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ZNF546 zinc finger protein 546 [ Homo sapiens (human) ]

Gene ID: 339327, updated on 5-Aug-2022

Summary

Official Symbol
ZNF546provided by HGNC
Official Full Name
zinc finger protein 546provided by HGNC
Primary source
HGNC:HGNC:28671
See related
Ensembl:ENSG00000187187 AllianceGenome:HGNC:28671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF49
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be integral component of membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 3.3), thyroid (RPKM 0.9) and 22 other tissues See more
Orthologs
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Genomic context

See ZNF546 in Genome Data Viewer
Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39997060..40021038)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42817266..42841244)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40502967..40526945)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904720 Neighboring gene proteasome 26S subunit, ATPase 4 Neighboring gene Sharpr-MPRA regulatory region 7932 Neighboring gene PAT1 homolog 1, processing body mRNA decay factor pseudogene Neighboring gene zinc finger protein 780B

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC43537

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 546
Names
CTC-471F3.6
zinc finger protein 49

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297763.2NP_001284692.1  zinc finger protein 546 isoform 2

    See identical proteins and their annotated locations for NP_001284692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC007842, AF087985, AK122968, AK292528, DA217689
    Consensus CDS
    CCDS77297.1
    UniProtKB/Swiss-Prot
    Q86UE3
    UniProtKB/TrEMBL
    B3KVL3, M0QY24
    Related
    ENSP00000469540.1, ENST00000600094.5
    Conserved Domains (5) summary
    smart00349
    Location:3494
    KRAB; krueppel associated box
    COG5048
    Location:357797
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:557577
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3473
    KRAB; KRAB box
    pfam13465
    Location:625650
    zf-H2C2_2; Zinc-finger double domain
  2. NM_178544.5NP_848639.2  zinc finger protein 546 isoform 1

    See identical proteins and their annotated locations for NP_848639.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007842, AF087985, AK122968, AK292528, DA217689
    Consensus CDS
    CCDS12548.1
    UniProtKB/Swiss-Prot
    A8K913, Q86UE3
    UniProtKB/TrEMBL
    B3KVL3
    Related
    ENSP00000339823.3, ENST00000347077.9
    Conserved Domains (5) summary
    smart00349
    Location:60120
    KRAB; krueppel associated box
    COG5048
    Location:383823
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:583603
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6099
    KRAB; KRAB box
    pfam13465
    Location:651676
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    39997060..40021038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646206.1 Reference GRCh38.p14 PATCHES

    Range
    272203..296181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    42817266..42841244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)