Format

Send to:

Choose Destination

NANOS1 nanos C2HC-type zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 340719, updated on 11-Jun-2021

Summary

Official Symbol
NANOS1provided by HGNC
Official Full Name
nanos C2HC-type zinc finger 1provided by HGNC
Primary source
HGNC:HGNC:23044
See related
Ensembl:ENSG00000188613 MIM:608226
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOS1; NOS-1; SPGF12; EC_Rep1a; ZC2HC12A
Summary
This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NANOS1 in Genome Data Viewer
Location:
10q26.11
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (119029714..119033730)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (120789226..120793242)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene 36 Neighboring gene lactate dehydrogenase A pseudogene 5 Neighboring gene eukaryotic translation initiation factor 3 subunit A Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene Sharpr-MPRA regulatory region 2008

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation repressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050764.1 RefSeqGene

    Range
    4999..9015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_199461.4NP_955631.1  nanos homolog 1

    See identical proteins and their annotated locations for NP_955631.1

    Status: REVIEWED

    Source sequence(s)
    AF458985, AL157788
    Consensus CDS
    CCDS7607.1
    UniProtKB/Swiss-Prot
    Q8WY41
    Related
    ENSP00000393275.1, ENST00000425699.3
    Conserved Domains (1) summary
    pfam05741
    Location:214266
    zf-nanos; Nanos RNA binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    119029714..119033730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001009553.1: Suppressed sequence

    Description
    NM_001009553.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
Support Center