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IFIT2 interferon induced protein with tetratricopeptide repeats 2 [ Homo sapiens (human) ]

Gene ID: 3433, updated on 7-Jun-2020

Summary

Official Symbol
IFIT2provided by HGNC
Official Full Name
interferon induced protein with tetratricopeptide repeats 2provided by HGNC
Primary source
HGNC:HGNC:5409
See related
Ensembl:ENSG00000119922 MIM:147040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P54; G10P2; IFI54; ISG54; cig42; IFI-54; IFIT-2; GARG-39; IFI-54K; ISG-54K; ISG-54 K
Expression
Broad expression in bone marrow (RPKM 19.8), spleen (RPKM 15.9) and 24 other tissues See more
Orthologs

Genomic context

See IFIT2 in Genome Data Viewer
Location:
10q23.31
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (89302046..89309271)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (91061706..91069033)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene lipase A, lysosomal acid type Neighboring gene uncharacterized LOC105378419 Neighboring gene uncharacterized LOC101926887 Neighboring gene interferon induced protein with tetratricopeptide repeats 3 Neighboring gene interferon induced protein with tetratricopeptide repeats 6, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 and the viral protein Tat modulate the expression of interferon-induced protein with tetratricopeptide repeats 2 (IFIT2; IFI54) in immature dendritic cells and monocyte-derived macrophages PubMed
Vpr vpr HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells PubMed
vpr HIV-1 Vpr upregulates the gene expression of IFIT1 in human monocyte-derived dendritic cells PubMed
Vpu vpu The expression of IFIT2 is enhanced in Vpu-deficient HIV-1-infected cells as compared to that in wild-type-infected cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic mitochondrial changes TAS
Traceable Author Statement
more info
PubMed 
cellular response to interferon-alpha IEA
Inferred from Electronic Annotation
more info
 
defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interferon-induced protein with tetratricopeptide repeats 2
Names
Interferon, alpha-inducible protein (MW 54kD)
interferon-induced 54 kDa protein
interferon-induced protein 54

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001547.5NP_001538.4  interferon-induced protein with tetratricopeptide repeats 2

    See identical proteins and their annotated locations for NP_001538.4

    Status: VALIDATED

    Source sequence(s)
    AA143609, AA765174, AL353751, BC005987, EB387611
    Consensus CDS
    CCDS41548.1
    UniProtKB/Swiss-Prot
    P09913
    UniProtKB/TrEMBL
    Q05DN2
    Related
    ENSP00000360891.3, ENST00000371826.4
    Conserved Domains (2) summary
    sd00006
    Location:248275
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:51112
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    89302046..89309271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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