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IGFBP6 insulin like growth factor binding protein 6 [ Homo sapiens (human) ]

Gene ID: 3489, updated on 3-Jan-2019

Summary

Official Symbol
IGFBP6provided by HGNC
Official Full Name
insulin like growth factor binding protein 6provided by HGNC
Primary source
HGNC:HGNC:5475
See related
Ensembl:ENSG00000167779 MIM:146735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IBP6
Expression
Broad expression in fat (RPKM 60.7), prostate (RPKM 49.9) and 17 other tissues See more
Orthologs

Genomic context

See IGFBP6 in Genome Data Viewer
Location:
12q13.13
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (53097652..53102344)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53491436..53496128)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene tensin 2 Neighboring gene microRNA 6757 Neighboring gene SPRY domain containing 3 Neighboring gene sterol O-acyltransferase 2 Neighboring gene vesicle transport through interaction with t-SNAREs 1B pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection downregulates IGFBP6 expression in CEM*174 cells and mixed PBMC from HIV infected patients PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fibronectin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor I binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor II binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
regulation of insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor binary complex IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
insulin-like growth factor-binding protein 6
Names
IBP-6
IGF binding protein 6
IGFBP-6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002178.3NP_002169.1  insulin-like growth factor-binding protein 6 precursor

    See identical proteins and their annotated locations for NP_002169.1

    Status: VALIDATED

    Source sequence(s)
    BQ925731, M69054
    Consensus CDS
    CCDS8846.1
    UniProtKB/Swiss-Prot
    P24592
    Related
    ENSP00000301464.3, ENST00000301464.3
    Conserved Domains (2) summary
    smart00121
    Location:27105
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:163234
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    53097652..53102344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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