Igfbp6 insulin-like growth factor binding protein 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Igfbp6provided by MGI
Official Full Name: insulin-like growth factor binding protein 6provided by MGI
Primary source: MGI:MGI:96441
See related: Ensembl:ENSMUSG00000023046 AllianceGenome:MGI:96441
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IGFBP-6
Summary: Predicted to enable fibronectin binding activity; identical protein binding activity; and insulin-like growth factor binding activity. Predicted to be involved in cell migration; positive regulation of stress-activated MAPK cascade; and regulation of insulin-like growth factor receptor signaling pathway. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including blastocyst; compacted morula; genitourinary system; liver; and spleen. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP6 (insulin like growth factor binding protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 124.7), ovary adult (RPKM 109.7) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15; 15 F2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (102052621..102057947)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (102144186..102149512)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genome-wide methylation analysis showed that two genes with hypomethylated promoters, Igfbp6 and Foxs1, are upregulated in GDX-induced adrenocortical neoplasms.
Title: Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret.
Report multiple post-translational modifications of mouse insulin-like growth factor binding protein-6 expressed in epithelial Madin-Darby canine kidney cells.
Title: Multiple post-translational modifications of mouse insulin-like growth factor binding protein-6 expressed in epithelial Madin-Darby canine kidney cells.
Igfbp-6 is a target of sonic hedgehog signaling in the urogenital sinus
Title: Sonic hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 during fetal prostate development.
These results reveal a novel function for MMP-9 and -12 in developmental myelination likely through regulating IGF-1 bioavailability.
Title: Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)

General gene information

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Markers

Igfbp6 (e-PCR), detects polymorphism
- UniSTS:471317

NoName (e-PCR)
- UniSTS:548459

Igfbp6 (e-PCR), detects polymorphism
- UniSTS:143491

RH131180 (e-PCR)
- UniSTS:214463

BF404305 (e-PCR)
- UniSTS:247030

Homology

Homologs of the Igfbp6 gene: The Igfbp6 gene is conserved in human, chimpanzee, dog, cow, and rat.
Orthologs from Annotation Pipeline: 350 organisms have orthologs with human gene Igfbp6
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables fibronectin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor I binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables insulin-like growth factor I binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor II binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables insulin-like growth factor II binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of insulin-like growth factor binary complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: insulin-like growth factor-binding protein 6

Names: IBP-6; IGF-binding protein 6; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 6 PRECURSOR (IGFBP-6) (IBP-6) (IGF-BINDING PROTEIN 6)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008344.3 → NP_032370.2 insulin-like growth factor-binding protein 6 precursor

See identical proteins and their annotated locations for NP_032370.2

Status: VALIDATED

Source sequence(s)

AK157982, AW123368, BQ828082

Consensus CDS

CCDS27871.1

UniProtKB/Swiss-Prot

P47880, Q91X24

Related

ENSMUSP00000023807.7, ENSMUST00000023807.7

Conserved Domains (2) summary

smart00121
Location:28 → 106

IB; Insulin growth factor-binding protein homologues

pfam00086
Location:160 → 232

Thyroglobulin_1; Thyroglobulin type-1 repeat