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Cyr61 cysteine rich protein 61 [ Mus musculus (house mouse) ]

Gene ID: 16007, updated on 2-Sep-2018

Summary

Official Symbol
Cyr61provided by MGI
Official Full Name
cysteine rich protein 61provided by MGI
Primary source
MGI:MGI:88613
See related
Ensembl:ENSMUSG00000028195 Vega:OTTMUSG00000055191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CCN1; Igfbp10; AI325051
Expression
Broad expression in lung adult (RPKM 41.5), limb E14.5 (RPKM 37.8) and 26 other tissues See more
Orthologs

Genomic context

See Cyr61 in Genome Data Viewer
Location:
3 H2; 3 70.18 cM
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (145646971..145649985, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (145309935..145312949, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene zinc finger, HIT type 6 Neighboring gene predicted gene, 40164 Neighboring gene dimethylarginine dimethylaminohydrolase 1 Neighboring gene ribosomal protein L36A, pseudogene 2 Neighboring gene predicted gene, 35187 Neighboring gene B cell leukemia/lymphoma 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
extracellular matrix binding IDA
Inferred from Direct Assay
more info
PubMed 
growth factor binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
apoptotic process involved in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
atrial septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
atrioventricular valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion ISO
Inferred from Sequence Orthology
more info
 
cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
chemotaxis ISO
Inferred from Sequence Orthology
more info
 
chondroblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
chorio-allantoic fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular matrix organization IDA
Inferred from Direct Assay
more info
PubMed 
intussusceptive angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
labyrinthine layer blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ceramide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
ventricular septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing, spreading of cells ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
extracellular matrix HDA PubMed 
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space HDA PubMed 

General protein information

Preferred Names
protein CYR61
Names
3CH61
CCN family member 1
IBP-10
IGF-binding protein 10
IGFBP-10
cysteine-rich angiogenic inducer 61
insulin-like growth factor-binding protein 10
intermediate early

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010516.2NP_034646.1  protein CYR61 precursor

    See identical proteins and their annotated locations for NP_034646.1

    Status: VALIDATED

    Source sequence(s)
    AC136729, AK159452
    Consensus CDS
    CCDS17895.1
    UniProtKB/Swiss-Prot
    P18406
    UniProtKB/TrEMBL
    Q3TX21
    Related
    ENSMUSP00000029846.3, OTTMUSP00000072117, ENSMUST00000029846.4, OTTMUST00000136695
    Conserved Domains (4) summary
    pfam00007
    Location:291373
    Cys_knot; Cystine-knot domain
    smart00209
    Location:230270
    TSP1; Thrombospondin type 1 repeats
    smart00214
    Location:100159
    VWC; von Willebrand factor (vWF) type C domain
    pfam00219
    Location:2678
    IGFBP; Insulin-like growth factor binding protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    145646971..145649985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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