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Nanos1 nanos C2HC-type zinc finger 1 [ Mus musculus (house mouse) ]

Gene ID: 332397, updated on 15-Apr-2019

Summary

Official Symbol
Nanos1provided by MGI
Official Full Name
nanos C2HC-type zinc finger 1provided by MGI
Primary source
MGI:MGI:2669254
See related
Ensembl:ENSMUSG00000072437
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NOS-1
Summary
This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2and may be involved in regulating translation as a post-transcriptional repressor. Mutations in a similar protein in human are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]
Orthologs

Genomic context

See Nanos1 in Genome Data Viewer
Location:
19; 19 D3
Exon count:
1
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (60755987..60759914)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (60831890..60835817)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41883 Neighboring gene predicted gene, 46652 Neighboring gene predicted gene, 34459 Neighboring gene predicted gene, 34406 Neighboring gene microRNA 3084-2 Neighboring gene eukaryotic translation initiation factor 3, subunit A Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene family with sequence similarity 45, member A

Genomic regions, transcripts, and products

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell migration ISO
Inferred from Sequence Orthology
more info
 
cerebellar neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
 
posttranscriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
posttranscriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cell growth IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
tissue homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nanos homolog 1
Names
nanos 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178421.3NP_848508.2  nanos homolog 1

    See identical proteins and their annotated locations for NP_848508.2

    Status: REVIEWED

    Source sequence(s)
    BC056473, BC085512
    Consensus CDS
    CCDS29941.1
    UniProtKB/Swiss-Prot
    Q80WY3
    Related
    ENSMUSP00000096874.2, ENSMUST00000088237.5
    Conserved Domains (1) summary
    pfam05741
    Location:189241
    zf-nanos; Nanos RNA binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

    Range
    60755987..60759914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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