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Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 269951, updated on 22-Feb-2024

Summary

Official Symbol
Idh2provided by MGI
Official Full Name
isocitrate dehydrogenase 2 (NADP+), mitochondrialprovided by MGI
Primary source
MGI:MGI:96414
See related
Ensembl:ENSMUSG00000030541 AllianceGenome:MGI:96414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IDPm; Idh-2; E430004F23
Summary
Enables isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in several processes, including NADP biosynthetic process; isocitrate metabolic process; and negative regulation of matrix metallopeptidase secretion. Predicted to act upstream of or within glyoxylate cycle and tricarboxylic acid cycle. Located in cytosol and peroxisome. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; carcinoma (multiple); and lung cancer (multiple). Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 329.1), kidney adult (RPKM 134.6) and 22 other tissues See more
Orthologs
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Genomic context

See Idh2 in Genome Data Viewer
Location:
7 D2; 7 45.43 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79744594..79768356, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80094845..80118608, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19293 Neighboring gene predicted gene, 31966 Neighboring gene STARR-seq mESC enhancer starr_19295 Neighboring gene STARR-seq mESC enhancer starr_19296 Neighboring gene STARR-positive B cell enhancer ABC_E4939 Neighboring gene STARR-positive B cell enhancer ABC_E8970 Neighboring gene STARR-seq mESC enhancer starr_19297 Neighboring gene STARR-positive B cell enhancer ABC_E6561 Neighboring gene STARR-positive B cell enhancer ABC_E6562 Neighboring gene zinc finger protein 710 Neighboring gene STARR-positive B cell enhancer ABC_E6563 Neighboring gene predicted gene, 21057 Neighboring gene STARR-seq mESC enhancer starr_19312 Neighboring gene predicted gene, 53380 Neighboring gene STARR-positive B cell enhancer ABC_E3729 Neighboring gene STARR-positive B cell enhancer ABC_E6564 Neighboring gene predicted gene 45202 Neighboring gene STARR-positive B cell enhancer ABC_E8182 Neighboring gene STARR-seq mESC enhancer starr_19316 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87337544-87337745 Neighboring gene STARR-seq mESC enhancer starr_19318 Neighboring gene STARR-seq mESC enhancer starr_19319 Neighboring gene STARR-seq mESC enhancer starr_19320 Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B Neighboring gene STARR-seq mESC enhancer starr_19323

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables isocitrate dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables isocitrate dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables isocitrate dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in NADP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in NADP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within glyoxylate cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in isocitrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of glial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of matrix metallopeptidase secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
isocitrate dehydrogenase [NADP], mitochondrial
Names
ICD-M
IDH
IDP
NADP(+)-specific ICDH
NADP+-specific isocitrate dehydrogenase
oxalosuccinate decarboxylase
NP_766599.2
XP_006540974.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173011.2NP_766599.2  isocitrate dehydrogenase [NADP], mitochondrial precursor

    See identical proteins and their annotated locations for NP_766599.2

    Status: VALIDATED

    Source sequence(s)
    AK169395, BQ747924, BY311397
    Consensus CDS
    CCDS39994.1
    UniProtKB/Swiss-Prot
    P54071, Q8C2R9, Q9EQK1
    Related
    ENSMUSP00000103007.4, ENSMUST00000107384.10
    Conserved Domains (1) summary
    PTZ00435
    Location:39451
    PTZ00435; isocitrate dehydrogenase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    79744594..79768356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540911.4XP_006540974.1  isocitrate dehydrogenase [NADP], mitochondrial isoform X1

    Conserved Domains (1) summary
    cl00445
    Location:39323
    Iso_dh; Isocitrate/isopropylmalate dehydrogenase

RNA

  1. XR_003946485.2 RNA Sequence