CCN1 cellular communication network factor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CCN1provided by HGNC
Official Full Name: cellular communication network factor 1provided by HGNC
Primary source: HGNC:HGNC:2654
See related: Ensembl:ENSG00000142871 MIM:602369; AllianceGenome:HGNC:2654
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GIG1; CYR61; IBP-10; IGFBP10; IGFBP-10
Summary: The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
Expression: Broad expression in gall bladder (RPKM 285.2), spleen (RPKM 216.9) and 20 other tissues See more
Orthologs: all
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Genomic context

Location:: 1p22.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (85580761..85583950)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (85421570..85424759)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (86046444..86049633)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CYR61 Acts as an Intracellular Microtubule-Associated Protein and Coordinates Mitotic Progression via PLK1-FBW7 Pathway.
Title: CYR61 Acts as an Intracellular Microtubule-Associated Protein and Coordinates Mitotic Progression via PLK1-FBW7 Pathway.
Cellular communication network factor 1 promotes retinal leakage in diabetic retinopathy via inducing neutrophil stasis and neutrophil extracellular traps extrusion.
Title: Cellular communication network factor 1 promotes retinal leakage in diabetic retinopathy via inducing neutrophil stasis and neutrophil extracellular traps extrusion.
CYR61 confers chemoresistance by upregulating survivin expression in triple-negative breast cancer.
Title: CYR61 confers chemoresistance by upregulating survivin expression in triple-negative breast cancer.
Nanomechanics of CCN1-Mediated Staphylococcus aureus Phagocytosis.
Title: Nanomechanics of CCN1-Mediated Staphylococcus aureus Phagocytosis.
Upregulation of CYR61 by TGF-beta and YAP signaling exerts a counter-suppression of hepatocellular carcinoma.
Title: Upregulation of CYR61 by TGF-β and YAP signaling exerts a counter-suppression of hepatocellular carcinoma.
Global Proteomics Analysis of Lysophosphatidic Acid Signaling in PC-3 Human Prostate Cancer Cells: Role of CCN1.
Title: Global Proteomics Analysis of Lysophosphatidic Acid Signaling in PC-3 Human Prostate Cancer Cells: Role of CCN1.
Changes and related factors of blood CCN1 levels in diabetic patients.
Title: Changes and related factors of blood CCN1 levels in diabetic patients.
CircUSP48 promotes malignant behavior by regulating CYR61 via miR-365 in osteosarcoma.
Title: CircUSP48 promotes malignant behavior by regulating CYR61 via miR-365 in osteosarcoma.
CCN1 expression is regulated by mechanical stimuli in tendons.
Title: CCN1 expression is regulated by mechanical stimuli in tendons.
[Effect of Cyr61 on Imatinib Resistance in Chronic Myeloid Leukemia and Its Mechanism].
Title: [Effect of Cyr61 on Imatinib Resistance in Chronic Myeloid Leukemia and Its Mechanism].

Submit: New GeneRIF Correction See all GeneRIFs (273)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables extracellular matrix binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of bone mineralization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of developmental process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ossification	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of osteoblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of multicellular organismal development	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular matrix	HDA more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in non-collagenous component of interstitial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in non-collagenous component of interstitial matrix	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CCN family member 1

Names: IGF-binding protein 10; cysteine rich angiogenic inducer 61; cysteine-rich heparin-binding protein 61; cysteine-rich, anigogenic inducer, 61; insulin-like growth factor-binding protein 10; protein CYR61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001554.5 → NP_001545.2 CCN family member 1 precursor

See identical proteins and their annotated locations for NP_001545.2

Status: REVIEWED

Source sequence(s)

BC009199, BP387218, DA764894

Consensus CDS

CCDS706.1

UniProtKB/Swiss-Prot

O00622, O14934, O43775, Q9BZL7

UniProtKB/TrEMBL

A0ACI8QFB6, D3DT19, Q6FI18

Related

ENSP00000398736.2, ENST00000451137.7

Conserved Domains (4) summary

smart00209
Location:232 → 272

TSP1; Thrombospondin type 1 repeats

smart00214
Location:100 → 159

VWC; von Willebrand factor (vWF) type C domain

pfam00219
Location:26 → 78

IGFBP; Insulin-like growth factor binding protein

cl21545
Location:293 → 375

GHB_like; Glycoprotein hormone beta chain homologues