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IFNG interferon gamma [ Homo sapiens (human) ]

Gene ID: 3458, updated on 1-Jun-2020

Summary

Official Symbol
IFNGprovided by HGNC
Official Full Name
interferon gammaprovided by HGNC
Primary source
HGNC:HGNC:5438
See related
Ensembl:ENSG00000111537 MIM:147570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IFG; IFI
Summary
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
Expression
Biased expression in bone marrow (RPKM 3.6), lymph node (RPKM 3.2) and 8 other tissues See more
Orthologs

Genomic context

See IFNG in Genome Data Viewer
Location:
12q15
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (68154768..68159740, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (68548550..68553521, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984526 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 70 Neighboring gene 39S ribosomal protein L21, mitochondrial pseudogene Neighboring gene uncharacterized LOC105369818 Neighboring gene interleukin 26 Neighboring gene interleukin 22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Aplastic anemia
MedGen: C0002874 OMIM: 609135 GeneReviews: Not available
Compare labs
Hepatitis c virus, susceptibility to
MedGen: C1835407 OMIM: 609532 GeneReviews: Not available
Compare labs
Human immunodeficiency virus type 1, susceptibility to
MedGen: C1836230 OMIM: 609423 GeneReviews: Not available
Compare labs
Mycobacterium tuberculosis, susceptibility to
MedGen: C1834752 OMIM: 607948 GeneReviews: Not available
Compare labs
Tuberous sclerosis 2
MedGen: C1860707 OMIM: 613254 GeneReviews: Tuberous Sclerosis Complex
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
NHGRI GWA Catalog
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV/tuberculosis coinfection upregulates IFNG expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with only tuberculosis) PubMed

Protein interactions

Protein Gene Interaction Pubs
Asp asp A pool of ASP-overlapping peptides enhance IFN-gamma responses of T cells in HIV-1 seropositive patients PubMed
asp Antisense reading frame-derived cryptic epitopes from the env gene induce upregulation of IFNG immune-response on the surface of CD8+ T-cells PubMed
Envelope surface glycoprotein gp120 env Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta PubMed
env Treatment of cells with HIV-1 gp120 induces the release of IFN gamma PubMed
env HIV-1 Env gp120 peptides can stimulate cytoplasmic IFN-gamma response in CD8+ T cells in the presence of dendritic cells PubMed
env HIV-1 gp120-induced IL-23 upregulated SOCS1 protein in T cells, which inhibits IFN-gamma production and killing of CEF-pulsed monocytes PubMed
env HIV-1 gp120-treated myeloid dendritic cell (mDC) downregulates IL-2 and IFN-gamma production compared to LPS-treated mDC PubMed
env Frequent IFN-gamma and TNF-alpha NK cell responses to HIV-1 gp120 are dominant during chronic HIV-1 infection PubMed
env HIV-1 gp120-expanded CD33+ myeloid derived suppressor cells inhibits IFN-gamma release from autologous T cells PubMed
env IL-11 inhibits HIV-1 gp120-mediated downregulation of IFN-gamma in human NK cells PubMed
env NK cells that respond with IFN-gamma and TNF-alpha cytokine production to HIV-1 gp120 peptides have reduced CD16 and NKp46 expression and have increased levels of CD57 PubMed
env Gp120/IFN-gamma-mediated cytotoxicity of human brain micro vascular endothelial cells (HBMECs) involves the p38 MAPK signaling pathway PubMed
env Peptides of gp120 representing binding regions for CD4 and chemokine receptors, as well as CD4 antibody, inhibit gp120/IFN-gamma-mediated cytotoxicity of human brain micro vascular endothelial cells (HBMECs) PubMed
env HIV-1 gp120 in the presence of IFN-gamma induces cytotoxicity of human brain micro vascular endothelial cells (HBMECs) derived from children but not from adults PubMed
env Interferon-alpha- and interferon-gamma-induced sialoadhesin-expressing monocytes adsorb HIV-1 through interaction with the sialic acid residues on the viral envelope glycoprotein gp120 PubMed
env In the presence of HIV-1 gp120, stimulation through the CD28 pathway partially restores IL-2 and IFN-gamma production by T cell lines in response to anti-CD3 antibodies PubMed
env HIV-1 gp120 inhibits natural killer (NK) cell natural cytotoxicity and this inhibition also affects the production of the proinflammatory cytokine interferon-gamma (IFN-gamma); the inhibitory activity of gp120 can be prevented by coincubation with VIP PubMed
env Induction of the receptor activator of cytokine nuclear factor kappa B ligand (RANKL) is mediated by HIV-1 gp120; the gp120-mediated induction of RANKL is blocked by interferon-gamma PubMed
env Secretion of IL-12 is found in macrophages primed with gamma interferon (IFN-gamma) and subsequently treated with gp120 PubMed
env Secretion of IL-2 and IFN-gamma stimulated with anti-CD3 antibodies is inhibited by HIV-1 gp120 in T cell lines PubMed
env Sulfate containing galactolipids such as sulfatides on responder cells may be part of the HIV-1 gp120-membrane complex that initiates the induction of interferon (IFN) PubMed
env HIV-1 gp41 or gp120 synthetic peptides induce the production of interleukin (IL)-1 and tumor necrosis factor (TNF); in contrast, gp41 or gp120 synthetic peptides are able to depress the production of interferon (IFN)-alpha, IFN-gamma, and IL-2 PubMed
env IFN-gamma and gp120-induced activation of Na+/H+ exchange appears to be mediated through activation of tyrosine kinase (TK), because TK inhibitors block the action of IFN-gamma and gp120 PubMed
env Treatment of human colonic epithelial cells with recombinant gamma-interferon (rlFN gamma) induces a dose-dependent inhibition of Galactosyl ceramide (GalCer) expression on the cell surface; GalCer is a receptor for HIV-1 gp120 PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 Env induces release of IFN-gamma from CAR-transduced T cells PubMed
env Pretreatment of CD4+ cells with HIV-1 gp160 significantly reduces PHA-induced secretion of IFN-gamma and IL-2 but augments IL-4 production PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 inhibits activation of PBMCs and upregulates the expression of IFN-gamma in peptide-treated PBMCs PubMed
env PWM, LPS, IFN-gamma and IL-6 can increase HIV-1 gp41 binding to human B cells PubMed
env IFN-gamma production in mononuclear leukocytes from an HIV-1-seropositive man is induced by different concentrations of a recombinant HIV-1 envelope glycoprotein gp41 and gp120 fragment PubMed
Nef nef HIV-1 Nef-stimulated CD8+ T cells upregulate mRNAs expression for IFN-gamma, MIP-1alpha, MIP-1alphaP, MIP-1beta, TNFRSF9, XCL1, and GM-CSF compared to unstimulated cells PubMed
nef The proportion of HIV-1 Nef-specific CD8+ T cells endowed with TNF-alpha+, IFN-gamma+, CD107A+, and MIP-1beta+ is significantly higher in patients with the lowest virus set point than those with the highest virus set point PubMed
nef Coincubation of HIV-1 Nef and IFN-gamma downregulates COX-2 expression compared to untreated, Nef- or IFN-gamma-treated Caco-2 cells PubMed
nef HIV-1 Nef inhibits IFN-gamma-induced apoptosis and upregulates TNF-alpha, IL-6 and MIP-3alpha production by Caco-2 cells while downregulating IL-10 production PubMed
nef Exogenous Nef taken up by Caco-2 cells increases intestinal epithelial permeability, inhibits the IFN-gamma-induced reduction of transepitelial resistance and decreases the tight junction proteins occludin and ZO1 expression PubMed
nef HIV-1 Nef has super antigen properties in that it binds to MHC class II antigens and activates T cells, causing T cell proliferation and production of the T helper 1 cytokines IL-2 and IFN-gamma PubMed
nef Upon T cell activation, HIV-1 Nef expression downregulates both IL-2 and IFN-gamma production in a dose-dependent manner PubMed
nef PBMC proliferation induced by exogenous HIV-1 Nef is associated with upregulation of interferon-gamma (IFN-gamma) PubMed
Pr55(Gag) gag Treatment of PBMCs taken from treatment-naive HIV chronically infected individuals with a HIV-1 Gag peptide pool in the presence of ADAM10 inhibitor upregulates the levels of Tim-3 and IFN-gamma in CD8+ T cells PubMed
gag HIV-1-exposed monocyte-derived dendritic cells induce weak secretion of IFN-gamma and low amounts of intracellular Gag expression in the presence of SAMHD1 PubMed
gag HIV-1 Gag peptides can stimulate cytoplasmic IFN-gamma response in CD8 T cells PubMed
gag MVA-gag induces a significant release of cytokines such as IL-2R, IL-6, IL-8, TNF-alpha, IFN-gamma, MCP-1, MIP-1alpha, MIP-1beta, and RANTES by the infected monocyte-derived dendritic cells in comparison with uninfected cells PubMed
gag The proportion of HIV-1 Gag-specific CD8+ T cells endowed with TNF-alpha+, IFN-gamma+, CD107A+, and MIP-1beta+ is significantly higher in patients with the lowest virus set point than those with the highest virus set point PubMed
gag IFN-gamma-stimulated expression of APOL1 in differentiated U937 monocytes contributes to inhibition of HIV-1 Gag/p24 expression PubMed
gag Gag-specific interferon (IFN)-gamma secreting responses correlate with the rate of disease progression as defined by the annual rate of CD4 decline in patients PubMed
gag HIV-1 Gag virus-like particles expressed by recombinant baculoviruses activate human PBMC to release IFN-gamma in a dose and time dependent manner PubMed
gag HIV-1 Gag virus-like particle-induced human monocyte-derived dendritic cell maturation activates autologous NK cells, leading to their proliferation, and production of interferon-gamma PubMed
gag HIV-1 Gag p24-specific CD4+ T cells producing IL-2 and IFN-gamma are increased post vaccination PubMed
gag Interferon-gamma can counteract the inhibitory effect of peptides based on the Capsid protein of HIV-1 Gag on antibody response to Sheep Red Cell Antigen PubMed
gag The Capsid (p24) protein of HIV-1 Gag inhibits interferon gamma induced increases in HLA-DR and cytochrome B heavy chain mRNA levels in the human monocyte-like cell line THP1 PubMed
gag The Matrix protein of HIV-1 Gag enhances the cytokine-induced production of interferon gamma PubMed
gag The Matrix protein of HIV-1 Gag and interferon gamma are structurally similar and have been found to bind in vitro PubMed
Tat tat HIV-1 Tat upregulates the production of cytokines, including TNF-alpha, IL-6, IL-10, IL-12, IFN-alpha1, and IFN-gamma, in human monocyte derived-dendritic cells and in primary human Muller glia PubMed
tat HIV-1 Tat-induced inhibition of IFN-gamma release is regulated by the interaction of Tat-RGD domain with alpha5beta1 and alpha5beta3 integrins in CD8+ T cells PubMed
tat The contact between peptide-stimulated CD8+ T-lymphocytes and immobilized HIV-1 Tat inhibits the release of IFN-gamma PubMed
tat HIV-1 Tat upregulates IL-2 and IFN-gamma production in stimulated CD8+ T cells PubMed
tat JAK/STAT pathway plays a major role in Tat/IFN-gamma-mediated CXCL10 induction in macrophages PubMed
tat The synergistic upregulation of CXCL10 expression by HIV-1 Tat and IFN-gamma is inhibited by mu-opioid receptor (MOR) antagonist beta-funaltrexamine in human astrocytes PubMed
tat HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells PubMed
tat Tat and IFN-gamma synergistically induce the expression of CXCL10, which is inhibited by MEK1/2 inhibitor and the p38 mitogen-activated protein kinase (MAPK) inhibitor PubMed
tat HIV-1 Tat increases CXCL10 expression in IFN-gamma and TNF-alpha stimulated human astrocytes via NADPH oxidase PubMed
tat HIV-1 Tat suppresses IFN-gamma-induced LC3B protein expression and autophagosome formation through Tat-mediated suppression of STAT1 phosphorylation PubMed
tat Pretreatment of THP-1 cells with HIV-1 Tat/T-bet co-cultures with CD4+T cells, resulting in increased levels of IFN-gamma PubMed
tat HIV-1 Tat impairs the IFNgamma-receptor signaling pathway, in primary human monocytes, at the level of STAT1 activation via Tat-dependent induction of suppressor of cytokine signaling-2 (SOCS-2) activity PubMed
tat HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha PubMed
tat HIV-1 Tat acts as a co-stimulatory molecule that affects viral replication by modulating host immune response through induction of T-bet expression and IFN-gamma secretion PubMed
tat HIV-1 Tat interacts with IFN-gamma, which upregulates the Tat receptor VEGFR2/KDR, to produce cytotoxicity in human brain micro vascular endothelial cells PubMed
tat HIV-1 Tat upregulates IFN-gamma expression by uninfected mononuclear cells PubMed
tat HIV-1 Tat inhibits IFN-gamma release by NK cells upon contact with dendritic cells PubMed
tat HIV-1 Tat delivered by CyaA from Bordetella pertussis induces a Th1-polarized immune response and HIV-Tat-specific gamma interferon-producing CD8(+) T cells are generated after vaccination with CyaA-E5-Tat in a CD4(+) T-cell-independent manner PubMed
tat HIV-1 Tat synergizes with IFN-gamma to induce iNOS activity in purified rat microglial cultures PubMed
tat IFN-gamma interacts with HIV-1 Tat to induce endothelial cells to proliferate and invade the extracellular matrix by upregulating the receptors for Tat (integrins alpha-5-beta-1 and alpha-v-beta-3), suggesting Tat and IFN-gamma play major roles in AIDS-KS PubMed
tat IFN-gamma inhibits the transactivation of the HIV-1 LTR promoter by HIV-1 Tat PubMed
tat HIV-1 Tat inhibits IFN-gamma induced iNOS activity in a murine macrophage cell line PubMed
tat IL-1beta, TNF-alpha, and IFN-gamma synergize with HIV-1 Tat to promote in nude mice the development of angioproliferative Kaposi's sarcoma-like lesions PubMed
tat HIV-1 Tat enhances translation of the interferon-inducible enzymes 2-5A synthetase and dsRNA-dependent protein kinase, suggesting interaction of Tat with interferons during HIV-1 replication PubMed
Vif vif HIV-1 Vif downregulates the expression of interferon-gamma (IFNG) in Vif-expression T cells PubMed
Vpr vpr Exogenous Vpr compromises subsequent pDC/NK interplay through inhibition of IFN-gamma production by NK cells PubMed
vpr HIV-1 Vpr inhibits interferon gamma secretion in infected T cells PubMed
vpr HIV-1 Vpr impairs NK cell function through cytokine dysregulation, including diminshed expression of CD107a, reduced production of IFN-gamma, differential regulation of IL-12 and TGF-beta, and activation of the Smad3 signalling pathway PubMed
vpr Expression of HIV-1 Vpr in U937 cells upregulates gamma interferon expression PubMed
capsid gag Peptides derived from HIV-1 p24 induces release of IFN-gamma in monocyte-derived DCs and macrophages PubMed
gag PLA-p24- or p24-loaded human monocyte-derived dendritic cells enhance HIV-1-specific T-cell response by increased levels of IFN-gamma and IL-2 in comparison with PLA-loaded cells alone PubMed
gag HIV-1 CA-stimulated CD8+ T cells upregulate mRNAs expression for IFN-gamma, MIP-1alpha, MIP-1alphaP, MIP-1beta, TNFRSF9, XCL1, and GM-CSF compared to unstimulated cells PubMed
gag IFN-gamma-stimulated expression of APOL1 in differentiated U937 monocytes contributes to inhibition of HIV-1 Gag/p24 expression PubMed
gag IFN-gamma and/or IL-2 responses characterized by secreting cells contribute more to the HIV-1 CA specific response in acute infection early disease (AIED) than in chronically infected individuals PubMed
gag Pretreating dendritic cells with INF-gamma overcomes the HIV-1 CA-mediated decreased levels of presentation of ovalbumin to a SIINFEKL-specific CD8(+) T-cell hybridoma PubMed
gag HIV-1 Capsid (p24) inhibits interferon gamma induced increases in HLA-DR and cytochrome B heavy chain mRNA levels in the human monocyte-like cell line THP1 PubMed
gag Interferon-gamma can counteract the inhibitory effect of HIV-1 Capsid based peptides on antibody response to Sheep Red Cell Antigen PubMed
matrix gag HIV-1 Matrix enhances the cytokine-induced production of interferon gamma PubMed
gag HIV-1 Matrix and interferon gamma are structurally similar and have been found to bind in vitro PubMed
reverse transcriptase gag-pol Up-regulation of LMP7 by IFN-gamma enhances proteasomal degradation of HIV-1 RT and presentation of the VIYQYMDDL epitope derived from HIV-1 RT PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interferon-gamma receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
JAK-STAT cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
astrocyte activation IDA
Inferred from Direct Assay
more info
PubMed 
astrocyte activation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
humoral immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interferon-gamma-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
macrophage activation involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
macrophage differentiation IDA
Inferred from Direct Assay
more info
PubMed 
microglial cell activation IGI
Inferred from Genetic Interaction
more info
PubMed 
microglial cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of amyloid-beta clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-17 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tau-protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
neuroinflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MHC class II biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of NMDA glutamate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of amyloid-beta formation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of amyloid-beta formation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of calcidiol 1-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cellular respiration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of chemokine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of core promoter binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokine secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of exosomal secretion HDA PubMed 
positive regulation of ferrous iron import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fructose 1,6-bisphosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression HDA PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-1 beta biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-23 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of killing of cells of other organism IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neurogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of neuron death IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of nitric-oxide synthase biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of nitrogen compound metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation of STAT protein NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein localization to plasma membrane HDA PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of receptor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of smooth muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of tumor necrosis factor secretion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vitamin D biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
regulation of protein ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of regulatory T cell differentiation TAS
Traceable Author Statement
more info
 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interferon gamma
Names
IFN-gamma
immune interferon

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015840.1 RefSeqGene

    Range
    5002..9974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000619.3NP_000610.2  interferon gamma precursor

    See identical proteins and their annotated locations for NP_000610.2

    Status: REVIEWED

    Source sequence(s)
    AC007458, BC070256, V00543
    Consensus CDS
    CCDS8980.1
    UniProtKB/Swiss-Prot
    P01579
    Related
    ENSP00000229135.3, ENST00000229135.4
    Conserved Domains (1) summary
    pfam00714
    Location:15152
    IFN-gamma; Interferon gamma

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    68154768..68159740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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