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Ifit2 interferon-induced protein with tetratricopeptide repeats 2 [ Mus musculus (house mouse) ]

Gene ID: 15958, updated on 12-May-2024

Summary

Official Symbol
Ifit2provided by MGI
Official Full Name
interferon-induced protein with tetratricopeptide repeats 2provided by MGI
Primary source
MGI:MGI:99449
See related
Ensembl:ENSMUSG00000045932 AllianceGenome:MGI:99449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P54; Ifi54; GARG-39; IFI-54K
Summary
Predicted to enable RNA binding activity. Involved in response to virus. Acts upstream of or within cellular response to interferon-alpha. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Orthologous to human IFIT2 (interferon induced protein with tetratricopeptide repeats 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E18 (RPKM 2.6), bladder adult (RPKM 2.3) and 22 other tissues See more
Orthologs
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Genomic context

See Ifit2 in Genome Data Viewer
Location:
19 C1; 19 29.73 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34527961..34553934)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34550550..34576534)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr19:34575305-34575606 Neighboring gene lysosomal acid lipase A Neighboring gene STARR-seq mESC enhancer starr_45997 Neighboring gene STARR-positive B cell enhancer ABC_E5697 Neighboring gene STARR-positive B cell enhancer ABC_E4275 Neighboring gene predicted gene, 31417 Neighboring gene STARR-positive B cell enhancer ABC_E11027 Neighboring gene STARR-positive B cell enhancer ABC_E11028 Neighboring gene interferon-induced protein with tetratricopeptide repeats 3 Neighboring gene interferon induced protein with tetratricpeptide repeats 1B like 1 Neighboring gene STARR-positive B cell enhancer ABC_E5698 Neighboring gene interferon-induced protein with tetratricopeptide repeats 3B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interferon-induced protein with tetratricopeptide repeats 2
Names
IFIT-2
glucocorticoid-attenuated response gene 39 protein
interferon-induced 54 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355262.1NP_001342191.1  interferon-induced protein with tetratricopeptide repeats 2

    Status: VALIDATED

    Source sequence(s)
    AC102249
    Consensus CDS
    CCDS29761.1
    UniProtKB/Swiss-Prot
    Q62385, Q64112
    UniProtKB/TrEMBL
    Q6GTM0
    Conserved Domains (2) summary
    TIGR02917
    Location:145359
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:242270
    TPR; TPR repeat [structural motif]
  2. NM_008332.3NP_032358.1  interferon-induced protein with tetratricopeptide repeats 2

    See identical proteins and their annotated locations for NP_032358.1

    Status: VALIDATED

    Source sequence(s)
    BC050835, BF730115, CJ044173, U43085
    Consensus CDS
    CCDS29761.1
    UniProtKB/Swiss-Prot
    Q62385, Q64112
    UniProtKB/TrEMBL
    Q6GTM0
    Related
    ENSMUSP00000099890.4, ENSMUST00000102826.4
    Conserved Domains (2) summary
    TIGR02917
    Location:145359
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:242270
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    34527961..34553934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161447.1XP_036017340.1  interferon-induced protein with tetratricopeptide repeats 2 isoform X1

    UniProtKB/Swiss-Prot
    Q62385, Q64112
    UniProtKB/TrEMBL
    Q6GTM0
    Conserved Domains (2) summary
    TIGR02917
    Location:145359
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:242270
    TPR; TPR repeat [structural motif]
  2. XM_006526705.4XP_006526768.1  interferon-induced protein with tetratricopeptide repeats 2 isoform X1

    See identical proteins and their annotated locations for XP_006526768.1

    UniProtKB/Swiss-Prot
    Q62385, Q64112
    UniProtKB/TrEMBL
    Q6GTM0
    Conserved Domains (2) summary
    TIGR02917
    Location:145359
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:242270
    TPR; TPR repeat [structural motif]