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FAM221A family with sequence similarity 221 member A [ Homo sapiens (human) ]

Gene ID: 340277, updated on 5-Sep-2021

Summary

Official Symbol
FAM221Aprovided by HGNC
Official Full Name
family with sequence similarity 221 member Aprovided by HGNC
Primary source
HGNC:HGNC:27977
See related
Ensembl:ENSG00000188732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C7orf46
Expression
Broad expression in testis (RPKM 6.7), stomach (RPKM 4.2) and 25 other tissues See more
Orthologs
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Genomic context

See FAM221A in Genome Data Viewer
Location:
7p15.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (23680118..23703249)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (23719818..23742269)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375187 Neighboring gene coiled-coil domain containing 126 Neighboring gene FCF1 pseudogene 1 Neighboring gene serine/threonine kinase 31 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 pseudogene 3 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45875, MGC72075, DKFZp686F0810

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
protein FAM221A
Names
uncharacterized protein C7orf46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127364.3NP_001120836.1  protein FAM221A isoform 2

    See identical proteins and their annotated locations for NP_001120836.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    BC026000, BC042034, DB538373
    Consensus CDS
    CCDS47561.1
    UniProtKB/Swiss-Prot
    A4D161
    UniProtKB/TrEMBL
    A0A024RA57
    Related
    ENSP00000386927.3, ENST00000409192.7
    Conserved Domains (1) summary
    pfam14753
    Location:20212
    DUF4475; Domain of unknown function (DUF4475)
  2. NM_001127365.3NP_001120837.1  protein FAM221A isoform 3

    See identical proteins and their annotated locations for NP_001120837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    BC026000, BC042034, DB538373, HY056255
    Consensus CDS
    CCDS47562.1
    UniProtKB/Swiss-Prot
    A4D161
    Related
    ENSP00000386631.3, ENST00000409994.3
    Conserved Domains (1) summary
    pfam14753
    Location:22154
    DUF4475; Domain of unknown function (DUF4475)
  3. NM_001300932.2NP_001287861.1  protein FAM221A isoform 4

    See identical proteins and their annotated locations for NP_001287861.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.
    Source sequence(s)
    AI370799, BC042034, BC063130, BU958830, HY056255
    Consensus CDS
    CCDS75570.1
    UniProtKB/Swiss-Prot
    A4D161
    UniProtKB/TrEMBL
    B8ZZQ8
    Related
    ENSP00000386900.1, ENST00000409653.5
    Conserved Domains (1) summary
    pfam14753
    Location:22156
    DUF4475; Domain of unknown function (DUF4475)
  4. NM_199136.5NP_954587.2  protein FAM221A isoform 1

    See identical proteins and their annotated locations for NP_954587.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI370799, BC042034, BC063130, HY056255
    Consensus CDS
    CCDS5385.1
    UniProtKB/Swiss-Prot
    A4D161
    Related
    ENSP00000342576.4, ENST00000344962.9
    Conserved Domains (1) summary
    pfam14753
    Location:20214
    DUF4475; Domain of unknown function (DUF4475)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    23680118..23703249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515369.2XP_011513671.1  protein FAM221A isoform X1

    See identical proteins and their annotated locations for XP_011513671.1

    UniProtKB/Swiss-Prot
    A4D161
    Conserved Domains (1) summary
    pfam14753
    Location:20214
    DUF4475; Domain of unknown function (DUF4475)
  2. XM_017012134.1XP_016867623.1  protein FAM221A isoform X3

    UniProtKB/TrEMBL
    A0A024RA57
    Conserved Domains (1) summary
    pfam14753
    Location:20212
    DUF4475; Domain of unknown function (DUF4475)
  3. XM_011515370.2XP_011513672.1  protein FAM221A isoform X2

    Conserved Domains (1) summary
    pfam14753
    Location:20214
    DUF4475; Domain of unknown function (DUF4475)
  4. XM_011515371.2XP_011513673.1  protein FAM221A isoform X4

    See identical proteins and their annotated locations for XP_011513673.1

    Conserved Domains (1) summary
    pfam14753
    Location:20213
    DUF4475; Domain of unknown function (DUF4475)
  5. XM_011515372.2XP_011513674.1  protein FAM221A isoform X5

    Conserved Domains (1) summary
    pfam14753
    Location:1151
    DUF4475; Domain of unknown function (DUF4475)
  6. XM_017012135.1XP_016867624.1  protein FAM221A isoform X6

RNA

  1. XR_001744690.2 RNA Sequence

  2. XR_002956432.1 RNA Sequence

  3. XR_428081.3 RNA Sequence

  4. XR_002956430.1 RNA Sequence

  5. XR_001744692.1 RNA Sequence

  6. XR_001744691.1 RNA Sequence

  7. XR_001744693.1 RNA Sequence

  8. XR_002956431.1 RNA Sequence

  9. XR_001744694.1 RNA Sequence

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