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IDH2 isocitrate dehydrogenase (NADP(+)) 2 [ Homo sapiens (human) ]

Gene ID: 3418, updated on 3-May-2020

Summary

Official Symbol
IDH2provided by HGNC
Official Full Name
isocitrate dehydrogenase (NADP(+)) 2provided by HGNC
Primary source
HGNC:HGNC:5383
See related
Ensembl:ENSG00000182054 MIM:147650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IDH; IDP; IDHM; IDPM; ICD-M; D2HGA2; mNADP-IDH
Summary
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in heart (RPKM 100.1), kidney (RPKM 92.8) and 24 other tissues See more
Orthologs

Genomic context

See IDH2 in Genome Data Viewer
Location:
15q26.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (90083045..90102468, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90626283..90645730, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 710 Neighboring gene Sharpr-MPRA regulatory region 12348 Neighboring gene ZNF710 antisense RNA 1 Neighboring gene IDH2 divergent transcript Neighboring gene RNA, 7SL, cytoplasmic 346, pseudogene Neighboring gene semaphorin 4B Neighboring gene ribosomal protein S12 pseudogene 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of isocitrate dehydrogenase 2 (IDH2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD binding IEA
Inferred from Electronic Annotation
more info
 
isocitrate dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
isocitrate dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
isocitrate dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
2-oxoglutarate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
NADP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
NADP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
carbohydrate metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
glyoxylate cycle IEA
Inferred from Electronic Annotation
more info
 
isocitrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
isocitrate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of glial cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of matrix metallopeptidase secretion IEA
Inferred from Electronic Annotation
more info
 
tricarboxylic acid cycle TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
peroxisome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
isocitrate dehydrogenase [NADP], mitochondrial
Names
NADP(+)-specific ICDH
isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
isocitrate dehydrogenase 2 (NADP+), mitochondrial
oxalosuccinate decarboxylase
NP_001276839.1
NP_001277043.1
NP_002159.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023302.1 RefSeqGene

    Range
    4923..23499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_611

mRNA and Protein(s)

  1. NM_001289910.1NP_001276839.1  isocitrate dehydrogenase [NADP], mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001276839.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK294148, BC009244
    Consensus CDS
    CCDS76792.1
    UniProtKB/Swiss-Prot
    P48735
    Related
    ENSP00000446147.2, ENST00000540499.2
    Conserved Domains (1) summary
    PTZ00435
    Location:1399
    PTZ00435; isocitrate dehydrogenase; Provisional
  2. NM_001290114.2NP_001277043.1  isocitrate dehydrogenase [NADP], mitochondrial isoform 3

    See identical proteins and their annotated locations for NP_001277043.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC087284, AK299987, X69433
    UniProtKB/Swiss-Prot
    P48735
    UniProtKB/TrEMBL
    B4DSZ6
    Conserved Domains (1) summary
    cl00445
    Location:1321
    Iso_dh; Isocitrate/isopropylmalate dehydrogenase
  3. NM_002168.4NP_002159.2  isocitrate dehydrogenase [NADP], mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_002159.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC087284, AK312627, X69433
    Consensus CDS
    CCDS10359.1
    UniProtKB/Swiss-Prot
    P48735
    Related
    ENSP00000331897.3, ENST00000330062.7
    Conserved Domains (1) summary
    PTZ00435
    Location:39451
    PTZ00435; isocitrate dehydrogenase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    90083045..90102468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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