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ZNF879 zinc finger protein 879 [ Homo sapiens (human) ]

Gene ID: 345462, updated on 13-Mar-2020

Summary

Official Symbol
ZNF879provided by HGNC
Official Full Name
zinc finger protein 879provided by HGNC
Primary source
HGNC:HGNC:37273
See related
Ensembl:ENSG00000234284
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DKFZp686E2433
Summary
This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and thirteen C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and induce heterochromatin formation. [provided by RefSeq, Jul 2017]
Expression
Broad expression in testis (RPKM 2.9), thyroid (RPKM 1.6) and 24 other tissues See more
Orthologs

Genomic context

See ZNF879 in Genome Data Viewer
Location:
5q35.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (179023759..179035064)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (178450776..178461388)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene F-box and WD repeat domain containing 2 pseudogene Neighboring gene glutamate metabotropic receptor 6 Neighboring gene zinc finger protein 354C Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 2 Neighboring gene Sharpr-MPRA regulatory region 9172

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136116.3NP_001129588.1  zinc finger protein 879

    See identical proteins and their annotated locations for NP_001129588.1

    Status: REVIEWED

    Source sequence(s)
    AC104117, AK300504, BM971752, BX114675, BX648737, DC350553
    Consensus CDS
    CCDS47352.1
    UniProtKB/Swiss-Prot
    B4DU55
    Related
    ENSP00000414887.2, ENST00000444149.7
    Conserved Domains (3) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
    COG5048
    Location:202558
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486506
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001353372.2NP_001340301.1  zinc finger protein 879

    Status: REVIEWED

    Source sequence(s)
    AC104117, BM971752
    Consensus CDS
    CCDS47352.1
    Conserved Domains (3) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
    COG5048
    Location:202558
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486506
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001353373.2NP_001340302.1  zinc finger protein 879

    Status: REVIEWED

    Source sequence(s)
    AC104117, BM971752
    Consensus CDS
    CCDS47352.1
    Conserved Domains (3) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
    COG5048
    Location:202558
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486506
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001353374.2NP_001340303.1  zinc finger protein 879

    Status: REVIEWED

    Source sequence(s)
    AC104117, BM971752
    Consensus CDS
    CCDS47352.1
    Conserved Domains (3) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
    COG5048
    Location:202558
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486506
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    179023759..179035064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534551.2XP_011532853.1  zinc finger protein 879 isoform X1

    See identical proteins and their annotated locations for XP_011532853.1

    UniProtKB/Swiss-Prot
    B4DU55
    Conserved Domains (3) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
    COG5048
    Location:202558
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486506
    ZF_C2H2; C2H2 Zn finger [structural motif]
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