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CCN1 cellular communication network factor 1 [ Homo sapiens (human) ]

Gene ID: 3491, updated on 18-Jun-2019

Summary

Official Symbol
CCN1provided by HGNC
Official Full Name
cellular communication network factor 1provided by HGNC
Primary source
HGNC:HGNC:2654
See related
Ensembl:ENSG00000142871 MIM:602369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIG1; CYR61; IGFBP10
Summary
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
Expression
Broad expression in gall bladder (RPKM 285.2), spleen (RPKM 216.9) and 20 other tissues See more
Orthologs

Genomic context

See CCN1 in Genome Data Viewer
Location:
1p22.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (85580761..85583950)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (86046444..86049650)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC646626 Neighboring gene BCL10 immune signaling adaptor Neighboring gene dimethylarginine dimethylaminohydrolase 1 Neighboring gene uncharacterized LOC107985054 Neighboring gene uncharacterized LOC107985057 Neighboring gene uncharacterized LOC112268231 Neighboring gene zinc finger HIT-type containing 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular matrix binding IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
apoptotic process involved in heart morphogenesis IEA
Inferred from Electronic Annotation
more info
 
atrial septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
atrioventricular valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
chondroblast differentiation IEA
Inferred from Electronic Annotation
more info
 
chorio-allantoic fusion IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
intussusceptive angiogenesis IEA
Inferred from Electronic Annotation
more info
 
labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of bone mineralization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cartilage development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ceramide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of osteoblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phospholipase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
ventricular septum development IEA
Inferred from Electronic Annotation
more info
 
wound healing, spreading of cells IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
CCN family member 1
Names
IBP-10
IGF-binding protein 10
IGFBP-10
cysteine rich angiogenic inducer 61
cysteine-rich heparin-binding protein 61
cysteine-rich, anigogenic inducer, 61
insulin-like growth factor-binding protein 10
protein CYR61

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001554.5NP_001545.2  CCN family member 1 precursor

    See identical proteins and their annotated locations for NP_001545.2

    Status: REVIEWED

    Source sequence(s)
    BC009199, BP387218, DA764894
    Consensus CDS
    CCDS706.1
    UniProtKB/Swiss-Prot
    O00622
    UniProtKB/TrEMBL
    Q6FI18
    Related
    ENSP00000398736.2, ENST00000451137.7
    Conserved Domains (4) summary
    smart00209
    Location:232272
    TSP1; Thrombospondin type 1 repeats
    smart00214
    Location:100159
    VWC; von Willebrand factor (vWF) type C domain
    pfam00219
    Location:2678
    IGFBP; Insulin-like growth factor binding protein
    cl21545
    Location:293375
    GHB_like; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    85580761..85583950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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