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IGFBP1 insulin like growth factor binding protein 1 [ Homo sapiens (human) ]

Gene ID: 3484, updated on 17-Jun-2018
Official Symbol
IGFBP1provided by HGNC
Official Full Name
insulin like growth factor binding protein 1provided by HGNC
Primary source
HGNC:HGNC:5469
See related
Ensembl:ENSG00000146678 MIM:146730; Vega:OTTHUMG00000152343
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1
Summary
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017]
Expression
Biased expression in liver (RPKM 308.2), placenta (RPKM 135.7) and 1 other tissue See more
Orthologs
See IGFBP1 in Genome Data Viewer
Location:
7p12.3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (45888419..45893668)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (45927959..45933267)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene septin 14 pseudogene 7 Neighboring gene RNA, U6 small nuclear 326, pseudogene Neighboring gene insulin like growth factor binding protein 3 Neighboring gene uncharacterized LOC102723446 Neighboring gene RNA, U7 small nuclear 76 pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
NHGRI GWA Catalog
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
HIV-1 infected clinical samples have plasma extracellular vesicles that contain elevated CCL1 (I309), IGFBP1, CCL5 (RANTES), GMCSF, ANG, ADIPOQ (ACRP30), CSF3 (GCSF), CXCL1 (GRO), ICAM1, IL2RA, IL6R, TNFRSF1A, and TIMP1 when compared to healthy donors PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of insulin-like growth factor binding protein 1 (IGFBP1) in primary human brain microvascular endothelial cells PubMed
Vpu vpu The gene expression of insulin-like growth factor binding protein 1 (IGFBP1) increases in cells infected with vpu-deficient HIV-1 compared to cells infected with the wild-type virus, indicating that HIV-1 Vpu downregulates IGFBP1 protein expression PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
insulin-like growth factor I binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor I binding IDA
Inferred from Direct Assay
more info
PubMed 
insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor II binding IDA
Inferred from Direct Assay
more info
PubMed 
insulin-like growth factor binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
PERK-mediated unfolded protein response TAS
Traceable Author Statement
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
regulation of insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
insulin-like growth factor-binding protein 1
Names
IBP-1
IGF-binding protein 1
IGFBP-1
alpha-pregnancy-associated endometrial globulin
amniotic fluid binding protein
binding protein-25
binding protein-26
binding protein-28
growth hormone independent-binding protein
placental protein 12

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000596.3NP_000587.1  insulin-like growth factor-binding protein 1 precursor

    See identical proteins and their annotated locations for NP_000587.1

    Status: REVIEWED

    Source sequence(s)
    BX336957, CA429917, M31145
    Consensus CDS
    CCDS5504.1
    UniProtKB/Swiss-Prot
    P08833
    Related
    ENSP00000275525.3, OTTHUMP00000159561, ENST00000275525.7
    Conserved Domains (2) summary
    smart00121
    Location:28105
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:176251
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    45888419..45893668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013029.1: Suppressed sequence

    Description
    NM_001013029.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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