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ZNF860 zinc finger protein 860 [ Homo sapiens (human) ]

Gene ID: 344787, updated on 5-Mar-2024

Summary

Official Symbol
ZNF860provided by HGNC
Official Full Name
zinc finger protein 860provided by HGNC
Primary source
HGNC:HGNC:34513
See related
Ensembl:ENSG00000197385 AllianceGenome:HGNC:34513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lymph node (RPKM 1.1), prostate (RPKM 0.9) and 21 other tissues See more
Orthologs
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Genomic context

Location:
3p23-p22.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (31981750..32006443)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (31984716..32009928)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (32023242..32033215)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein like 10 Neighboring gene OSBPL10 antisense RNA 1 Neighboring gene zinc finger protein 587 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:31938297-31938798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:31987818-31988420 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:31988421-31989022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14164 Neighboring gene small nucleolar RNA SNORA25 Neighboring gene ribosomal protein L21 pseudogene 40

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • FLJ60236

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137674.3NP_001131146.2  zinc finger protein 860

    See identical proteins and their annotated locations for NP_001131146.2

    Status: VALIDATED

    Source sequence(s)
    AC108485, AK294003, BQ268755
    Consensus CDS
    CCDS46784.1
    UniProtKB/Swiss-Prot
    A6NHJ4, B4DFA4
    Related
    ENSP00000373274.3, ENST00000360311.5
    Conserved Domains (5) summary
    smart00349
    Location:2464
    KRAB; krueppel associated box
    COG5048
    Location:284617
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:288308
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2463
    KRAB; KRAB box
    pfam13465
    Location:328353
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    31981750..32006443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448072.1XP_047304028.1  zinc finger protein 860 isoform X1

    UniProtKB/Swiss-Prot
    A6NHJ4, B4DFA4
  2. XM_047448074.1XP_047304030.1  zinc finger protein 860 isoform X1

    UniProtKB/Swiss-Prot
    A6NHJ4, B4DFA4
  3. XM_047448073.1XP_047304029.1  zinc finger protein 860 isoform X1

    UniProtKB/Swiss-Prot
    A6NHJ4, B4DFA4

RNA

  1. XR_001740138.2 RNA Sequence

  2. XR_007095674.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    31984716..32009928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346427.1XP_054202402.1  zinc finger protein 860 isoform X1

    UniProtKB/Swiss-Prot
    A6NHJ4, B4DFA4
  2. XM_054346429.1XP_054202404.1  zinc finger protein 860 isoform X1

    UniProtKB/Swiss-Prot
    A6NHJ4, B4DFA4
  3. XM_054346428.1XP_054202403.1  zinc finger protein 860 isoform X1

    UniProtKB/Swiss-Prot
    A6NHJ4, B4DFA4

RNA

  1. XR_007073404.1 RNA Sequence

  2. XR_007073405.1 RNA Sequence