, Z82188
    Consensus CDS
    CCDS13942.1
    UniProtKB/Swiss-Prot
    P14784
    Conserved Domains (2) summary
    smart00060
    Location:134216
    FN3; Fibronectin type 3 domain
    cl26386
    Location:386531
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  3. NM_001346223.2NP_001333152.1  interleukin-2 receptor subunit beta precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, compared to variant 1. This variant represents use of an upstream long terminal repeat (LTR) promoter and exon sequence, and results in placental-specific expression. Variants 1, 2 and 3 encode the same protein. (PMID: 21865161)
    Source sequence(s)
    AL022314, Z82188
    Consensus CDS
    CCDS13942.1
    UniProtKB/Swiss-Prot
    P14784
    Conserved Domains (2) summary
    smart00060
    Location:134216
    FN3; Fibronectin type 3 domain
    cl26386
    Location:386531
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    37125838..37175118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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